Code examples: curl
PREFIX sbd: <https://www.sbd4nano.eu/rdf/#>
PREFIX sbdbel: <https://www.sbd4nano.eu/bel/#>
PREFIX dc: <http://purl.org/dc/elements/1.1/>
PREFIX dcterms: <http://purl.org/dc/terms/>
PREFIX sio: <http://semanticscience.org/resource/SIO_>
PREFIX sbdbel2: <https://h2020-sbd4nano.github.io/sbdbel/>
SELECT DISTINCT ?cause ?type ?outcome ?material ?evidence
WHERE {
VALUES ?ca { sbdbel:CausalAssertion sbd:CausalAssertion sbdbel2:CausalAssertion }
?relation a ?ca ; sbdbel:relationship ?type .
OPTIONAL { ?relation sbdbel:cause / rdfs:label ?cause . }
OPTIONAL { ?relation sbdbel:outcome / rdfs:label ?outcome . }
OPTIONAL { ?relation sbdbel:NP | sio:000332 | sbdbel2:NP / rdfs:label ?material . }
OPTIONAL { ?relation sbdbel:evidence ?evidence . }
} ORDER BY DESC(?relation)
| cause | type | outcome | material | evidence |
| Alterations, Cellular proliferation / hyperplasia | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Formation, Hepatocellular and Bile duct tumors | ||
| N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Alterations, Cellular proliferation / hyperplasia | ||
| Changes/Inhibition, Cellular Homeostasis and Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects | ||
| Disruption, Lysosome | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Peptide Oxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | KE5 : Decrease, AKT/eNOS activity | ||
| KE5 : Decrease, AKT/eNOS activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | KE6 : Depletion, Nitric Oxide | ||
| Activation, EGFR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mucin production | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Early Life Stage Mortality | ||
| KE8 : Increase, Vascular Resistance | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hypertension | ||
| KE7 : Impaired, Vasodilation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | KE8 : Increase, Vascular Resistance | ||
| Peptide Oxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | KE2 : Decrease, GTPCH-1 | ||
| Impairment, Endothelial network | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Cardiovascular development/function | ||
| reduced production, VEGF | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Endothelial network | ||
| reduced dimerization, ARNT/HIF1-alpha | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | reduced production, VEGF | ||
| dimerization, AHR/ARNT | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | reduced dimerization, ARNT/HIF1-alpha | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | dimerization, AHR/ARNT | ||
| KE6 : Depletion, Nitric Oxide | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | KE7 : Impaired, Vasodilation | ||
| KE4 : Uncoupling, eNOS | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | KE6 : Depletion, Nitric Oxide | ||
| KE1 : S-Glutathionylation, eNOS | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | KE4 : Uncoupling, eNOS | ||
| KE3 : Decrease, Tetrahydrobiopterin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | KE4 : Uncoupling, eNOS | ||
| KE2 : Decrease, GTPCH-1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | KE3 : Decrease, Tetrahydrobiopterin | ||
| Inhibition, Cyclooxygenase activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Prostaglandin E2 concentration | ||
| Reduction, Cumulative fecundity and spawning | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Inhibition, NADH-ubiquinone oxidoreductase (complex I) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, NADH-ubiquinone oxidoreductase (complex I) | ||
| Peptide Oxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cholestasis, Pathology | ||
| Bile accumulation, Pathological condition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Production, Reactive oxygen species | ||
| Production, Critical Metabolites (CGA 330050 and CGA 265307) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, Liver “Dysfunctional” Changes by CGA 330050 | ||
| Increase, Inflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cholestasis, Pathology | ||
| Bile accumulation, Pathological condition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Release, Cytokine | ||
| Inhibition, Bile Salt Export Pump (ABCB11) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Bile accumulation, Pathological condition | ||
| Binding of agonist, Ionotropic glutamate receptors | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Overactivation, NMDARs | ||
| Degeneration of dopaminergic neurons of the nigrostriatal pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Parkinsonian motor deficits | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Degeneration of dopaminergic neurons of the nigrostriatal pathway | ||
| Degeneration of dopaminergic neurons of the nigrostriatal pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neuroinflammation | ||
| Neuroinflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Degeneration of dopaminergic neurons of the nigrostriatal pathway | ||
| Impaired, Proteostasis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Degeneration of dopaminergic neurons of the nigrostriatal pathway | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired, Proteostasis | ||
| Alkylation, DNA | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cancer | ||
| Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Mitochondrial fatty acid beta-oxidation | ||
| Increase, Mutations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cancer | ||
| Activation, SHP | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, SREBP1c | ||
| Increase, Cell Proliferation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Site of Contact Nasal Tumors | ||
| Increase, Mutations in Critical Genes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Site of Contact Nasal Tumors | ||
| Increase, Cell Proliferation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mutations in Critical Genes | ||
| Increase, Respiratory or Squamous Metaplasia | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell Proliferation | ||
| Increase, Tissue Degeneration, Necrosis & Atrophy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Respiratory or Squamous Metaplasia | ||
| Increase, Cytotoxicity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Tissue Degeneration, Necrosis & Atrophy | ||
| Decrease, Intracellular pH | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cytotoxicity | ||
| Increased, Catabolism of Muscle Protein | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Body Weight | ||
| Not Increased, Circulating Ketone Bodies | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Catabolism of Muscle Protein | ||
| Decreased, Ketogenesis (production of ketone bodies) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Not Increased, Circulating Ketone Bodies | ||
| Decreased, PPARalpha transactivation of gene expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Ketogenesis (production of ketone bodies) | ||
| Activation, Long term AHR receptor driven direct and indirect gene expression changes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Formation, Hepatocellular and Bile duct tumors | ||
| Activation, Long term AHR receptor driven direct and indirect gene expression changes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Alterations, Cellular proliferation / hyperplasia | ||
| Activation, Long term AHR receptor driven direct and indirect gene expression changes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Changes/Inhibition, Cellular Homeostasis and Apoptosis | ||
| Decrease of Thyroidal iodide | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Thyroid hormone synthesis, Decreased | ||
| Decrease of GABAergic interneurons | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of synaptogenesis | ||
| Reduced levels of BDNF | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of GABAergic interneurons | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, CYP1A2/CYP1A5 | ||
| Induction, CYP1A2/CYP1A5 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Oxidation, Uroporphyrinogen | ||
| Accumulation, Highly carboxylated porphyrins | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Uroporphyria | ||
| Oxidation, Uroporphyrinogen | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, UROD | ||
| Formation, Mallory body | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Formation, Liver fibrosis | ||
| Induction, Microvesicular fat | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Formation, Liver fibrosis | ||
| Occurrence, Cytoplasmic vacuolization (kupffer cell) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Formation, Mallory body | ||
| Occurrence, Cytoplasmic vacuolization (kupffer cell) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, Microvesicular fat | ||
| Occurrence, Cytoplasmic vacuolization (Bile duct cell) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Formation, Mallory body | ||
| Occurrence, Cytoplasmic vacuolization (Bile duct cell) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, Microvesicular fat | ||
| Occurrence, Ballooning degeneration (hepatocyte) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Formation, Mallory body | ||
| Occurrence, Ballooning degeneration (hepatocyte) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, Microvesicular fat | ||
| Occurrence, Cytoplasmic vacuolization (hepatocyte) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Formation, Mallory body | ||
| Occurrence, Cytoplasmic vacuolization (hepatocyte) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, Microvesicular fat | ||
| Disturbance, Lysosomal function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Cytoplasmic vacuolization (kupffer cell) | ||
| Disturbance, Lysosomal function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Cytoplasmic vacuolization (Bile duct cell) | ||
| Disturbance, Lysosomal function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Ballooning degeneration (hepatocyte) | ||
| Disturbance, Lysosomal function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Cytoplasmic vacuolization (hepatocyte) | ||
| Damage, Lipid bilayer | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Cytoplasmic vacuolization (kupffer cell) | ||
| Damage, Lipid bilayer | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Cytoplasmic vacuolization (Bile duct cell) | ||
| Damage, Lipid bilayer | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Ballooning degeneration (hepatocyte) | ||
| Damage, Lipid bilayer | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Cytoplasmic vacuolization (hepatocyte) | ||
| Inhibition, Phospholipase A | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Disturbance, Lysosomal function | ||
| Inhibition, Phospholipase A | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Damage, Lipid bilayer | ||
| Activation/Proliferation, T-cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | sensitisation, skin | ||
| Activation, Keratinocytes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, Dendritic Cells | ||
| Covalent Binding, Protein | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, Keratinocytes | ||
| Decreased, Renal ability to dilute urine | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Kidney toxicity | ||
| Decreased, Sodium reabsorption | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Kidney toxicity | ||
| Decreased, Renal plasma flow | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Kidney toxicity | ||
| Decreased, Glomerular filtration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Kidney toxicity | ||
| Occurrence, Cytoplasmic vacuolization (podocyte) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Renal ability to dilute urine | ||
| Occurrence, Cytoplasmic vacuolization (podocyte) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Sodium reabsorption | ||
| Occurrence, Cytoplasmic vacuolization (podocyte) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Renal plasma flow | ||
| Occurrence, Cytoplasmic vacuolization (podocyte) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Glomerular filtration | ||
| Occurrence, Cystic dilatation (renal tubule) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Renal ability to dilute urine | ||
| Occurrence, Cystic dilatation (renal tubule) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Sodium reabsorption | ||
| Occurrence, Cystic dilatation (renal tubule) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Renal plasma flow | ||
| Occurrence, Cystic dilatation (renal tubule) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Glomerular filtration | ||
| Occurrence, Cytoplasmic vacuolization (Renal tubule) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Renal ability to dilute urine | ||
| Accumulation, Collagen | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Liver fibrosis | ||
| Occurrence, Cytoplasmic vacuolization (Renal tubule) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Sodium reabsorption | ||
| Occurrence, Cytoplasmic vacuolization (Renal tubule) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Renal plasma flow | ||
| Occurrence, Cytoplasmic vacuolization (Renal tubule) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Glomerular filtration | ||
| Increased, Serum creatinine | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Cytoplasmic vacuolization (podocyte) | ||
| Increased, Serum creatinine | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Cystic dilatation (renal tubule) | ||
| Increased, Serum creatinine | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Cytoplasmic vacuolization (Renal tubule) | ||
| Thyroid hormone synthesis, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Serum creatinine | ||
| malformed, Male reproductive tract | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Fertility | ||
| Decreased, mevalonate | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, cholesterol | ||
| Inhibition, HMG-CoA reductase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, mevalonate | ||
| Increased, HIF-1 alpha transcription | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, HIF-1 heterodimer | ||
| modulation, Unknown | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, HIF-1 alpha transcription | ||
| Decreased, Aromatase (Cyp19a1) mRNA | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | ||
| Increased, HIF-1 heterodimer | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Aromatase (Cyp19a1) mRNA | ||
| Inhibition, Prolyl hydroxylases | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, HIF-1 heterodimer | ||
| Increase, Hyperplasia (urothelial) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Adenomas/carcinomas (urothelial) | ||
| Increase, Regenerative cell proliferation (urothelial cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Hyperplasia (urothelial) | ||
| Increase, Cytotoxicity (urothelial cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Regenerative cell proliferation (urothelial cells) | ||
| Increase, Urinary bladder calculi | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cytotoxicity (urothelial cells) | ||
| Increased, Leutinizing hormone (LH) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Hyperplasia (Leydig cells) | ||
| Decrease, Bioactivation of testosterone | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Leutinizing hormone (LH) | ||
| Inhibition, 5α-reductase activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Bioactivation of testosterone | ||
| Increase, Regenerative cell proliferation (hepatocytes) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Preneoplastic foci (hepatocytes) | ||
| Increase, Cytotoxicity (hepatocytes) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Regenerative cell proliferation (hepatocytes) | ||
| Activation, Androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, cell proliferation (hepatocytes) | ||
| Increase, Hyperplasia (tubular epithelial cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Adenomas/carcinomas (renal tubular) | ||
| Increase, Regenerative cell proliferation (tubular epithelial cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Hyperplasia (tubular epithelial cells) | ||
| Increase, Cytotoxicity (tubular epithelial cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Regenerative cell proliferation (tubular epithelial cells) | ||
| Increase, Hyperplasia (forestomach epithelial cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Papillomas/carcinomas (squamous cells) | ||
| Increase, Regenerative cell proliferation (forestomach epithelial cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Hyperplasia (forestomach epithelial cells) | ||
| Increase, Inflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Regenerative cell proliferation (forestomach epithelial cells) | ||
| Increase, Cytotoxicity (epithelial cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Inflammation | ||
| Increase, Regenerative cell proliferation (corneal cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Papillomas/carcinomas (squamous cells) | ||
| Increase, Inflammation (corneal cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Regenerative cell proliferation (corneal cells) | ||
| Increase, Cytotoxicity (corneal cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Inflammation (corneal cells) | ||
| Increased, Plasma tyrosine | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cytotoxicity (corneal cells) | ||
| Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Plasma tyrosine | ||
| Increase, Preneoplastic foci (hepatocytes) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, hepatocellular adenomas and carcinomas | ||
| Increase, cell proliferation (hepatocytes) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Preneoplastic foci (hepatocytes) | ||
| Decreased, Progesterone from corpus luteum | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Hyperplasia (glandular epithelial cells of endometrium) | ||
| Increase, Hyperplasia (glandular epithelial cells of endometrium) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Endometrial adenocarcinomas | ||
| Activation, ChREBP | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Synthesis, De Novo Fatty Acid (FA) | ||
| Increase, Cytotoxicity (club cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Necrosis (terminal bronchiolar cells) | ||
| Increase, Cytotoxicity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, hepatocellular adenomas and carcinomas | ||
| Peptide Oxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cytotoxicity | ||
| Increase, Oxidative metabolism | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Peptide Oxidation | ||
| Increased, Induction of pyruvate dehydrogenase (PDH) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oxidative metabolism | ||
| Increase, Hyperplasia (renal tubular cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Adenomas/carcinomas (renal tubular) | ||
| Increase, Regenerative cell proliferation (tubular epithelial cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Hyperplasia (renal tubular cells) | ||
| Increased, Chloride conductance | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | hyperpolarisation, neuron | ||
| N/A, Ataxia, paralysis, or hyperactivity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Mortality | ||
| Increased Mortality | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, population 1 | ||
| hyperpolarisation, neuron | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Ataxia, paralysis, or hyperactivity | ||
| Activation, Glutamate-gated chloride channel | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Chloride conductance | ||
| N/A, Unknown | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Kidney Failure | ||
| Activation, 5HT2c | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Unknown | ||
| Hippocampal anatomy, Altered | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hippocampal Physiology, Altered | ||
| Hippocampal Physiology, Altered | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cognitive Function, Decreased | ||
| Hippocampal gene expression, Altered | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hippocampal anatomy, Altered | ||
| Thyroxine (T4) in neuronal tissue, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hippocampal gene expression, Altered | ||
| Increased, Luteinizing hormone (LH) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Hyperplasia (Leydig cells) | ||
| Decreased, Testosterone binding to androgen receptor (hypothalamus) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Luteinizing hormone (LH) | ||
| Increase, Hyperplasia (follicular cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Adenomas/carcinomas (follicular cell) | ||
| Increase, Hypertrophy and proliferation (follicular cell) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Hyperplasia (follicular cells) | ||
| Altered, Meiotic chromosome dynamics | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Chromosome number | ||
| Disorganization, Meiotic Spindle | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Meiotic chromosome dynamics | ||
| Increased, Estrogen receptor (ER) activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Progesterone from corpus luteum | ||
| Decreased, Prolactin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Estrogen receptor (ER) activity | ||
| Increase, Dopaminergic activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Prolactin | ||
| Increase, Hyperplasia (Leydig cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Leydig cell tumors | ||
| Decreased, Androgen receptor activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Testosterone binding to androgen receptor (hypothalamus) | ||
| Increase, Hyperplasia (terminal bronchiolar cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Adenomas/carcinomas (bronchioloalveolar) | ||
| Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Hyperplasia (terminal bronchiolar cells) | ||
| Increase, Necrosis (terminal bronchiolar cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) | ||
| Binding, Tubulin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Chromosome number | ||
| Altered, Chromosome number | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Aneuploid offspring | ||
| Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Induction of pyruvate dehydrogenase (PDH) | ||
| Disruption, Microtubule dynamics | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Disorganization, Meiotic Spindle | ||
| Binding, Tubulin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Disruption, Microtubule dynamics | ||
| Increase, Cytotoxicity (renal tubular cell) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Regenerative cell proliferation (tubular epithelial cells) | ||
| Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cytotoxicity (renal tubular cell) | ||
| Increased, Binding of chemicals to 2u (serum) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) | ||
| Increased, cardiac arrthymia | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Mortality | ||
| Altered, Action Potential | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, cardiac arrthymia | ||
| impaired, ion channels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Action Potential | ||
| Increased, Chromosome misseggregation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Reproductive Success | ||
| Upregulated, Spindle assembly checkpoint protein Mad2-oocyte | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Chromosome misseggregation | ||
| Reduced, Maturation inducing steroid receptor signalling, oocyte | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Upregulated, Spindle assembly checkpoint protein Mad2-oocyte | ||
| Reduced, Meiotic prophase I/metaphase I transition, oocyte | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Reproductive Success | ||
| Increased, cyclic adenosine monophosphate | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Meiotic prophase I/metaphase I transition, oocyte | ||
| Reduced, Maturation inducing steroid receptor signalling, oocyte | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, cyclic adenosine monophosphate | ||
| Reduced, Maturation inducing steroid, plasma | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Maturation inducing steroid receptor signalling, oocyte | ||
| Reduced, Luteinizing hormone (LH), plasma | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Maturation inducing steroid, plasma | ||
| Reduced, Gonadotropin releasing hormone, hypothalamus | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Luteinizing hormone (LH), plasma | ||
| Reduced, Prostaglandin E2 concentration, hypothalamus | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Gonadotropin releasing hormone, hypothalamus | ||
| Proliferation, Cell proliferation in the absence of cytotoxicity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hyperplasia, Hyperplasia | ||
| Inhibition, Cyclooxygenase activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Prostaglandin E2 concentration, hypothalamus | ||
| Decrease, Ovulation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Reproductive Success | ||
| Inhibition, Cyclooxygenase activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Prostaglandins, ovary | ||
| Reduced, Prostaglandins, ovary | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Ovulation | ||
| Generation, Amplified excitatory postsynaptic potential (EPSP) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, A paroxysmal depolarizing shift | ||
| Reduction, Neuronal synaptic inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Generation, Amplified excitatory postsynaptic potential (EPSP) | ||
| Decreased, Prostaglandin F2alpha synthesis, ovary | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Prostaglandin F2alpha concentration, plasma | ||
| Inhibition, Cyclooxygenase activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Prostaglandin F2alpha synthesis, ovary | ||
| Cell injury/death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, Stellate cells | ||
| Reduced, Pheromone release | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Ability to attract spawning mates | ||
| Reduced, Prostaglandin F2alpha concentration, plasma | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Pheromone release | ||
| Reduced, Reproductive Success | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Reduced, Ability to attract spawning mates | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Reproductive Success | ||
| Reduced, Spawning behavior | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Ability to attract spawning mates | ||
| Reduced, Prostaglandin F2alpha concentration, plasma | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Spawning behavior | ||
| Reduced, Prostaglandin F2alpha synthesis, ovary | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Prostaglandin F2alpha concentration, plasma | ||
| Inhibition, Cyclooxygenase activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Prostaglandin F2alpha synthesis, ovary | ||
| Reduction, Ionotropic GABA receptor chloride channel conductance | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Neuronal synaptic inhibition | ||
| Binding at picrotoxin site, iGABAR chloride channel | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Ionotropic GABA receptor chloride channel conductance | ||
| Accelerated, Aging | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Number of worker bees | ||
| Accumulation, Damaged mitochondrial DNA | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accelerated, Aging | ||
| Overwhelmed, Mitochondrial DNA repair mechanisms | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Damaged mitochondrial DNA | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Overwhelmed, Mitochondrial DNA repair mechanisms | ||
| Up Regulation, CD36 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, FA Influx | ||
| Desensitization, Nicotinic acetylcholine receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of neuronal network function | ||
| Activation, Nicotinic acetylcholine receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Desensitization, Nicotinic acetylcholine receptor | ||
| Increased, predation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, survival | ||
| Decreased, locomotion | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, predation | ||
| N/A, sedation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, locomotion | ||
| Decrease, histaminergic neuron excitation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, sedation | ||
| N/A, Neurodegeneration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Neuronal network function in adult brain | ||
| Decreased, sheltering | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, predation | ||
| Decreased, anxiety | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, sheltering | ||
| Increased, serotonin (5-HT) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, anxiety | ||
| Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, serotonin (5-HT) | ||
| Increased, muscular waves in foot | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, foot detachment | ||
| Increased, muscular waves in foot | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, locomotion | ||
| Increased, locomotion | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, predation | ||
| Decreased, Neuronal network function in adult brain | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Occurrence, A paroxysmal depolarizing shift | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Epileptic seizure | ||
| Inhibition, Ca++ ATPase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Ca++ (intracellular) | ||
| Increased, Ataxia, paralysis, or hyperactivity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Mortality | ||
| Overactivation, muscle contraction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Ataxia, paralysis, or hyperactivity | ||
| Overactivation, Neuronotransmitter release | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Overactivation, muscle contraction | ||
| prolonged, Depolarization of neuronal membrane | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Overactivation, Neuronotransmitter release | ||
| modulation, sodium channel | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | prolonged, Depolarization of neuronal membrane | ||
| Increase, Ca++ (intracellular) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Disruption, Mitochondrial electron transport chain | ||
| Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Sodium conductance 1 | ||
| Reduced, feeding 1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, survival | ||
| Increased, predation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, survival | ||
| Decreased, Sodium conductance 1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Atrioventricular block and bradycardia | ||
| N/A, hypoxia | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, amputations | ||
| Respiratory distress/arrest | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, hypoxia | ||
| Increased, Atrioventricular block and bradycardia | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Respiratory distress/arrest | ||
| Reduction, Ca and HCO3 transport to shell gland | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Eggshell thickness | ||
| Reduced, feeding 1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, predation | ||
| Reduced, swimming speed | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, predation | ||
| Reduced, swimming speed | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, feeding 1 | ||
| Decreased, Sodium conductance 1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, swimming speed | ||
| Inhibition, sodium channel | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Sodium conductance 1 | ||
| Impairment, Learning and memory | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Abnormal, Foraging activity and behavior | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of neuronal network function | ||
| Activation, Nicotinic acetylcholine receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Abnormal, Roll change within caste | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Food storage | ||
| Reduced, Antiseptic incorporated in food | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Abnormal, Roll change within caste | ||
| Decreased, Hydrogen peroxide production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Antiseptic incorporated in food | ||
| Decreased, Glucose oxidase enzyme activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Hydrogen peroxide production | ||
| Increased, Viral susceptibility | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Abnormal, Foraging activity and behavior | ||
| impaired, Hive thermoregulation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Death/Failure, Colony | ||
| Decrease, Number of worker bees | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Hive thermoregulation | ||
| impaired, Development | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Number of worker bees | ||
| Increased, Viral susceptibility | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Development | ||
| Suppression, Immune system | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Viral susceptibility | ||
| Abnormal, Foraging activity and behavior | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Number of worker bees | ||
| Increased, Appetite and hunger | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Abnormal, Foraging activity and behavior | ||
| Increase, Energetic demands and therefore metabolic stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Appetite and hunger | ||
| Reduced, Brood care | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Larval development | ||
| Abnormal, Roll change within caste | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Brood care | ||
| Impairment, Learning and memory | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Abnormal, Roll change within caste | ||
| impaired, Larval development | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Death/Failure, Colony | ||
| Reduced, Food storage | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Larval development | ||
| Decrease, Number of worker bees | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Death/Failure, Colony | ||
| Inhibition, Na+/I- symporter (NIS) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Thyroid hormone synthesis, Decreased | ||
| Formation, Pro-mutagenic DNA Adducts | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) | ||
| Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Tumorigenesis, Hepatocellular carcinoma | ||
| Increased, Induced Mutations in Critical Genes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) | ||
| Formation, Pro-mutagenic DNA Adducts | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts | ||
| Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Induced Mutations in Critical Genes | ||
| systemic inflammation leading to hepatic steatosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, AKT2 | ||
| Inhibition, Mitochondrial fatty acid beta-oxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Liver Steatosis | ||
| Decreased, DHB4/HSD17B4 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, Mitochondrial fatty acid beta-oxidation | ||
| Activation, PPARα | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, LXR alpha | ||
| Activation, NR1H4 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, PPARα | ||
| Activation, NR1H4 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, SHP | ||
| Activation, NRF2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, NR1H4 | ||
| Activation, PXR/SXR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Up Regulation, CD36 | ||
| Activation, PXR/SXR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Up Regulation, SCD-1 | ||
| Down Regulation, HMGCS2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Ketogenesis | ||
| Inhibition, FoxA2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Down Regulation, HMGCS2 | ||
| Down Regulation, CPT1A | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Mitochondrial fatty acid beta-oxidation | ||
| Inhibition, FoxA2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Down Regulation, CPT1A | ||
| Activation, PXR/SXR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, FoxA2 | ||
| Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, De Novo FA synthesis | ||
| Activation, LXR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) | ||
| Accumulation, Fatty acid | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Liver Steatosis | ||
| Accumulation, Fatty acid | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Triglyceride formation | ||
| Increased, De Novo FA synthesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Fatty acid | ||
| Inhibition, PPAR alpha | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, Mitochondrial fatty acid beta-oxidation | ||
| Activation, LXR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, PPAR alpha | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Suppression, VLDL secretion | ||
| Increased, LDL uptake | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Fatty acid | ||
| Up Regulation, LDLR (low density lipoprotein receptor) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, LDL uptake | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Up Regulation, LDLR (low density lipoprotein receptor) | ||
| Increased, FA Influx | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Fatty acid | ||
| Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Fatty acid | ||
| Up Regulation, CD36 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, FA Influx | ||
| Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Plasma 17beta-estradiol concentrations | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Up Regulation, CD36 | ||
| Up Regulation, SCD-1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Triglyceride formation | ||
| Up Regulation, FAS | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, De Novo FA synthesis | ||
| Activation, LXR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Up Regulation, SCD-1 | ||
| Activation, LXR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Up Regulation, FAS | ||
| Activation, SREBF1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Up Regulation, SCD-1 | ||
| peroxisome proliferator activated receptor promoter demethylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, SREBF1 | ||
| Increased, Triglyceride formation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Liver Steatosis | ||
| Activation, ChREBP | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, De Novo FA synthesis | ||
| Activation, LXR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, SREBF1 | ||
| Suppression, Constitutive androstane receptor, NR1l3 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | peroxisome proliferator activated receptor promoter demethylation | ||
| Suppression, Constitutive androstane receptor, NR1l3 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, LXR | ||
| Inhibition, Mitochondrial fatty acid beta-oxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Fatty acid | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, Mitochondrial fatty acid beta-oxidation | ||
| Accumulation, Fatty acid | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Triglyceride | ||
| Hyperplasia, Leydig cell | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Fertility | ||
| Increase, Luteinizing hormone (LH) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase proliferation, Leydig cell | ||
| Acetylcholine accumulation in synapses | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Acetylcholinesterase (AchE) Inhibition | ||
| Increased Cholinergic Signaling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Respiratory distress/arrest | ||
| Acetylcholine accumulation in synapses | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Cholinergic Signaling | ||
| Acetylcholinesterase (AchE) Inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Mortality | ||
| Acetylcholinesterase (AchE) Inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Cholinergic Signaling | ||
| Acetylcholinesterase (AchE) Inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Respiratory distress/arrest | ||
| Inhibition, Aromatase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | ||
| Reduced levels of BDNF | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of synaptogenesis | ||
| Thyroxine (T4) in neuronal tissue, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced levels of BDNF | ||
| Inhibition, Na+/I- symporter (NIS) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of Thyroidal iodide | ||
| Reduction, Testosterone synthesis in Leydig cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, fetal/adult testosterone | ||
| Reduction, Cholesterol transport in mitochondria | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Testosterone synthesis in Leydig cells | ||
| Decrease, Translocator protein (TSPO) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Cholesterol transport in mitochondria | ||
| Decrease, Steroidogenic acute regulatory protein (STAR) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Cholesterol transport in mitochondria | ||
| Respiratory distress/arrest | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Mortality | ||
| peroxisome proliferator activated receptor promoter demethylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Up Regulation, CD36 | ||
| Malformation, Male reproductive tract | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Fertility | ||
| Thyroxine (T4) in serum, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cognitive Function, Decreased | ||
| Metabolism of AFB1, Production of Reactive Electrophiles | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Formation, Pro-mutagenic DNA Adducts | ||
| Increase proliferation, Leydig cell | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hyperplasia, Leydig cell | ||
| reduction in ovarian granulosa cells, Aromatase (Cyp19a1) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | ||
| irregularities, ovarian cycle | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Fertility | ||
| Reduction, Plasma 17beta-estradiol concentrations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | irregularities, ovarian cycle | ||
| Decreased, Lymphocytes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Suppression, Immune system | ||
| Suppression, Inflammatory cytokines | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Lymphocytes | ||
| Inhibition, Nuclear factor kappa B (NF-kB) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Suppression, Inflammatory cytokines | ||
| Induction, IKB inhibitory protein | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, Nuclear factor kappa B (NF-kB) | ||
| Activation, Glucocorticoid Receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, IKB inhibitory protein | ||
| Altered, Neurophysiology | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cognitive Function, Decreased | ||
| Activation, Dendritic Cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation/Proliferation, T-cells | ||
| Covalent Binding, Protein | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, Dendritic Cells | ||
| Activation, PPARα | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Translocator protein (TSPO) | ||
| Activation, PPARα | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Steroidogenic acute regulatory protein (STAR) | ||
| Thyroperoxidase, Inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Thyroxine (T4) in serum, Decreased | ||
| Cell injury/death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neuroinflammation | ||
| Cell injury/death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Neurodegeneration | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| Increased, Intracellular Calcium overload | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Overactivation, NMDARs | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Intracellular Calcium overload | ||
| Reduction, Angiogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Endothelial network | ||
| Decrease of neuronal network function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Decrease of synaptogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of neuronal network function | ||
| Reduced, Presynaptic release of glutamate | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of synaptogenesis | ||
| Aberrant, Dendritic morphology | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of synaptogenesis | ||
| Cell injury/death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of synaptogenesis | ||
| Reduced levels of BDNF | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Presynaptic release of glutamate | ||
| Reduced levels of BDNF | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| N/A, Androgen receptor, Antagonism | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Alteration, Wnt pathway | ||
| Reduced levels of BDNF | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Aberrant, Dendritic morphology | ||
| Decreased, Calcium influx | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced levels of BDNF | ||
| Increased, Induced Mutations in Critical Genes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Tumorigenesis, Hepatocellular carcinoma | ||
| Formation, Pro-mutagenic DNA Adducts | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Tumorigenesis, Hepatocellular carcinoma | ||
| Alteration, Wnt pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Feminisation or incomplete development, Primary and accessory male sex organs | ||
| Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Cumulative fecundity and spawning | ||
| Increase, Vitellogenin synthesis in liver | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Plasma vitellogenin concentrations | ||
| Inhibition, VegfR2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Angiogenesis | ||
| N/A, Androgen receptor, Antagonism | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Transcription of genes by the androgen receptor | ||
| N/A, Unknown | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Proliferation, Cell proliferation in the absence of cytotoxicity | ||
| Suppression, VLDL secretion | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Liver Steatosis | ||
| Reduced, fatty acid beta oxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Liver Steatosis | ||
| Decrease, testosterone levels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma | ||
| Decrease, testosterone levels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Plasma 17beta-estradiol concentrations | ||
| Increase, Gonadotropins concentration in plasma | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, testosterone levels | ||
| Disrupted Lipid Storage | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Triglyceride | ||
| Disrupted Lipid Storage | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Fatty acid | ||
| Decreased, Mitochondrial fatty acid beta-oxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Disrupted Lipid Storage | ||
| PFOS binding PPAR isoforms resulting in disrupted nuclear signaling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Mitochondrial fatty acid beta-oxidation | ||
| PFOS binding PPAR isoforms resulting in disrupted nuclear signaling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Dysregulation of transcriptional expression within PPAR signaling network | ||
| Decrease, testosterone levels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Luteinizing hormone (LH) | ||
| Decrease, testosterone levels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Malformation, Male reproductive tract | ||
| Epithelial Mesenchymal Transition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Airway remodeling | ||
| Non-coding RNA expression profile alteration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Epithelial Mesenchymal Transition | ||
| Decrease, testosterone levels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | malformed, Male reproductive tract | ||
| Decreased, cholesterol | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, testosterone levels | ||
| Epithelial Mesenchymal Transition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Treatment-resistant gastric cancer | ||
| Agonism, Androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Testosterone synthesis by ovarian theca cells | ||
| beta-catenin activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Epithelial Mesenchymal Transition | ||
| Cell injury/death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Intestinal barrier, disruption | ||
| Altered, cholesterol metabolism | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered Liver X receptor activity | ||
| Binding of (ant)agonist to peroxisome proliferator–activated receptor alpha | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced number of oligodendrocytes | ||
| Altered Liver X receptor activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced number of oligodendrocytes | ||
| Antagonism, Thyroid Receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hypomyelination | ||
| Altered, white brain matter | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Hypomyelination | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, white brain matter | ||
| Reduced number of oligodendrocytes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hypomyelination | ||
| Activation of specific nuclear receptors, Transcriptional change | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cholestasis, Pathology | ||
| Altered, cholesterol metabolism | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced number of oligodendrocytes | ||
| Binding of (ant)agonist to peroxisome proliferator–activated receptor alpha | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, cholesterol metabolism | ||
| Binding of (ant)agonist to liver X receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, cholesterol metabolism | ||
| Antagonism, Thyroid Receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced number of oligodendrocytes | ||
| Binding of (ant)agonist to peroxisome proliferator–activated receptor alpha | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered peroxisome proliferator–activated receptor alpha activity | ||
| Binding of (ant)agonist to liver X receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered Liver X receptor activity | ||
| Binding of antagonist to glucocorticoid hormone receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Antagonism, Glucocorticoid hormone receptor | ||
| Binding of antagonist to thyroid hormone receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Antagonism, Thyroid Receptor | ||
| Insulin resistance, increased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Metabolic syndrome | ||
| Impaired insulin signaling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Insulin resistance, increased | ||
| Insulin resistance, increased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Metabolically unhealthy Obesity | ||
| Increase in inflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Insulin resistance, increased | ||
| Decrease, Cardiac contractility | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease Left Ventricular function | ||
| Decreased, Insulin-like peptide 3 (INSL3) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired inguinoscrotal testicular descent phase | ||
| Impaired, urethral tube closure | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hypospadias, increased | ||
| Decrease, dihydrotestosterone (DHT) level | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired, urethral tube closure | ||
| Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, dihydrotestosterone (DHT) level | ||
| Epididymal agenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired, Spermatogenesis | ||
| Altered, Transcription of genes by the androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Alteration, Wnt pathway | ||
| Decrease, testosterone levels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Epididymal agenesis | ||
| Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, testosterone levels | ||
| Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells | ||
| Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, Nuclear factor kappa B (NF-kB) | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered gene expression, NRF2 dependent antioxidant pathway | ||
| Decrease, Mitochondrial membrane potential | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Accumulation, Triglyceride | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired insulin signaling | ||
| Increased, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Altered, Transcription of genes by the androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Feminisation or incomplete development, Primary and accessory male sex organs | ||
| Decreased, Mitochondrial fatty acid beta-oxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Cytoplasmic vacuolization (Bile duct cell) | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Cytoplasmic vacuolization (kupffer cell) | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Ballooning degeneration (hepatocyte) | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Cytoplasmic vacuolization (hepatocyte) | ||
| Inhibition, Phospholipase A | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of ER stress | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Apoptotic cell death | ||
| benzoquinone imine and acylglucuronide metabolites | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Urothelial cell injury/death | ||
| Reduction, Vitellogenin synthesis in liver | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Plasma vitellogenin concentrations | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Necrosis | ||
| narcosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Decompartmentalization | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Apoptosis | ||
| Direct mitochondrial inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Agonism, Retinoic acid receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase risk, microcephaly | ||
| Reduced cortical thickness | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase risk, microcephaly | ||
| Granulosa cell proliferation of gonadotropin-independent follicles, Reduced | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | irregularities, ovarian cycle | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reactive oxygen species | ||
| Increase, intracellular calcium | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Increased, tumor growth | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | metastatic breast cancer | ||
| Increased, Invasion | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | metastatic breast cancer | ||
| Increase, angiogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | metastatic breast cancer | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Proteasomal dysfunction | ||
| Alkylation, Protein | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cytotoxicity (renal tubular cell) | ||
| Depletion, mtDNA | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased，Vascular endothelial dysfunction | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Apoptosis | ||
| Increase, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Decreased proliferation of cortical neural progenitor cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced cortical thickness | ||
| Inhibition, NMDARs | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Aberrant, synaptic formation and plasticity | ||
| Decrease of neuronal network function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | autism-like behavior | ||
| Aberrant, synaptic formation and plasticity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of neuronal network function | ||
| inhibition, EKR1/2 signaling pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Aberrant, synaptic formation and plasticity | ||
| Antagonism, Estrogen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | inhibition, EKR1/2 signaling pathway | ||
| Thyroxine (T4) in serum, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Thyroxine (T4) in neuronal tissue, Decreased | ||
| Increased, histomorphological alteration of testis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired, Spermatogenesis | ||
| Increased, Lipid peroxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, histomorphological alteration of testis | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Lipid peroxidation | ||
| Increased, essential element imbalance | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reactive oxygen species | ||
| Agonism, Retinoic acid receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Agonism, Retinoic acid receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased proliferation of cortical neural progenitor cells | ||
| Altered brain morphology | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Decreased proliferation of cortical neural progenitor cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered brain morphology | ||
| Altered expression of cell cycle genes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased proliferation of cortical neural progenitor cells | ||
| Agonism, Retinoic acid receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered expression of cell cycle genes | ||
| decline, neural progenitor cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase risk, microcephaly | ||
| Premature cell differentiation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | decline, neural progenitor cells | ||
| Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | decline, neural progenitor cells | ||
| Activation of Tumor Protein 53 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Apoptosis | ||
| Increased, Expression of LXR activated genes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Synthesis, De Novo Fatty Acid (FA) | ||
| Activation, LXR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Expression of LXR activated genes | ||
| Activation, Pregnane-X receptor, NR1l2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Up Regulation, CD36 | ||
| Agonism, Androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Gonadotropins, circulating concentrations | ||
| Increase, DNA double-strand breaks | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Caspase transcription | ||
| Increase, DNA methyltransferase inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, DNA double-strand breaks | ||
| Increase, Formation of DNA photoproducts | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, DNA double-strand breaks | ||
| Increase, DNA double-strand breaks | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Apoptosis | ||
| Increase, Oxidative DNA damage | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, DNA double-strand breaks | ||
| Alteration, lipid metabolism | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | General Apoptosis | ||
| Decreased, PPAR-gamma activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Alteration, lipid metabolism | ||
| Increased, Reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, PPAR-gamma activation | ||
| Increased, Intracellular Calcium overload | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Loss of drebrin | ||
| Increased, Neuronal synaptic inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, Feeding | ||
| Thyroperoxidase, Inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Thyroid hormone synthesis, Decreased | ||
| Induction, Somatic muscle paralysis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Neuronal synaptic inhibition | ||
| Activated, presynaptic neuron 1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Ionotropic GABA receptor chloride channel conductance | ||
| Inhibition, Feeding | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mortality | ||
| Activated, presynaptic neuron 1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, Glutamate-gated chloride channels | ||
| Activation, Glutamate-gated chloride channels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, CNS Neural cell death | ||
| Activation, Glutamate-gated chloride channels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Overactivation, NMDARs | ||
| Parkinsonian motor deficits | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mortality | ||
| Increased, epilepsy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mortality | ||
| N/A, Neurodegeneration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, seizure | ||
| Disruption, neurotransmitter release | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Learning and memory | ||
| impaired, Learning and memory | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Parkinsonian motor deficits | ||
| Synaptic dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Learning and memory | ||
| Degeneration of dopaminergic neurons of the nigrostriatal pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Learning and memory | ||
| Decreased, Neuronal network function in adult brain | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Learning and memory | ||
| N/A, Neurodegeneration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Learning and memory | ||
| Decreased, Neuronal network function in adult brain | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neuroinflammation | ||
| Decreased, Neuronal network function in adult brain | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neurological disorder | ||
| Overactivation, NMDARs | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neuroinflammation | ||
| N/A, Neurodegeneration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Overactivation, NMDARs | ||
| Overactivation, NMDARs | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Neuronal network function in adult brain | ||
| Overactivation, NMDARs | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Acetylcholinesterase (AchE) Inhibition | ||
| Sensory axonal peripheral neuropathy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Neuronal network function in adult brain | ||
| Synaptic dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired axonial transport | ||
| Acetylcholinesterase (AchE) Inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Synaptic dysfunction | ||
| Acetylcholinesterase (AchE) Inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, CNS Neural cell death | ||
| Oxidative Stress in Brain | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Neuronal network function in adult brain | ||
| Decrease, mbp | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Neurodegeneration | ||
| Decrease, sox10 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Neurodegeneration | ||
| Decrease, elavl3 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Neurodegeneration | ||
| Increase, CNS Neural cell death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, mbp | ||
| Increase, CNS Neural cell death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, sox10 | ||
| Increase, CNS Neural cell death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, elavl3 | ||
| Influenza A Virus (IAV) budding | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Influenza A Virus (IAV) shedding and transmission | ||
| Immune mechanisms antagonized by viral proteins | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Influenza A Virus production increased | ||
| Influenza A Virus production increased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Influenza A Virus (IAV) budding | ||
| Increased, secretion of proinflammatory mediators | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Systemic acute phase response | ||
| Activation, caspases | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell death | ||
| Increase, Cytochrome c release | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, caspases | ||
| Thyroid hormone synthesis, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Thyroxine (T4) in serum, Decreased | ||
| Mitochondrial Injury | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cytochrome c release | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Proteasomal dysfunction | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation of misfolded proteins | ||
| Accumulation of misfolded proteins | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, caspases | ||
| Accumulation of misfolded proteins | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Endoplasmic reticulum stress | ||
| Proteasomal dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation of misfolded proteins | ||
| Unfolded Protein Response | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, caspases | ||
| Opening, voltage-gated calcium channels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Intracellular Calcium overload | ||
| Increase, Cell membrane depolarization | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Opening, voltage-gated calcium channels | ||
| Overactivation, NMDARs | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell membrane depolarization | ||
| Inositol triphosphate receptor activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, glutamate | ||
| Ryanodine receptor activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, glutamate | ||
| NFE2/Nrf2 repression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of inflammation pathway | ||
| Increase, Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased，Vascular endothelial dysfunction | ||
| Increase, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Apoptosis | ||
| Angiogenesis dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Vascular disrupting effects | ||
| increased，Vascular endothelial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Angiogenesis dysfunction | ||
| Influenza A virus (IAV) cell entry | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Immune mechanisms antagonized by viral proteins | ||
| Impaired Platelet Aggregation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Vascular disrupting effects | ||
| Vascular barrier disruption | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Vascular disrupting effects | ||
| increased，Vascular endothelial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Vascular barrier disruption | ||
| Inhibition VEGF/VEGFR pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased，Vascular endothelial dysfunction | ||
| Activated AKT/ERK/PI3K pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased，Vascular endothelial dysfunction | ||
| KE4 : Uncoupling, eNOS | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased，Vascular endothelial dysfunction | ||
| Activated Wnt/Frizzled pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased，Vascular endothelial dysfunction | ||
| Activated BMP/TGF-beta pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased，Vascular endothelial dysfunction | ||
| Activated ANG/Tie2 pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased，Vascular endothelial dysfunction | ||
| Reduction, Testosterone synthesis by ovarian theca cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | ||
| increased，Vascular endothelial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired Platelet Aggregation | ||
| Increase, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition VEGF/VEGFR pathway | ||
| Increase, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activated AKT/ERK/PI3K pathway | ||
| Increase, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | KE4 : Uncoupling, eNOS | ||
| Increase, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activated Wnt/Frizzled pathway | ||
| Increase, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activated BMP/TGF-beta pathway | ||
| Increase, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, Dll4-Notch pathway | ||
| Increase, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activated ANG/Tie2 pathway | ||
| Increase, Reactive Oxygen Species production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oxidative Stress | ||
| Abnormal expression of NO | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased，Vascular endothelial dysfunction | ||
| Activation of Angiogenic cytokines | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased，Vascular endothelial dysfunction | ||
| Activation of angiopoietin like protein 4 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased，Vascular endothelial dysfunction | ||
| Activation of MMP-2 MMP-9 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased，Vascular endothelial dysfunction | ||
| Increase, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Abnormal expression of NO | ||
| Activation of PPAR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of Angiogenic cytokines | ||
| Activation of PPAR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of angiopoietin like protein 4 | ||
| Activation of PPAR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of MMP-2 MMP-9 | ||
| Induction, Sustained Hepatotoxicity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, Sustained Cell Proliferation | ||
| Activation of PPAR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oxidative Stress | ||
| peroxisome proliferator activated receptor promoter demethylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of PPAR | ||
| Activation, Dll4-Notch pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased，Vascular endothelial dysfunction | ||
| Activation Sema6A | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, Dll4-Notch pathway | ||
| Activation, HIF1α | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation Sema6A | ||
| NFE2/Nrf2 repression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, HIF1α | ||
| Activation of inflammation pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased，Vascular endothelial dysfunction | ||
| Increase, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of inflammation pathway | ||
| Induction, Sustained Cell Proliferation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Formation, Liver tumor | ||
| NFE2/Nrf2 repression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oxidative Stress | ||
| Influenza A Virus (IAV) binds sialic acid glycan receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Influenza A virus (IAV) cell entry | ||
| General Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cancer | ||
| Increase, Inflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | General Apoptosis | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Inflammation | ||
| Inhibition of Sulfotransferase E1 (SULT1E1) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, estrogens | ||
| Genomic instability | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Uterine adenocarcinoma (endometrioid adenocarcinoma Type I) | ||
| Increase, Hyperplasia (glandular epithelial cells of endometrium) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Genomic instability | ||
| Expression of factors ruling proliferation, modified | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Hyperplasia (glandular epithelial cells of endometrium) | ||
| Epigenetic modification process | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Expression of factors ruling proliferation, modified | ||
| Activation, estrogen receptor alpha | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Epigenetic modification process | ||
| Increase, intracellular calcium | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Apoptosis | ||
| Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Neurodegeneration | ||
| Increased, Reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Apoptosis | ||
| Substance interaction with the lung resident cell membrane components | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Atherosclerosis | ||
| Substance interaction with the lung resident cell membrane components | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Systemic acute phase response | ||
| Substance interaction with the lung resident cell membrane components | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Transcription of genes encoding acute phase proteins, Increased | ||
| Decrease, Sonic Hedgehog second messenger production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Apoptosis | ||
| Disruption, neurotransmitter release | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Increase, intracellular calcium | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Disruption, neurotransmitter release | ||
| Decrease of neuronal network function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neurological disorder | ||
| Oxidative Stress in Brain | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of neuronal network function | ||
| Increased intracelluar Iron accumulation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Oxidative Stress in Brain | ||
| Activation, Stellate cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Collagen | ||
| Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, intracellular calcium | ||
| Neuronal dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neurological disorder | ||
| Increased intracelluar Iron accumulation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neuronal dysfunction | ||
| Activation, SREBP-1c | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Synthesis, De Novo Fatty Acid (FA) | ||
| Increased LCN2/iron complex binds to SLC22A17 receptor in neuron | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased intracelluar Iron accumulation | ||
| Decreased, Viable Offspring | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Impaired, Spermatogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Viable Offspring | ||
| Increased, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired insulin signaling | ||
| Estrogen receptor alpha inactivation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reactive oxygen species | ||
| Estrogen receptor alpha inactivation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Mitochondrial fatty acid beta-oxidation | ||
| Suppression of T cell activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, T-cell dependent antibody response | ||
| Agonism, Androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma | ||
| Reduction, Cumulative fecundity and spawning | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Population trajectory | ||
| Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Plasma vitellogenin concentrations | ||
| Reduction, Plasma 17beta-estradiol concentrations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma | ||
| Increased, gene expression of AR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Gonadotropins concentration in plasma | ||
| Agonism, Androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, gene expression of AR | ||
| Inflamatory events in light-exposed tissues | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | prostatic intraepithelial neoplasia | ||
| Inflamatory events in light-exposed tissues | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Invasion | ||
| Activation, Androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inflamatory events in light-exposed tissues | ||
| Decreased, Apoptosis (Epithelial Cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Alterations, Cellular proliferation / hyperplasia | ||
| Activation, Androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Apoptosis (Epithelial Cells) | ||
| prostatic intraepithelial neoplasia | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Prostate cancer | ||
| Alterations, Cellular proliferation / hyperplasia | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | prostatic intraepithelial neoplasia | ||
| Increase, Androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Alterations, Cellular proliferation / hyperplasia | ||
| Altered, Transcription of genes by the androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Androgen receptor | ||
| Activation, Androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Transcription of genes by the androgen receptor | ||
| Induction, CYP1A2/CYP1A5 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oxidative Stress | ||
| Estrogen receptor alpha inactivation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased lipid accumulation | ||
| Increased, recruitment of inflammatory cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase in inflammation | ||
| Increased pro-inflammatory cytokine expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase in inflammation | ||
| Increased fat mass | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased pro-inflammatory cytokine expression | ||
| increased lipid accumulation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased fat mass | ||
| Increased adipocyte size | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased fat mass | ||
| Increased adipocyte numbers | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased fat mass | ||
| Increase, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Thyroid hormone synthesis, Decreased | ||
| Superoxide generation, increased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oxidative Stress | ||
| Antagonism, Smoothened receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Orofacial clefting | ||
| Activation, Stellate cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, extracellular matrix deposition | ||
| Leukocyte recruitment/activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, extracellular matrix deposition | ||
| Cell injury/death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Leukocyte recruitment/activation | ||
| N/A, Liver Steatosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Liver Steatosis | ||
| Up Regulation, CYP1A1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Reactive oxygen species | ||
| Hippocampal gene expression, Altered | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hippocampal Physiology, Altered | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, Upregulation of glucuronyltransferase activity | ||
| Decrease, GLI1/2 target gene expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Apoptosis | ||
| Estrogen receptor alpha inactivation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased adipocyte numbers | ||
| Estrogen receptor alpha inactivation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased adipocyte size | ||
| Increased, Lipid peroxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Fertility | ||
| Depletion, GSH | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reactive oxygen species | ||
| Conjugation, GSH | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Depletion, GSH | ||
| Increased fat mass | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, recruitment of inflammatory cells | ||
| Cell injury/death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hippocampal Physiology, Altered | ||
| Impairment, Learning and memory | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | decreased, Intellectual Quotient | ||
| increased, Bax expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| decreased, Bcl-2 expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| Increased, glutamate | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased, Bax expression | ||
| Increased, glutamate | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | decreased, Bcl-2 expression | ||
| decreased, Intellectual Quotient | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased, socio-economic burden | ||
| Succinate dehydrogenase, inhibited | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Superoxide generation, increased | ||
| Thyroxine (T4) in serum, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Insulin resistance, increased | ||
| Hippocampal Physiology, Altered | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Activation, Microglia | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neuroinflammation | ||
| Increased, glutamate | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, Microglia | ||
| Systemic acute phase response | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Atherosclerosis | ||
| Increase, Mucin production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Lung function | ||
| Increase, goblet cell number | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mucin production | ||
| Activation, EGFR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, goblet cell number | ||
| Increase, DNA strand breaks | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered Signaling Pathways | ||
| Inhibition of rapid delayed rectifying potassium current | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Prolongation of Action Potential Duration | ||
| hERG channel blockade | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition of rapid delayed rectifying potassium current | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Bone Loss | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Bone Remodeling | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered Bone Cell Homeostasis | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered Bone Cell Homeostasis | ||
| Increase, Bone Remodeling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Bone Loss | ||
| Altered Bone Cell Homeostasis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Bone Remodeling | ||
| Altered Signaling Pathways | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered Bone Cell Homeostasis | ||
| Increase, Cell death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered Bone Cell Homeostasis | ||
| Increase, DNA strand breaks | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Abnormal Neural Remodeling | ||
| Altered Signaling Pathways | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Abnormal Neural Remodeling | ||
| Activation, SCD-1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Synthesis, De Novo Fatty Acid (FA) | ||
| Increase, Pro-Inflammatory Mediators | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Abnormal Neural Remodeling | ||
| Increase, Abnormal Neural Remodeling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Increase, Pro-Inflammatory Mediators | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Abnormal Neural Remodeling | ||
| Tissue resident cell activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Pro-Inflammatory Mediators | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Tissue resident cell activation | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Tissue resident cell activation | ||
| Dysregulation, ACE2 expression and activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, (Micro)vascular dysfunction | ||
| Increase, Reactive Oxygen Species production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Oxidative damage | ||
| Promotion, ovarian adenomas | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Promotion, Ovarian Cancer | ||
| Decrease, androgen receptor activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hypospadias, increased | ||
| Increase, Reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Oxidative Stress | ||
| Decrease, Mitochondrial ATP production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Cardiac contractility | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Mitochondrial ATP production | ||
| Inhibition, Mitochondrial Electron Transport Chain Complexes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Decrease, androgen receptor activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | anogenital distance (AGD), decreased | ||
| Increase, Reactive Oxygen Species production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Nitric Oxide | ||
| Increase, Cell Proliferation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence of Cataracts | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence of Cataracts | ||
| Inadequate DNA repair | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence of Cataracts | ||
| Increased Modified Proteins | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence of Cataracts | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence of Cataracts | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell Proliferation | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oxidative damage to DNA | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Modified Proteins | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, DNA strand breaks | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oxidative damage to DNA | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Modified Proteins | ||
| Synaptic dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Loss of drebrin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Synaptic dysfunction | ||
| Overactivation, NMDARs | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Loss of drebrin | ||
| Decrease, Growth | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Reproductive Success | ||
| Decreased, oxygen binding capacity by hemocyanin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, hemocyanin mRNA | ||
| Increase, pulmonate breathing | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Growth | ||
| Cognitive, sensed as hypoxic/low oxygen environment | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, pulmonate breathing | ||
| increase oxidation of the di-copper moiety of the hemocyanin active site | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cognitive, sensed as hypoxic/low oxygen environment | ||
| Increase, Renal pathology due to VTG deposition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Larval development | ||
| increase oxidation of the di-copper moiety of the hemocyanin active site | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, oxygen binding capacity by hemocyanin | ||
| Increase in reactive oxygen and nitrogen species (RONS) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increase oxidation of the di-copper moiety of the hemocyanin active site | ||
| Increase, Mitochondrial swelling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| Decrease, Coupling of oxidative phosphorylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mitochondrial swelling | ||
| Decrease, Glucose pool | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Cell proliferation | ||
| Increase, Glycolysis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Glucose pool | ||
| Decrease, Coupling of oxidative phosphorylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Glycolysis | ||
| Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, palatal shelf outgrowth | ||
| Cell cycle, disrupted | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Meiotic chromosome dynamics | ||
| Increase, DNA damage | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell cycle, disrupted | ||
| Damaging, Red blood cells; hemolysis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, RBC congestion in liver | ||
| Altered, Nitric Oxide Levels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Endothelial Dysfunction | ||
| Increase, Cell membrane depolarization | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| Decreased Na/K ATPase activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell membrane depolarization | ||
| Decrease, Adenosine triphosphate pool | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased Na/K ATPase activity | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Vascular Remodeling | ||
| Increase, Endothelial Dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Vascular Remodeling | ||
| Status epilepticus | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Intracellular Calcium overload | ||
| Status epilepticus | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, glutamate | ||
| Overactivation, NMDARs | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Status epilepticus | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Endothelial Dysfunction | ||
| Damaging, Red blood cells; hemolysis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Nitric Oxide Levels | ||
| Increased Pro-inflammatory mediators | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Endothelial Dysfunction | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Endothelial Dysfunction | ||
| Altered Signaling Pathways | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Endothelial Dysfunction | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Nitric Oxide Levels | ||
| Altered Signaling Pathways | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Nitric Oxide Levels | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Pro-inflammatory mediators | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered Signaling Pathways | ||
| Damaging, Red blood cells; hemolysis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Liver and splenic hemosiderosis | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Oxidative Stress | ||
| Decrease, Adenosine triphosphate pool | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| Cell injury/death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Growth | ||
| Increase, Cytosolic calcium | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Cardiovascular development/function | ||
| Decrease, Coupling of oxidative phosphorylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cytosolic calcium | ||
| Increased, recruitment of inflammatory cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secretion of proinflammatory mediators | ||
| Increase, Cell death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secretion of proinflammatory mediators | ||
| Production, Reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Peptide Oxidation | ||
| Increase, Incomplete ecdysis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, developmental abnormalities | ||
| Decrease, New cuticle secretion | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Incomplete ecdysis | ||
| Weak, Procuticle protection | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, New cuticle secretion | ||
| Decrease, Prevent chitin degradation by chitinases | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Weak, Procuticle protection | ||
| Decrease, Chitin laminar organization | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Weak, Procuticle protection | ||
| Decrease, knickkopf gene | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Prevent chitin degradation by chitinases | ||
| Decrease, knickkopf gene | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Chitin laminar organization | ||
| Decrease, 20-hydroxyecdysone | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, knickkopf gene | ||
| Increase, Incomplete ecdysis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, hatching of egg | ||
| Increase, Incomplete ecdysis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, delay in oviposition | ||
| Increase, pigmentation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Incomplete ecdysis | ||
| Increase, impairment of cuticle sclerotization | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Incomplete ecdysis | ||
| Increase, Defects in tanning of new cuticle | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, pigmentation | ||
| Increase, Defects in tanning of new cuticle | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, impairment of cuticle sclerotization | ||
| Decrease, dopa decarboxylase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Defects in tanning of new cuticle | ||
| Decrease, Tyrosine | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, dopa decarboxylase | ||
| Increase, developmental abnormalities | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mortality | ||
| Increase, sex ratio (F/M) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, developmental abnormalities | ||
| Increase, Body volume of female adults | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, developmental abnormalities | ||
| Delay, Ovarian maturation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, sex ratio (F/M) | ||
| Delay, Ovarian maturation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Body volume of female adults | ||
| Increase, Vitellogenin mRNA | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Delay, Ovarian maturation | ||
| Increased, Estrogen receptor (ER) activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Vitellogenin mRNA | ||
| Increase, Alcohol dehydrogenase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Estrogen receptor (ER) activity | ||
| Decrease, Smoothend relocation and activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, GLI1/2 translocation to nucleus | ||
| Antagonism, Smoothened receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Smoothend relocation and activation | ||
| Decrease, Sonic Hedgehog second messenger production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Cell proliferation | ||
| Decrease, GLI1/2 target gene expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Sonic Hedgehog second messenger production | ||
| Activation, estrogen receptor alpha | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired, Reproduction | ||
| Increase Chromosomal Aberrations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased microRNA expression | ||
| Increased, DNA damage and mutation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase Chromosomal Aberrations | ||
| Increase, slincR expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Cardiovascular development/function | ||
| Decrease, palatal shelf outgrowth | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Orofacial clefting | ||
| Decrease, Cell proliferation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, palatal shelf outgrowth | ||
| Decrease, GLI1/2 translocation to nucleus | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, GLI1/2 target gene expression | ||
| Increase, RBC congestion in liver | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number | ||
| Activation, PARP1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell death | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial Injury | ||
| Endoplasmic reticulum stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Unfolded Protein Response | ||
| Increased, Intracellular Calcium overload | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Endoplasmic reticulum stress | ||
| Inhibition GABAA receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell membrane depolarization | ||
| Increase, Cell death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Parkinsonian motor deficits | ||
| Activation of calpain signalling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell death | ||
| Increased, Intracellular Calcium overload | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of calpain signalling | ||
| Activation of metabotropic glutamate receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inositol triphosphate receptor activation | ||
| Inositol triphosphate receptor activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Intracellular Calcium overload | ||
| decreased folate uptake | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neural tube defects | ||
| Histone deacetylase inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neural tube defects | ||
| Increased sphingolipid-1-phosphate | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Histone deacetylase inhibition | ||
| Inhibition of Ceramide Synthase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased sphingolipid-1-phosphate | ||
| Affected folate transporter | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | decreased folate uptake | ||
| Reduced complex sphingolipids | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Affected folate transporter | ||
| Inhibition of Ceramide Synthase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced complex sphingolipids | ||
| Decrease, sox9 expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Cardiovascular development/function | ||
| Increase, slincR expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Facial cartilage structures are reduced in size and morphologically distorted | ||
| Alkylation, Protein | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Facial cartilage structures are reduced in size and morphologically distorted | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, sox9 expression | ||
| Facial cartilage structures are reduced in size and morphologically distorted | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Early Life Stage Mortality | ||
| Decrease, sox9 expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Facial cartilage structures are reduced in size and morphologically distorted | ||
| Increase, slincR expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, sox9 expression | ||
| dimerization, AHR/ARNT | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, slincR expression | ||
| Airway remodeling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Chronic obstructive pulmonary disease | ||
| Emphysema | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Chronic obstructive pulmonary disease | ||
| Reduction, Prostaglandin E2 concentration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Gap | ||
| Pulmonary inflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Chronic obstructive pulmonary disease | ||
| Fibroblast proliferation and differentiation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Airway remodeling | ||
| Dysfunctional Autophagy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Emphysema | ||
| Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Emphysema | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Pulmonary inflammation | ||
| Activation of inflammation pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Pulmonary inflammation | ||
| Non-coding RNA expression profile alteration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Dysfunctional Autophagy | ||
| Non-coding RNA expression profile alteration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Apoptosis | ||
| Non-coding RNA expression profile alteration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Fibroblast proliferation and differentiation | ||
| Non-coding RNA expression profile alteration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Oxidative Stress | ||
| Non-coding RNA expression profile alteration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of inflammation pathway | ||
| Activation, estrogen receptor alpha | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Gonadotropins | ||
| Activation, estrogen receptor alpha | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Kisspeptin signalling | ||
| Increase, Cytotoxicity (epithelial cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Secondary genotoxicity | ||
| Substance interaction with the lung resident cell membrane components | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, DNA damage and mutation | ||
| Substance interaction with the lung resident cell membrane components | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reactive oxygen species | ||
| Secondary genotoxicity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, DNA damage and mutation | ||
| Increased, Reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Secondary genotoxicity | ||
| Feminisation or incomplete development, Primary and accessory male sex organs | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Impairment of reproductive capacity | ||
| Increase, Cytotoxicity (epithelial cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reactive oxygen species | ||
| Increased, recruitment of inflammatory cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cytotoxicity (epithelial cells) | ||
| Sensory axonal peripheral neuropathy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Mortality | ||
| Decreased, Neuronal network function in adult brain | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Sensory axonal peripheral neuropathy | ||
| Oxidative Stress in Brain | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Neurodegeneration | ||
| Activation of Cyp2E1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Oxidative Stress in Brain | ||
| Acetylcholinesterase (AchE) Inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of Cyp2E1 | ||
| Increased, fibroblast proliferation and myofibroblast differentiation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Collagen | ||
| Increased, secretion of proinflammatory mediators | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, Dendritic Cells | ||
| Covalent Binding, Protein | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Allergic Respiratory Hypersensitivity Response | ||
| Covalent Binding, Protein | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secretion of proinflammatory mediators | ||
| Occurrence, Kidney toxicity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Kidney Failure | ||
| Occurrence, renal proximal tubular necrosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Kidney toxicity | ||
| Increase in inflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, renal proximal tubular necrosis | ||
| Increase, Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, renal proximal tubular necrosis | ||
| Inhibition, Nuclear factor kappa B (NF-kB) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase in inflammation | ||
| Activation of ER stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Apoptosis | ||
| Altered gene expression, NRF2 dependent antioxidant pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Oxidative Stress | ||
| Altered gene expression, NRF2 dependent antioxidant pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of ER stress | ||
| Inhibition, Mitochondrial Electron Transport Chain Complexes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Mitochondrial membrane potential | ||
| Decreased, Reproductive Success | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Increase, predation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Increased, Oocyte Atresia | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired, Reproduction | ||
| Impaired, Oocyte maturation and ovulation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Oocyte Atresia | ||
| Decreased, Maturation Inducing Steroid Surge by Granulosa cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired, Oocyte maturation and ovulation | ||
| Decreased, Androgen and Progestin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Maturation Inducing Steroid Surge by Granulosa cells | ||
| Decreased, Gonadotropins | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Androgen and Progestin | ||
| Increased, Kisspeptin signalling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Gonadotropins | ||
| Disruption of sodium channel gating kinetics | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Disruption, action potential | ||
| Decreased spermatogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Decreased spermatogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Reproduction | ||
| Increase, DNA damage | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased spermatogenesis | ||
| Decrease, Fecundity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Reproduction | ||
| Decreased spermatogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Fecundity | ||
| Increase, Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased spermatogenesis | ||
| Increased, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Apoptosis | ||
| Increase in reactive oxygen and nitrogen species (RONS) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Oxidative Stress | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase in reactive oxygen and nitrogen species (RONS) | ||
| Epithelial Mesenchymal Transition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | metastatic breast cancer | ||
| Antagonism, Estrogen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Epithelial Mesenchymal Transition | ||
| Increased activation, Nuclear factor kappa B (NF-kB) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Antagonism, Estrogen receptor | ||
| Decreased SIRT1 expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased activation, Nuclear factor kappa B (NF-kB) | ||
| Increased microRNA expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased SIRT1 expression | ||
| Increase, Mutations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased microRNA expression | ||
| Increased, DNA damage and mutation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inadequate DNA repair | ||
| Activation of Tumor Protein 53 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Premature cell differentiation | ||
| Binding to voltage-gated sodium channel | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Disruption of sodium channel gating kinetics | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase risk, microcephaly | ||
| Decreased, PPAR-gamma activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, HSD17B10 expression | ||
| Increase, DNA damage | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of Tumor Protein 53 | ||
| Increased Angiotensin II | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) | ||
| Increase, Oxidative damage to DNA | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oocyte apoptosis | ||
| Increase, Oxidative damage to DNA | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Follicular atresia | ||
| Increase, Reactive Oxygen Species production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oxidative damage to DNA | ||
| Decreased, PPAR-beta activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, HSD17B10 expression | ||
| Increase, DNA strand breaks | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oocyte apoptosis | ||
| Decrease, Oogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Cumulative fecundity and spawning | ||
| Increase, DNA strand breaks | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Follicular atresia | ||
| Increased, circulating estrogen levels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hyperplasia, ovarian epithelium | ||
| Increased, estrogens | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, circulating estrogen levels | ||
| Increased, Steroidogenic acute regulatory protein (StAR) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, estrogens | ||
| Increased, secretion of LH from anterior pituitary | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Steroidogenic acute regulatory protein (StAR) | ||
| Suppression, Estrogen receptor (ER) activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secretion of GnRH from hypothalamus | ||
| Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, tumor growth | ||
| Increased, Migration (Endothelial Cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, angiogenesis | ||
| Increase, Inflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, angiogenesis | ||
| Increase, Inflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Invasion | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Invasion | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Migration (Endothelial Cells) | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Motility | ||
| Decreased, PPAR-alpha activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, HSD17B10 expression | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Apoptosis | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Inflammation | ||
| Inhibition, Mitochondrial Electron Transport Chain Complexes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oxidative Stress | ||
| Neural crest cell migration, reduced | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | transposition of the great arteries | ||
| Disruption, Progenitor cells of second heart field | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neural crest cell migration, reduced | ||
| Decreased, all-trans retinoic acid (atRA) concentration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Disruption, Progenitor cells of second heart field | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Reactive Oxygen Species production | ||
| Decrease, Reproduction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Population trajectory | ||
| Increase, Pollen abnormal | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Reproduction | ||
| Altered, Meiotic chromosome dynamics | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Pollen abnormal | ||
| Increase, Programmed cell death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Reproduction | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, DNA damage | ||
| Decrease, Mitochondrial ATP production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Reproduction | ||
| Increased, Reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Mitochondrial membrane potential | ||
| Reduction, Plasma vitellogenin concentrations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development | ||
| Increased, Reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, D1 protein deactivation | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reactive oxygen species | ||
| Decrease, ATP production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Reproduction | ||
| Increased SARS-CoV-2 production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Intestinal barrier, disruption | ||
| Increased SARS-CoV-2 production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Sustentacular cells, decrease | ||
| Torsades de Pointes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Sudden cardiac death | ||
| Prolongation of QT interval | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Torsades de Pointes | ||
| Prolongation of Action Potential Duration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Prolongation of QT interval | ||
| Increase, Plasma vitellogenin concentrations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Renal pathology due to VTG deposition | ||
| Dysregulation, ACE2 expression and activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Gut microbiota, alteration | ||
| Abnormal, Glucose homeostasis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Gestational diabetes mellitus | ||
| Decrease, Glucose uptake | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Abnormal, Glucose homeostasis | ||
| Decrease, GLUT4 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Glucose uptake | ||
| Increase, TNF | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, GLUT4 | ||
| Increased (ectopic) all-trans retinoic acid concentration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Premature initiation of meiosis in fetal male germ cells | ||
| Increases in cellular reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Porcupine-induced Wnt secretion and Wnt signaling activation | ||
| Reduced size of the ovarian follicle pool | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | irregularities, ovarian cycle | ||
| Reduction, Plasma 17beta-estradiol concentrations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Vitellogenin synthesis in liver | ||
| Accumulation, Cytosolic toxic Tau oligomers | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neuroinflammation | ||
| Impaired axonial transport | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Synaptic dysfunction | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hyperphosphorylation of Tau | ||
| Synaptic dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of neuronal network function | ||
| Accumulation, Cytosolic toxic Tau oligomers | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired axonial transport | ||
| Dysfunctional Autophagy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Cytosolic toxic Tau oligomers | ||
| Decrease of neuronal network function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Memory Loss | ||
| Neuroinflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of neuronal network function | ||
| Alkylation, DNA | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mutations | ||
| Mitochondrial dysfunction EMPTY | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Oxidative Stress | ||
| Increased SARS-CoV-2 production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Viral infection and host-to-host transmission, proliferated | ||
| Interferon-I antiviral response, antagonized by SARS-CoV-2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased SARS-CoV-2 production | ||
| SARS-CoV-2 cell entry | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Interferon-I antiviral response, antagonized by SARS-CoV-2 | ||
| Increased SARS-CoV-2 production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell death | ||
| GSK3beta inactivation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Repression of Gbx2 expression | ||
| Hippocampal Physiology, Altered | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Loss, Cochlear function | ||
| Activation, Pregnane-X receptor, NR1l2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, Upregulation of glucuronyltransferase activity | ||
| Disrupted meiotic initiation of fetal oogonia of the ovary | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced size of the ovarian follicle pool | ||
| Bile accumulation, Pathological condition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of specific nuclear receptors, Transcriptional change | ||
| Increased, Hepatic thyroid hormone uptake/transport | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Clearance of thyroxine from serum | ||
| Induction, Upregulation of glucuronyltransferase activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Clearance of thyroxine from serum | ||
| Decreased, all-trans retinoic acid (atRA) concentration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Disrupted meiotic initiation of fetal oogonia of the ovary | ||
| Inhibition, Iodotyrosine deiodinase (IYD) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Thyroxine (T4) in serum, Decreased | ||
| Thyroxine (T4) in serum, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Cytoplasmic vacuolization (podocyte) | ||
| Thyroxine (T4) in serum, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Cystic dilatation (renal tubule) | ||
| Thyroxine (T4) in serum, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Cytoplasmic vacuolization (Renal tubule) | ||
| altered, inner ear development | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Hearing | ||
| Increase, Cell death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | altered, inner ear development | ||
| Increased, Kidney Failure | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Mortality | ||
| Increase, Necrosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Kidney Failure | ||
| Increased, Lipid peroxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Necrosis | ||
| Increased, Reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Lipid peroxidation | ||
| Oxidation, Glutathione (To be considered with MIE) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reactive oxygen species | ||
| Platelet-neutrophil interactions, Increased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Thromboinflammation, Increased | ||
| Neutrophil activation, Increased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Platelet-neutrophil interactions, Increased | ||
| Platelet activation, Increased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Platelet-neutrophil interactions, Increased | ||
| Release, Cytokine | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neutrophil activation, Increased | ||
| Release, Cytokine | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Platelet activation, Increased | ||
| Endothelial cell dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Release, Cytokine | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cilia Beat Frequency, Decreased | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | FOXJ1 Protein, Decreased | ||
| N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Damaging, Red blood cells; hemolysis | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cystic Fibrosis Transmembrane Regulator Function, Decreased | ||
| Motile Cilia Number/Length, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cilia Beat Frequency, Decreased | ||
| FOXJ1 Protein, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Motile Cilia Number/Length, Decreased | ||
| Mucociliary Clearance, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Lung function | ||
| Cilia Beat Frequency, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mucociliary Clearance, Decreased | ||
| Airway Surface Liquid Height, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cilia Beat Frequency, Decreased | ||
| Cystic Fibrosis Transmembrane Regulator Function, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Airway Surface Liquid Height, Decreased | ||
| N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Propagation, Oxidative stress | ||
| eya1 expression, inhibited | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell death | ||
| six1b expression, increased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | eya1 expression, inhibited | ||
| foxi1 expression, increased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | six1b expression, increased | ||
| Repression of Gbx2 expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | foxi1 expression, increased | ||
| Increase plasma Ang II | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Ang II type 1 receptor (AT1R) | ||
| Induced dysregulation of ACE2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase plasma Ang II | ||
| Prolonged TLR9 activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | NLRP3 inflammasome activity, increased | ||
| Increased activation, Nuclear factor kappa B (NF-kB) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Pro-inflammatory mediators | ||
| Increased activation, Nuclear factor kappa B (NF-kB) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Release, Cytokine | ||
| increased MyD88 activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased activation, Nuclear factor kappa B (NF-kB) | ||
| N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Formation, Formation of hemoglobin adducts | ||
| Prolonged TLR9 activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased MyD88 activation | ||
| Increased, Thyroid-stimulating hormone (TSH) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Hypertrophy and proliferation (follicular cell) | ||
| Thyroxine (T4) in serum, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Thyroid-stimulating hormone (TSH) | ||
| N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered regulation, Alpha hemoglobin | ||
| Increase, Cell Proliferation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, mesotheliomas | ||
| Genomic instability | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell Proliferation | ||
| Increased, DNA damage and mutation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Genomic instability | ||
| Frustrated phagocytosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reactive oxygen species | ||
| Frustrated phagocytosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secretion of proinflammatory mediators | ||
| NLRP3 inflammasome activity, increased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hyperinflammation | ||
| Diminished protective oxidative stress response | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | NLRP3 inflammasome activity, increased | ||
| Increased Cholinergic Signaling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cognitive Function, Decreased | ||
| Decrease of neuronal network function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cognitive Function, Decreased | ||
| Increased Cholinergic Signaling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of neuronal network function | ||
| Propagation, Oxidative stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Damaging, Red blood cells; hemolysis | ||
| increase, placental insufficiency | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increase, Preeclampsia | ||
| abnormal, placental labyrinth vasculature morphology | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increase, placental insufficiency | ||
| reduced production, VEGF | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | abnormal, placental labyrinth vasculature morphology | ||
| Decrease, Cell proliferation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Eye size | ||
| Overexpression of rasl11b | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Cell proliferation | ||
| Inhibition of Plxna2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Overexpression of rasl11b | ||
| Inhibition of Fyna | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition of Plxna2 | ||
| Inhibition of ALDH1A (RALDH) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, all-trans retinoic acid (atRA) concentration | ||
| Increase, Oocyte apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of egg production and cummulative fecundity | ||
| Propagation, Oxidative stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Down Regulation, Gulcose-6-phosphate dehydrogenase | ||
| Alkylation, DNA | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inadequate DNA repair | ||
| Bulky DNA adducts, increase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mutations | ||
| Bulky DNA adducts, increase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inadequate DNA repair | ||
| Deposition of Ionizing Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oocyte apoptosis | ||
| Deposition of Ionizing Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Population size | ||
| Deposition of Ionizing Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of egg production and cummulative fecundity | ||
| Deposition of Ionizing Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Fertility | ||
| Deposition of Ionizing Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased spermatogenesis | ||
| Deposition of Ionizing Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Meiotic chromosome dynamics | ||
| Deposition of Ionizing Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Oxidative Stress | ||
| Decrease of egg production and cummulative fecundity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Population size | ||
| Decreased spermatogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of egg production and cummulative fecundity | ||
| impaired, Fertility | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of egg production and cummulative fecundity | ||
| Increase, Oocyte apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Fertility | ||
| Increased, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oocyte apoptosis | ||
| Altered, Meiotic chromosome dynamics | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased spermatogenesis | ||
| Altered, Meiotic chromosome dynamics | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oocyte apoptosis | ||
| Increase, DNA damage | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oocyte apoptosis | ||
| Increase, DNA damage | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Meiotic chromosome dynamics | ||
| Deposition of Ionizing Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, DNA damage | ||
| Deposition of Ionizing Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reactive oxygen species | ||
| Decreased, Triiodothyronine (T3) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Photoreceptor patterning | ||
| Decreased, Eye size | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Visual function | ||
| Decreased, Triiodothyronine (T3) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Eye size | ||
| Altered, Visual function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Mortality | ||
| Altered, retinal layer structure | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Visual function | ||
| Decreased, Triiodothyronine (T3) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, retinal layer structure | ||
| Loss of alveolar capillary membrane integrity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Lung function | ||
| Alveolar collapse | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Lung function | ||
| Inhibition of lung surfactant function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Lung function | ||
| Loss of alveolar capillary membrane integrity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced tidal volume | ||
| Loss of alveolar capillary membrane integrity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition of lung surfactant function | ||
| Reduced tidal volume | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Lung function | ||
| olfactory sensory neurons, decrease | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired olfactory function (anosmia) | ||
| Sustentacular cells, decrease | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired olfactory function (anosmia) | ||
| Olfactory epithelium degeneration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired olfactory function (anosmia) | ||
| olfactory sensory neurons, decrease | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Olfactory epithelium degeneration | ||
| Sustentacular cells, decrease | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | olfactory sensory neurons, decrease | ||
| Coagulation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Diminished protective oxidative stress response | ||
| Diminished protective oxidative stress response | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Coagulation | ||
| Increased SARS-CoV-2 production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Diminished protective oxidative stress response | ||
| Bradykinin system, hyperactivated | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hyperinflammation | ||
| Fibrinolysis, decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secretion of proinflammatory mediators | ||
| Bradykinin system, hyperactivated | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Fibrinolysis, decreased | ||
| Increased, recruitment of inflammatory cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hyperinflammation | ||
| Bradykinin system, hyperactivated | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secretion of proinflammatory mediators | ||
| Fibrinolysis, decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Bradykinin system, hyperactivated | ||
| Increased SARS-CoV-2 production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Toll Like Receptor (TLR) Dysregulation | ||
| Inhibition, Aromatase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Male Biased Sex Ratio | ||
| Agonism, Androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Male Biased Sex Ratio | ||
| Decrease, ATP production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Leaf development | ||
| Increase, Oxygen-evolving complex damage | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Photosystem II efficiency | ||
| Increase, DNA damage | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Programmed cell death | ||
| Decrease, Reproduction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Decrease, Leaf development | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Reproduction | ||
| Decrease, Photosynthesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, ATP production | ||
| Decrease, Photosystem II efficiency | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Photosynthesis | ||
| Increased Sodium-sensitive hypertension | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Chronic kidney disease | ||
| Increased, Reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Sodium-sensitive hypertension | ||
| Increased Angiotensin II | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Ang II type 1 receptor (AT1R) | ||
| Hyperactivation of ACE/Ang-II/AT1R axis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Angiotensin II | ||
| Increased, extracellular matrix deposition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Liver fibrosis | ||
| Increased, Reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, extracellular matrix deposition | ||
| Increased Ang II type 1 receptor (AT1R) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reactive oxygen species | ||
| Increased, Reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased activation, Nuclear factor kappa B (NF-kB) | ||
| Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reactive oxygen species | ||
| Imbalanced salty and sweet taste responses | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired gustatory nerve | ||
| Increased Angiotensin II | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Imbalanced salty and sweet taste responses | ||
| Binding to ACE2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Downregulation, ACE2 | ||
| Binding to ACE2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Dysregulation, ACE2 expression and activity | ||
| SARS-CoV-2 cell entry | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased SARS-CoV-2 production | ||
| Increased activation, Nuclear factor kappa B (NF-kB) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secretion of proinflammatory mediators | ||
| Increased, secretion of proinflammatory mediators | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Collagen | ||
| Toll Like Receptor (TLR) Dysregulation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secretion of proinflammatory mediators | ||
| Alkylation, DNA | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Heritable mutations in offspring | ||
| Impaired gustatory nerve | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | dysgeusia | ||
| decreased oocyte maturation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Fertility | ||
| impaired, Fertility | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Coagulation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Thrombosis and Disseminated Intravascular Coagulation | ||
| Binding of antagonist, NMDA receptors | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, NMDARs | ||
| Neuroinflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Encephalitis | ||
| N/A, Neurodegeneration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Encephalitis | ||
| Binding to ACE2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neuroinflammation | ||
| Alveolar collapse | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Loss of alveolar capillary membrane integrity | ||
| Decrease, Leaf development | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Growth | ||
| Decreased plasma Cortisol level | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | decreased oocyte maturation | ||
| Cortisol and 11β-(OH) testosterone decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, plasma 11-ketotestosterone level | ||
| Cortisol and 11β-(OH) testosterone decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased plasma Cortisol level | ||
| 11β-hydroxylase inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cortisol and 11β-(OH) testosterone decreased | ||
| Impaired, Spermatogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Fertility | ||
| Altered, Transcription of genes by the androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Granulosa cell proliferation of gonadotropin-independent follicles, Reduced | ||
| Increased, Free serum thyroxine (T4) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Clearance of thyroxine from serum | ||
| Increased, Clearance of thyroxine from serum | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Thyroxine (T4) in serum, Decreased | ||
| Decrease, Acyl-CoA dehydrogenases | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Mitochondrial Fatty Acid Beta Oxidation | ||
| Activation, Glucocorticoid Receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Acyl-CoA dehydrogenases | ||
| Accumulation, Triglyceride | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Liver Steatosis | ||
| Decreased, Mitochondrial Fatty Acid Beta Oxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Triglyceride | ||
| Agonism, Androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Differentiation to Testis | ||
| Increase, cell proliferation (hepatocytes) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, hepatocellular adenomas and carcinomas | ||
| Activation, PPARα | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, hepatocellular adenomas and carcinomas | ||
| Activation, PPARα | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, cell proliferation (hepatocytes) | ||
| Binding, Thyroid binding globulin in serum | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Displacement, Serum thyroxine (T4) from carrier protein | ||
| Displacement, Serum thyroxine (T4) from carrier protein | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Free serum thyroxine (T4) | ||
| Binding, Transthyretin in serum | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Displacement, Serum thyroxine (T4) from carrier protein | ||
| Increased, Free serum thyroxine (T4) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Hepatic thyroid hormone uptake/transport | ||
| Displacement, Serum thyroxine (T4) from transthyretin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Free serum thyroxine (T4) | ||
| Binding, Transthyretin in serum | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Displacement, Serum thyroxine (T4) from transthyretin | ||
| Altered, Thyroid hormone-dependent gene expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Amphibian metamorphosis | ||
| Increased, Triiodothyronine (T3) in tissues | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Thyroid hormone-dependent gene expression | ||
| Increased, Thyroxine (T4) in serum | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Thyroid hormone-dependent gene expression | ||
| Increased, Thyroxine (T4) in serum | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Amphibian metamorphosis | ||
| Increased, Thyroid-stimulating hormone (TSH) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Thyroxine (T4) in serum | ||
| Decreased, Triiodothyronine (T3) in tissues | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Thyroid hormone-dependent gene expression | ||
| Decreased, Triiodothyronine (T3) in tissues | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Thyroid-stimulating hormone (TSH) | ||
| Increased, Hepatic thyroid hormone uptake/transport | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Thyroxine (T4) in serum, Decreased | ||
| Inhibition, Na+/I- symporter (NIS) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Thyroxine (T4) in serum, Decreased | ||
| Reduced, Hearing | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Mortality | ||
| Increase, Mitochondrial complex III antagonism | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Adenosine triphosphate pool | ||
| Increase, Mitochondrial ATP synthase antagonism | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Adenosine triphosphate pool | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Adenosine triphosphate pool | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Reactive oxygen species | ||
| Increase, Global DNA methylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Apoptosis | ||
| Increase, Reactive Oxygen Species production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Global DNA methylation | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Reactive Oxygen Species production | ||
| Increase, Cell death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Growth | ||
| Decrease, Adenosine triphosphate pool | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell death | ||
| Reduced, Posterior swim bladder inflation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Mortality | ||
| Reduced, Swimming performance | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Mortality | ||
| Decrease, Adenosine triphosphate pool | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Oogenesis | ||
| Decrease, Cell proliferation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Growth | ||
| Decrease, Adenosine triphosphate pool | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Cell proliferation | ||
| Decrease, Coupling of oxidative phosphorylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Adenosine triphosphate pool | ||
| Activation of ER stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Apoptotic cell death | ||
| Increase in inflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Immune mediated hepatitis | ||
| Apoptotic cell death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase in inflammation | ||
| IFNγ signaling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase in inflammation | ||
| Immune cell activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | IFNγ signaling | ||
| benzoquinone imine and acylglucuronide metabolites | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Immune cell activation | ||
| Inhibition, Chitobiase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Digestion of old cuticle | ||
| Decrease, Digestion of old cuticle | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Premature molting | ||
| Inhibition, Chitinase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Digestion of old cuticle | ||
| Thyroxine (T4) in serum, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Amphibian metamorphosis | ||
| Inhibition, Aromatase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Differentiation to Testis | ||
| Decreased, plasma 11-ketotestosterone level | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased spermatogenesis | ||
| Inhibition of 11β-HSD | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, plasma 11-ketotestosterone level | ||
| Decreased spermatogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Fertility | ||
| Activator protein 1 activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Latent Transforming growth Factor beta expression | ||
| Inactivation of PPARγ | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, TGF-beta pathway | ||
| Epithelial Mesenchymal Transition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Pulmonary fibrosis | ||
| Activation, TGF-beta pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Epithelial Mesenchymal Transition | ||
| Latent Transforming growth Factor beta expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, TGF-beta pathway | ||
| Pin-1 activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Latent Transforming growth Factor beta expression | ||
| Activation, JNK | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Pin-1 activation | ||
| Activation, JNK | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activator protein 1 activation | ||
| Toll-like receptor 4 activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, JNK | ||
| Increased, Male Biased Sex Ratio | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Increased, Differentiation to Testis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Male Biased Sex Ratio | ||
| Reduction, 17beta-estradiol synthesis by the undifferentiated gonad | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Differentiation to Testis | ||
| Inhibition, Aromatase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, 17beta-estradiol synthesis by the undifferentiated gonad | ||
| Altered, Visual function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Accumulation, Collagen | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Lung fibrosis | ||
| Downregulation, ACE2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Angiotensin II | ||
| Increase, the risk of acute respiratory failure | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Mortality | ||
| Antagonism, Androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Nipple retention (NR), increased | ||
| Altered, Transcription of genes by the androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Nipple retention (NR), increased | ||
| Decrease, testosterone levels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, androgen receptor activation | ||
| Antagonism, Androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, androgen receptor activation | ||
| Inhibition, NMDARs | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Calcium influx | ||
| decrease, transcription of genes by AR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | anogenital distance (AGD), decreased | ||
| Decrease, androgen receptor activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | decrease, transcription of genes by AR | ||
| Altered, Transcription of genes by the androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | anogenital distance (AGD), decreased | ||
| Decrease, testosterone levels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, dihydrotestosterone (DHT) level | ||
| Reduction, Testosterone synthesis in Leydig cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, testosterone levels | ||
| Decrease, androgen receptor activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Transcription of genes by the androgen receptor | ||
| Antagonism, Androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | anogenital distance (AGD), decreased | ||
| Decreased, Nitric Oxide | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Long-term potentiation (LTP) | ||
| Increase, Ovarian follicle breakdown (F3) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Oogenesis (F3) | ||
| Increase, Ovarian somatic cell apoptosis (F3) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Ovarian follicle breakdown (F3) | ||
| Increase, Caspase transcription (F3) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Ovarian somatic cell apoptosis (F3) | ||
| Decrease, Fecundity (F3) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Decrease, Oogenesis (F3) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Fecundity (F3) | ||
| Increase, Oocyte apoptosis (F3) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Oogenesis (F3) | ||
| Increase, Caspase transcription (F3) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oocyte apoptosis (F3) | ||
| Decrease, Heritable DNA methylation (F3) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Caspase transcription (F3) | ||
| Decrease, Global DNA methylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Heritable DNA methylation (F3) | ||
| Increase, Ovarian follicle breakdown | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Oogenesis | ||
| Increase, Ovarian somatic cell apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Ovarian follicle breakdown | ||
| Increase, Caspase transcription | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Ovarian somatic cell apoptosis | ||
| Increase, Oocyte apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Oogenesis | ||
| Increase, Caspase transcription | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oocyte apoptosis | ||
| Decrease, Global DNA methylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Caspase transcription | ||
| Increase, DNA methyltransferase inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Global DNA methylation | ||
| Increase, Reactive Oxygen Species production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oxidative DNA damage | ||
| Decrease, Neutral lipids | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Adenosine triphosphate pool | ||
| Increased, Lipid peroxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Neutral lipids | ||
| Decrease, Adenosine triphosphate pool | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mortality | ||
| Decrease, Oxidative phosphorylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Adenosine triphosphate pool | ||
| Decrease, Mitochondrial membrane potential | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Oxidative phosphorylation | ||
| Increase, Reactive Oxygen Species production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Mitochondrial membrane potential | ||
| Increase, Body fluid overload | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mortality | ||
| Increase, Abnormal osmoregulation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Body fluid overload | ||
| Increase, Protein oxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Abnormal osmoregulation | ||
| Increase, Reactive Oxygen Species production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Protein oxidation | ||
| Increase, Hyperplasia (urothelial) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Urothelial Tumor | ||
| Urothelial cell injury/death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Regenerative cell proliferation (urothelial cells) | ||
| Increase, Cripto-1 expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, Fin regeneration | ||
| Reduced, Swimming performance | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Inhibition, Fin regeneration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Swimming performance | ||
| Neuroinflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Neurodegeneration | ||
| Inhibition, Activin signaling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, Fin regeneration | ||
| Increase, Cripto-1 expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, Activin signaling | ||
| Activation, Glucocorticoid Receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cripto-1 expression | ||
| Decreased, plasma 11-ketotestosterone level | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired, Spermatogenesis | ||
| Increase, Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduce, Sperm count | ||
| Increase, DNA strand breaks | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Apoptosis | ||
| Activation, PPARα | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, cholesterol | ||
| Decreased, cholesterol | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, plasma 11-ketotestosterone level | ||
| Porcupine-induced Wnt secretion and Wnt signaling activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | beta-catenin activation | ||
| N/A, Neurodegeneration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neuroinflammation | ||
| Chronic reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Porcupine-induced Wnt secretion and Wnt signaling activation | ||
| Induced dysregulation of ACE2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Angiotensin II | ||
| Increased inflammatory immune responses | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, the risk of acute respiratory failure | ||
| Increased, secretion of proinflammatory mediators | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased inflammatory immune responses | ||
| Binding to ACE2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | SARS-CoV-2 cell entry | ||
| Increased, secretion of proinflammatory mediators | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Transcription of genes encoding acute phase proteins, Increased | ||
| Thyroxine (T4) in serum, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Triiodothyronine (T3) | ||
| Acinar cell proliferation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Pancreatic acinar cell tumors | ||
| Increased exocrine secretion from pancreatic acinar cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Acinar cell proliferation | ||
| Increased blood CCK level | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased exocrine secretion from pancreatic acinar cells | ||
| Altered, Neuroanatomy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Neurophysiology | ||
| Increased intestinal monitor peptide level | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased blood CCK level | ||
| Trypsin inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased intestinal monitor peptide level | ||
| Suppression of IL-4 production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment of T-cell dependent antibody response | ||
| Suppression of STAT5 binding to cytokine gene promoters | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Suppression of IL-4 production | ||
| Blockade of STAT5 phosphorylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Suppression of STAT5 binding to cytokine gene promoters | ||
| Inhibition of JAK3 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Blockade of STAT5 phosphorylation | ||
| Increase of anti-DNA antibody from autoreactive B cell | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Exacerbation of systemic lupus erythematosus (SLE) | ||
| Increase of Th2 cells producing IL-4 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase of anti-DNA antibody from autoreactive B cell | ||
| Induction of GATA3 expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase of Th2 cells producing IL-4 | ||
| Binding to estrogen receptor (ER)-α in immune cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction of GATA3 expression | ||
| Increase, Mutations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Heritable mutations in offspring | ||
| Th17 cell migration and inflammation induction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Psoriatic skin disease | ||
| Increase, IL-23 from matured dendritic cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Th17 cell migration and inflammation induction | ||
| Stimulation, TLR7/8 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, IL-23 from matured dendritic cells | ||
| Acetylcholinesterase (AchE) Inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Impaired coordination and movement | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Acetylcholinesterase (AchE) Inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired coordination and movement | ||
| Increased Mortality | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Impaired coordination and movement | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Mortality | ||
| Increased Cholinergic Signaling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired coordination and movement | ||
| Histone deacetylase inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Spermatocyte depletion | ||
| Increased, Reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Oxidative Stress | ||
| Acetylcholinesterase (AchE) Inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Dysregulation of heart rate and vascular tone | ||
| Dysregulation of heart rate and vascular tone | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Respiratory distress/arrest | ||
| Increased Cholinergic Signaling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Dysregulation of heart rate and vascular tone | ||
| Inhibition, Nuclear factor kappa B (NF-kB) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Suppression of T cell activation | ||
| Impaired IL-1R1 signaling in T cell | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, Nuclear factor kappa B (NF-kB) | ||
| Histone acetylation, increase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell cycle, disrupted | ||
| dimerization, AHR/ARNT | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, DNA methyltransferase expression | ||
| Decrease, expression of gonadotropin releasing hormone receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | ||
| Increase, hypermethylation of the promotor region of gonadotropin releasing hormone receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, expression of gonadotropin releasing hormone receptor | ||
| Increase, DNA methyltransferase expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, hypermethylation of the promotor region of gonadotropin releasing hormone receptor | ||
| Decrease of egg production and cummulative fecundity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decline, Population trajectory | ||
| Impaired ovulation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of egg production and cummulative fecundity | ||
| Reduction, progesterone uptake, decresed maturation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired ovulation | ||
| Reduction, Plasma progesterone concentration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, progesterone uptake, decresed maturation | ||
| Reduction, Progesterone synthesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Plasma progesterone concentration | ||
| Antagonism,LH receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Progesterone synthesis | ||
| Increase, Chromosomal aberrations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, lung cancer | ||
| Increase, Mutations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, lung cancer | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, lung cancer | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Chromosomal aberrations | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mutations | ||
| Increase, Cell Proliferation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, lung cancer | ||
| Increase, Chromosomal aberrations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell Proliferation | ||
| Increase, Mutations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell Proliferation | ||
| Deposition of Energy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, DNA strand breaks | ||
| Alveolar collapse | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced tidal volume | ||
| Inhibition of lung surfactant function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Alveolar collapse | ||
| Increase, Cell Proliferation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Lung cancer | ||
| Increased, DNA damage and mutation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell Proliferation | ||
| Increased, Reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, DNA damage and mutation | ||
| Increased, recruitment of inflammatory cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reactive oxygen species | ||
| Release, Cytokine | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, recruitment of inflammatory cells | ||
| Frustrated phagocytosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Release, Cytokine | ||
| Induced, dysfunction of microcirculation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired,anterior-posterior axis development | ||
| Increased, Plasma HCY level | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induced, dysfunction of microcirculation | ||
| Increased Homocysteine level | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Plasma HCY level | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased reactive oxygen species (in the mitochondria) | ||
| Increased reactive oxygen species (in the mitochondria) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Decrease in mitochondrial oxidative phosphorylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial dysfunction | ||
| Inhibition of cystathionine beta-synthase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Homocysteine level | ||
| Antagonism, Thyroid Receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cognitive Function, Decreased | ||
| Antagonism, Thyroid Receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hippocampal gene expression, Altered | ||
| Binding of inhibitor to mitochondrial complex V | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial Complex V inhibition | ||
| Binding of inhibitor to mitochondrial complex IV | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Mitochondrial Complex IV inhibition | ||
| Binding of inhibitor to mitochondrial complex III | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mitochondrial complex III antagonism | ||
| Impaired, Proteostasis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| Inhibition, NADH-ubiquinone oxidoreductase (complex I) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease in mitochondrial oxidative phosphorylation | ||
| Increase, DNA strand breaks | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Chromosomal aberrations | ||
| Impaired inguinoscrotal testicular descent phase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Malformation, cryptorchidism - maldescended testis | ||
| Decrease, androgen receptor activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired inguinoscrotal testicular descent phase | ||
| Decrease, testosterone synthesis/level | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, androgen receptor activation | ||
| Decrease, dihydrotestosterone (DHT) level | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, androgen receptor activation | ||
| Decrease, testosterone synthesis/level | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, dihydrotestosterone (DHT) level | ||
| Reduction, 17-OH-progesterone conversion in androstenedione | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, testosterone synthesis/level | ||
| Reduction, 17-OH-pregnenolone conversion in DHEA | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, testosterone synthesis/level | ||
| Increase, DNA strand breaks | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mutations | ||
| Altered, Photoreceptor patterning | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Visual function | ||
| Decreased plasma RA level | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Photoreceptor patterning | ||
| Decreased retinoic acid (RA) synthesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased plasma RA level | ||
| Retinaldehyde dehydrogenase inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased retinoic acid (RA) synthesis | ||
| Increase, Oxidative damage to DNA | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mutations | ||
| Increase, Oxidative damage to DNA | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, DNA strand breaks | ||
| Inadequate DNA repair | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Chromosomal aberrations | ||
| Increase, DNA strand breaks | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inadequate DNA repair | ||
| Inadequate DNA repair | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, DNA strand breaks | ||
| Increase, Oxidative damage to DNA | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inadequate DNA repair | ||
| Increased Pro-inflammatory mediators | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell Proliferation (Epithelial Cells) | ||
| Increase, Cell Proliferation (Epithelial Cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mutations | ||
| Increase in reactive oxygen and nitrogen species (RONS) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Tissue resident cell activation | ||
| Leukocyte recruitment/activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase in reactive oxygen and nitrogen species (RONS) | ||
| Increase in reactive oxygen and nitrogen species (RONS) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, DNA damage | ||
| Increased Pro-inflammatory mediators | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase in reactive oxygen and nitrogen species (RONS) | ||
| Increased Pro-inflammatory mediators | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Breast Cancer | ||
| Decreased, Mitochondrial fatty acid beta-oxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Fatty acid | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Up Regulation, CYP1A1 | ||
| Increase, DNA damage | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Tissue resident cell activation | ||
| Increase, DNA damage | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mutations | ||
| Increase, Mutations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell Proliferation (Epithelial Cells) | ||
| Reduction fo Pigmentation pattern | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Reduction of melanosome level | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction fo Pigmentation pattern | ||
| Reduction in melanin level | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction of melanosome level | ||
| Reduction of L-Dopaquinone | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction in melanin level | ||
| Inhibition of tyrosinase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction of L-Dopaquinone | ||
| Occurrence, Focal Seizure | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, glutamate | ||
| Disruption, Mitochondrial electron transport chain | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Reactive Oxygen Species production | ||
| Activation, Muscarinic Acetylcholine Receptors | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Focal Seizure | ||
| Decrease, Fecundity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Population growth rate | ||
| Decrease, dihydrotestosterone (DHT) level | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Plasma 17beta-estradiol concentrations | ||
| Inhibition, 5α-reductase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, dihydrotestosterone (DHT) level | ||
| Disruption, Mitochondrial electron transport chain | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Mitochondrial ATP production | ||
| Inhibition, Cytochrome P450 enzyme (CYP17A1) activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, 17-OH-progesterone conversion in androstenedione | ||
| Inhibition, Cytochrome P450 enzyme (CYP17A1) activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, 17-OH-pregnenolone conversion in DHEA | ||
| Increase, Oxidative DNA damage | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Apoptosis | ||
| Increase, Reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oxidative DNA damage | ||
| Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Liver Injury | ||
| Activation of hepatic stellate cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Liver Injury | ||
| Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of hepatic stellate cells | ||
| Unfolded Protein Response | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Apoptosis | ||
| Accumulation of misfolded proteins | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Unfolded Protein Response | ||
| Inhibition of N-linked glycosylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation of misfolded proteins | ||
| Increased, Intracellular Calcium overload | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| Increased, glutamate | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Overactivation, NMDARs | ||
| Acetylcholine accumulation in synapses | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, Muscarinic Acetylcholine Receptors | ||
| Oxidation/denatuation of membrane proteins | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inflamatory events in light-exposed tissues | ||
| Oxidation of membrane lipids | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inflamatory events in light-exposed tissues | ||
| ROS generation from photoactivated chemicals | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Oxidation/denatuation of membrane proteins | ||
| ROS generation from photoactivated chemicals | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Oxidation of membrane lipids | ||
| Fibroproliferative airway lesions | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Bronchiolitis obliterans | ||
| Epithelial Mesenchymal Transition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Fibroproliferative airway lesions | ||
| Increase, Inflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Fibroproliferative airway lesions | ||
| Airway epithelial injury | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Inflammation | ||
| Proteasomal dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Airway epithelial injury | ||
| Interaction of α-diketones with arginine residues | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Proteasomal dysfunction | ||
| Impaired axonial transport | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Sensory axonal peripheral neuropathy | ||
| Disturbance in microtubule dynamic instability | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired axonial transport | ||
| Binding of microtubule stabilizing agents (MSA) to microtubules | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Disturbance in microtubule dynamic instability | ||
| Activation, Tissue resident cells (Kuppfer cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, proinflammatory mediators (TNFalpha) | ||
| Cell injury/death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, Tissue resident cells (Kuppfer cells) | ||
| Cell injury/death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Necrotic Tissue | ||
| Activation, Caspase 8 pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| Inhibition, Nuclear factor kappa B (NF-kB) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, Caspase 8 pathway | ||
| Inhibition, IKK complex | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, Nuclear factor kappa B (NF-kB) | ||
| N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Cyanosis occurs | ||
| Decreased proximal tubular vectorial transport | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Chemical induced Fanconi syndrome | ||
| Decreased Na/K ATPase activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased proximal tubular vectorial transport | ||
| Decrease, Oxidative phosphorylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased Na/K ATPase activity | ||
| Inhibition, NADH-ubiquinone oxidoreductase (complex I) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Oxidative phosphorylation | ||
| Altered differentiation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neural tube defects | ||
| Altered, Gene Expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered differentiation | ||
| Histone acetylation, increase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Gene Expression | ||
| Histone deacetylase inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Collagen production, reduced | ||
| Collagen production, reduced | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Facial cartilage structures are reduced in size and morphologically distorted | ||
| Neural crest cell migration, reduced | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Collagen production, reduced | ||
| Histone deacetylase inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neural crest cell migration, reduced | ||
| Necrotic Tissue | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Liver Injury | ||
| Mitochondrial Complex V inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease in mitochondrial oxidative phosphorylation | ||
| Mitochondrial Complex IV inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease in mitochondrial oxidative phosphorylation | ||
| Increase, Mitochondrial complex III antagonism | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease in mitochondrial oxidative phosphorylation | ||
| Epithelial Mesenchymal Transition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Collagen Deposition | ||
| Leukocyte recruitment/activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, Stellate cells | ||
| Increased Pro-inflammatory mediators | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Leukocyte recruitment/activation | ||
| Cell injury/death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Pro-inflammatory mediators | ||
| Endocytotic lysosomal uptake | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Disruption, Lysosome | ||
| Increased neurokinin A (NKA) by neuronal cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Respiratory irritability and Chronic Cough, | ||
| SP (Substance P) release, Local increase of SP | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Respiratory irritability and Chronic Cough, | ||
| Increased Respiratory irritability and Chronic Cough, | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea | ||
| Activation, LXR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, SREBP-1c | ||
| Reduction, Plasma vitellogenin concentrations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Cumulative fecundity and spawning | ||
| Thyroid hormone synthesis, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Plasma 17beta-estradiol concentrations | ||
| Decreased protection against oxidative stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Oxidative Stress | ||
| Binding, Thiol/seleno-proteins involved in protection against oxidative stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased protection against oxidative stress | ||
| Increased Pro-inflammatory mediators | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, Stellate cells | ||
| Tissue resident cell activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Pro-inflammatory mediators | ||
| Disruption, Sarcomere assembly | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Cardiac contractility | ||
| Disruption, Intracellular calcium mobilization | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Disruption, Sarcomere assembly | ||
| Decrease, Calcium currents | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Disruption, Intracellular calcium mobilization | ||
| Activation, LXR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, SCD-1 | ||
| Decrease, Cardiac ejection fraction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Heart failure | ||
| Decrease, Cardiac contractility | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Cardiac ejection fraction | ||
| Decrease, Calcium binding to Troponin C | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Cardiac contractility | ||
| Decrease, Calcium currents | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Calcium binding to Troponin C | ||
| Blockade, L-Type Calcium Channels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Calcium currents | ||
| Decrease, Oogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Fecundity | ||
| Increase, Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mortality | ||
| Activation, LXR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, FAS | ||
| Fatty Acid Beta Oxidation, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Ketogenesis (production of ketone bodies) | ||
| Decreased, PPARalpha transactivation of gene expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Fatty Acid Beta Oxidation, Decreased | ||
| Increase, Opening of voltage-dependent calcium channel | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Cuticular chitin content | ||
| Increase, Cell membrane depolarization | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Opening of voltage-dependent calcium channel | ||
| Increase, Sulfonylurea receptor binding | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell membrane depolarization | ||
| Increase, Premature molting | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mortality | ||
| Decrease, Cuticular chitin content | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Premature molting | ||
| Inhibition, Chitin synthase 1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Cuticular chitin content | ||
| Activation, LXR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, ChREBP | ||
| Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Spermatocyte depletion | ||
| Spermatocyte depletion | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Testicular atrophy | ||
| General Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Neurodegeneration | ||
| Unfolded Protein Response | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | General Apoptosis | ||
| Lipid Peroxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | General Apoptosis | ||
| Oxidative Stress in Brain | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Unfolded Protein Response | ||
| Activation, LXR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Up Regulation, CD36 | ||
| Protein Adduct Formation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Unfolded Protein Response | ||
| Lipid Peroxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Protein Adduct Formation | ||
| Oxidative Stress in Brain | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Lipid Peroxidation | ||
| CYP2E1 Activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Oxidative Stress in Brain | ||
| Increase, Inflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Epithelial Mesenchymal Transition | ||
| Activation of TGF-β signaling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Inflammation | ||
| Activation, Long term AHR receptor driven direct and indirect gene expression changes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects | ||
| Increased Pro-inflammatory mediators | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| Cell injury/death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Tissue resident cell activation | ||
| Histone deacetylase inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Testicular atrophy | ||
| Histone deacetylase inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Apoptosis | ||
| Histone deacetylase inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell cycle, disrupted | ||
| Cell cycle, disrupted | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Apoptosis | ||
| Histone deacetylase inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Histone acetylation, increase | ||
| Increased, activation of T (T) helper (h) type 2 cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, fibroblast proliferation and myofibroblast differentiation | ||
| Loss of alveolar capillary membrane integrity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, activation of T (T) helper (h) type 2 cells | ||
| Increased, recruitment of inflammatory cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Loss of alveolar capillary membrane integrity | ||
| Increased, secretion of proinflammatory mediators | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, recruitment of inflammatory cells | ||
| Substance interaction with the lung resident cell membrane components | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secretion of proinflammatory mediators | ||
| Activation/Proliferation, T-cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Allergic Respiratory Hypersensitivity Response | ||
| Induction, Liver “Dysfunctional” Changes by CGA 330050 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 | ||
| Peptide Oxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | KE1 : S-Glutathionylation, eNOS | ||
| Increased, Oncotic Necrosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Steatohepatisis | ||
| Increased, Reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Oncotic Necrosis | ||
| Increased, Liver Steatosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reactive oxygen species | ||
| Increase, cytosolic fatty acid | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Liver Steatosis | ||
| Inhibition, Fatty Acid Beta Oxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, cytosolic fatty acid | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| Increase, Liver and splenic hemosiderosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number | ||
| Cell injury/death | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of neuronal network function | ||
| Neuroinflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| Glutamate dyshomeostasis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Cell injury/death | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Glutamate dyshomeostasis | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Oxidative Stress | ||
| Decrease, Mitochondrial ATP production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cytotoxicity (renal tubular cell) | ||
| Disruption, Lysosome | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cytotoxicity (renal tubular cell) | ||
| Disturbance, Lysosomal function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Disruption, Lysosome | ||
| Binding of substrate, endocytic receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Disturbance, Lysosomal function | ||
| Increase, Cytotoxicity (renal tubular cell) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, Kidney toxicity | ||
| Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Depletion, mtDNA | ||
| Decrease, Leaf cell mitosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Leaf development | ||
| Decrease, Mitochondrial ATP production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Leaf cell mitosis | ||
| Decrease, Oxidative phosphorylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Mitochondrial ATP production | ||
| Decrease, Glycolysis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Oxidative phosphorylation | ||
| Decrease, Photosynthesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Glycolysis | ||
| Decrease, Light harvest capacity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Photosynthesis | ||
| Decrease, Chlorophyll synthesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Light harvest capacity | ||
| Decrease, ATP production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Chlorophyll synthesis | ||
| Increase, Uncoupling of photophosphorylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, ATP production | ||
| Activation, SREBF1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Liver Steatosis | ||
| Activation, AKT2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, SREBF1 | ||
| Decreased, Ketogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Fatty acid | ||
| peroxisome proliferator activated receptor promoter demethylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, FA Influx | ||
| Increased, FA Influx | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Triglyceride formation | ||
| Up Regulation, SCD-1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Triglyceride | ||
| Activation, AhR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Up Regulation, SCD-1 | ||
| Epithelial Mesenchymal Transition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Collagen | ||
| Increase, Differentiation of fibroblasts | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Collagen | ||
| Activation, Transforming Growth Factor beta pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Epithelial Mesenchymal Transition | ||
| Activation, Transforming Growth Factor beta pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Differentiation of fibroblasts | ||
| Activation, Latent Transforming Growth Factor Beta 1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, Transforming Growth Factor beta pathway | ||
| Decreased sperm quantity or quality in the adult, Decreased fertility | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Fertility | ||
| Reduction, fetal/adult testosterone | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased sperm quantity or quality in the adult, Decreased fertility | ||
| Repressed expression of steroidogenic enzymes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Testosterone synthesis in Leydig cells | ||
| Increased apoptosis, decreased fetal/adult Leydig Cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Testosterone synthesis in Leydig cells | ||
| Glucocorticoid Receptor Agonist, Activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Repressed expression of steroidogenic enzymes | ||
| Glucocorticoid Receptor Agonist, Activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased apoptosis, decreased fetal/adult Leydig Cells | ||
| Impairment, Learning and memory | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, locomotion | ||
| Decrease, histaminergic neuron excitation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Reduced, Swimming performance | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, survival | ||
| Reduced, Swimming performance | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Growth, reduction | ||
| Notochord distortion or malformations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Swimming performance | ||
| Inadequate DNA repair | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mutations | ||
| Weak collagen matrix | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Notochord distortion or malformations | ||
| Reduction of collagen crosslinking | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Weak collagen matrix | ||
| Inhibition of lysyl oxidase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction of collagen crosslinking | ||
| Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition of lysyl oxidase | ||
| Increase, DNA double-strand breaks | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | MLL chromosomal translocation | ||
| Binding to (interferes with) topoisomerase II enzyme | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, DNA double-strand breaks | ||
| Accumulation, Collagen | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Pulmonary fibrosis | ||
| decreased methylation of dopamine transporter promoter | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | decreased dopamine | ||
| decreased DNA methylation of tyrosine hydroxylase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | decreased dopamine | ||
| decreased methylation of dopamine transporter promoter | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | obesity | ||
| decreased DNA methylation of tyrosine hydroxylase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | obesity | ||
| decreased reward | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | decreased dopamine | ||
| decreased reward | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | decreased methylation of dopamine transporter promoter | ||
| decreased reward | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | decreased DNA methylation of tyrosine hydroxylase | ||
| decreased dopamine | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | decreased reward | ||
| chronic high fat diet | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | decreased dopamine | ||
| increased adipogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | obesity | ||
| activation of CCAAT/enhancer-binding protein alpha | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased adipogenesis | ||
| activation of CCAAT/enhancer-binding protein alpha | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of specific nuclear receptors, PPAR-gamma activation | ||
| Activation of specific nuclear receptors, PPAR-gamma activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased adipogenesis | ||
| peroxisome proliferator activated receptor promoter demethylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of specific nuclear receptors, PPAR-gamma activation | ||
| Increased, De Novo FA synthesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Liver Steatosis | ||
| Activation, LXR alpha | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, De Novo FA synthesis | ||
| Increase, Reactive Oxygen Species production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Lipid peroxidation | ||
| Increase, Follicular atresia | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Oogenesis | ||
| Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, Sustained Hepatotoxicity | ||
| Transcription of genes encoding acute phase proteins, Increased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Systemic acute phase response | ||
| Increased CGRP, neuronal release of CGRP | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Respiratory irritability and Chronic Cough, | ||
| Trigeminal nerve activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased neurokinin A (NKA) by neuronal cells | ||
| Trigeminal nerve activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Irritation of nasal mucosa inducing sneeze reflex | ||
| Hyperplasia, Hyperplasia | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Promotion, Hepatocelluar carcinoma | ||
| Trigeminal nerve activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased CGRP, neuronal release of CGRP | ||
| Trigeminal nerve activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | SP (Substance P) release, Local increase of SP | ||
| Inhibition of neurotransmitter vesicle release | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Anti-depressant Activity | ||
| hyperpolarisation, neuron | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Anti-depressant Activity | ||
| Serotonin 1A Receptor Agonism | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Release of G Proteins | ||
| Inhibition of neurotransmitter vesicle release | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Analgesia | ||
| Inhibition of N-type Ca ion channels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition of neurotransmitter vesicle release | ||
| Release of G Proteins | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition of N-type Ca ion channels | ||
| Altered, Cardiovascular development/function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Early Life Stage Mortality | ||
| hyperpolarisation, neuron | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Analgesia | ||
| Opening of G protein gated inward rectifying K channels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | hyperpolarisation, neuron | ||
| Release of G Proteins | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Opening of G protein gated inward rectifying K channels | ||
| Mu Opioid Receptor Agonism | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Release of G Proteins | ||
| Reduced, HSD17B4 activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, fatty acid beta oxidation | ||
| Reduced, PPARalpha | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, HSD17B4 activity | ||
| Activated, LXR | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, PPARalpha | ||
| Reduced, SHP activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activated, LXR | ||
| Reduced, FXR activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, SHP activity | ||
| NFE2/Nrf2 repression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, FXR activity | ||
| Increased, RDX dose | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, GABA-A receptor activation | ||
| Decreased, intracellular chloride | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activated, membrane depolarization | ||
| Reduced, GABA-A receptor activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, intracellular chloride | ||
| Decreased, GABA | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, GABA-A receptor activation | ||
| Reduced, presynaptic neuron 2 activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, GABA | ||
| Increased, seizure | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, epilepsy | ||
| Increased, hippocampal hyperdepolarization | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, seizure | ||
| Decrease, surfactant | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, mucosal defense | ||
| Helicobacter pylori infection | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, ammonium (NH4+) | ||
| Increased, leukocyte activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activated, gastric ulcer formation | ||
| Increased, leukocyte adherence | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, leukocyte activation | ||
| Reduced, PTGS2 function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, leukocyte adherence | ||
| Decreased, angiogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activated, gastric ulcer formation | ||
| Reduced, PTGS2 function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, angiogenesis | ||
| Decreased, bicarbonate | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, mucosal defense | ||
| Decreased, HSD17B10 expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity | ||
| Reduced, PTGS1 function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, bicarbonate | ||
| Decreased, mucous | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, mucosal defense | ||
| Reduced, PTGS1 function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, mucous | ||
| Reduced, mucosal defense | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activated, gastric ulcer formation | ||
| Decreased, mucosal blood flow | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, mucosal defense | ||
| Reduced, PTGS1 function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, mucosal blood flow | ||
| Reduced, platelet aggregation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activated, gastric ulcer formation | ||
| Reduced, PTGS1 function | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, platelet aggregation | ||
| Increased, extracellular serotonin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, 5-HT2A (Serotonin 2A) | ||
| Decreased, 5-HT3 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, seizure | ||
| Increased, extracellular serotonin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, 5-HT3 | ||
| Increased, serotonin transporter activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, extracellular serotonin | ||
| Increased, synaptic release | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, extracellular serotonin | ||
| Increased, packaged serotonin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, synaptic release | ||
| Increased, intracellular serotonin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, packaged serotonin | ||
| Increased, serotonin transporter activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, intracellular serotonin | ||
| Reduced, BDNF (Brain-derived neurotrophic factor) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, neuroplasticity | ||
| Increased, glucocorticoid receptor activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, BDNF (Brain-derived neurotrophic factor) | ||
| Induction, persistent proliferation/sustained proliferation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Liver Cancer | ||
| Hepatocytotoxicity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Liver Cancer | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Liver Cancer | ||
| Activation of Cyp2E1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hepatocytotoxicity | ||
| Hepatocytotoxicity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, persistent proliferation/sustained proliferation | ||
| Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hepatocytotoxicity | ||
| Activation of Cyp2E1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Oxidative Stress | ||
| Inactivated, 5-HTR (serotonin receptors) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, BDNF (Brain-derived neurotrophic factor) | ||
| Suppression, IL-2 and IL-4 production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, T-cell dependent antibody response | ||
| Reduction, NFAT/AP-1 complex formation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Suppression, IL-2 and IL-4 production | ||
| Inhibition, Calcineurin Activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Interference, nuclear localization of NFAT | ||
| Reduced levels of BDNF | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Thyroid hormone synthesis, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Thyroid hormone synthesis, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of GABAergic interneurons | ||
| Thyroid hormone synthesis, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced levels of BDNF | ||
| Inhibition, Na+/I- symporter (NIS) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Dopamine release in the brain, decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Sexual behavior, decreased | ||
| Locomotor activity, decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Reproductive Success | ||
| Sexual behavior, decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Reproductive Success | ||
| 7α-hydroxypregnenolone synthesis in the brain, decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Sexual behavior, decreased | ||
| Dopamine release in the brain, decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Locomotor activity, decreased | ||
| 7α-hydroxypregnenolone synthesis in the brain, decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Dopamine release in the brain, decreased | ||
| 7α-hydroxypregnenolone synthesis in the brain, decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Locomotor activity, decreased | ||
| CYP7B activity, inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Locomotor activity, decreased | ||
| CYP7B activity, inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | 7α-hydroxypregnenolone synthesis in the brain, decreased | ||
| Increase, surfactant | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activate, mucosal defense | ||
| Activate, phospholipase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, surfactant | ||
| Increase, ammonium (NH4+) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, surfactant | ||
| Increase, mucosal blood flow | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activate, mucosal defense | ||
| Increase, mucous | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activate, mucosal defense | ||
| Increase, bicarbonate | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activate, mucosal defense | ||
| Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, bicarbonate | ||
| Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, mucous | ||
| Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, mucosal blood flow | ||
| Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, platelet aggregation | ||
| Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, angiogenesis | ||
| Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, leukocyte adherence | ||
| Increase, leukocyte adherence | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activate, leukocyte | ||
| Activate, leukocyte | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activated, gastric ulcer formation | ||
| Activate, mucosal defense | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibit, gastric ulcer formation | ||
| Increase, platelet aggregation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibit, gastric ulcer formation | ||
| Increase, angiogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibit, gastric ulcer formation | ||
| Increase, Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Oogenesis | ||
| Increase, DNA damage | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Apoptosis | ||
| Increased, intracellular chloride (Cl-) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inactive, membrane depolarization | ||
| Activate, GABA-A receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, intracellular chloride (Cl-) | ||
| Increased, RDX dose | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activate, GABA-A receptor | ||
| Increase, GABA | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activate, GABA-A receptor | ||
| Activate, presynaptic neuron 2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, GABA | ||
| Increase, seizure | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, epilepsy | ||
| Increased, hippocampal hyperdepolarization | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, seizure | ||
| Activated, membrane depolarization | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, hippocampal hyperdepolarization | ||
| Activated, voltage-gated sodium channel | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activated, membrane depolarization | ||
| Treat, carbamazepine | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Binding to voltage-gated sodium channel | ||
| Increased, intracellular sodium (Na+) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activated, voltage-gated sodium channel | ||
| Activated, NMDA receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, intracellular sodium (Na+) | ||
| Increased, glutamate | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activated, NMDA receptor | ||
| Activated, presynaptic neuron 1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, glutamate | ||
| Activation, Glucocorticoid Receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, BDNF (Brain-derived neurotrophic factor) | ||
| Increase, cortisone | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, Glucocorticoid Receptor | ||
| Decreased, neuroplasticity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, depression | ||
| Decreased, neuroplasticity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, agitation | ||
| Reduce expression, BDNF (Brain-derived neurotrophic factor) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, neuroplasticity | ||
| Inactivated, 5-HTR (serotonin receptors) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduce expression, BDNF (Brain-derived neurotrophic factor) | ||
| Increased, 5-HT3 (5-hydroxytryptamine) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, seizure | ||
| Increase, vascular smooth muscle contraction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, hypertension | ||
| Increase, myosin light chain phosphorylation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, vascular smooth muscle contraction | ||
| Activate, calmodulin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, myosin light chain phosphorylation | ||
| Increase, intracellular calcium | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activate, calmodulin | ||
| Increase, inositol triphosphate | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, intracellular calcium | ||
| Activate, PLC (Phospholipase C) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, inositol triphosphate | ||
| Activation, 5-HT2A (Serotonin 2A) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activate, PLC (Phospholipase C) | ||
| Decreased, extracellular serotonin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, 5-HT2A (Serotonin 2A) | ||
| Decreased, extracellular serotonin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inactivated, 5-HTR (serotonin receptors) | ||
| Decreased, extracellular serotonin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, 5-HT3 (5-hydroxytryptamine) | ||
| Decreased, synaptic release | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, extracellular serotonin | ||
| Decreased, packaged serotonin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, synaptic release | ||
| Decreased, intracellular serotonin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, packaged serotonin | ||
| Decreased, serotonin transporter activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, intracellular serotonin | ||
| Decreased, serotonin transporter activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, extracellular serotonin | ||
| Reduction, Gonadotropins, circulating concentrations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Testosterone synthesis by ovarian theca cells | ||
| Decreased, serotonin transporter activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, extracellular chloride (Cl-) | ||
| Decreased, serotonin transporter activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, extracellular sodium (Na+) | ||
| Decreased, serotonin transporter activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, intracellular chloride (Cl-) | ||
| Decreased, serotonin transporter activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, intracellular sodium (Na+) | ||
| Thyroxine (T4) in serum, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hippocampal Physiology, Altered | ||
| Thyroxine (T4) in serum, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hippocampal anatomy, Altered | ||
| Thyroxine (T4) in serum, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hippocampal gene expression, Altered | ||
| Reduction, Plasma 17beta-estradiol concentrations | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Plasma vitellogenin concentrations | ||
| Agonism, Androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Vitellogenin synthesis in liver | ||
| Agonism, Androgen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, 17beta-estradiol synthesis by ovarian granulosa cells | ||
| Defect of Embryogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reproductive failure | ||
| Inhibition, Wnt pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Defect of Embryogenesis | ||
| Activation, FOXO | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, Wnt pathway | ||
| Activation, JNK | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, FOXO | ||
| Peptide Oxidation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, JNK | ||
| Glutathione homeostasis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hepatotoxicity | ||
| Perturbation of cholesterol | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hepatotoxicity | ||
| Down Regulation, GSS and GSTs gene | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Glutathione homeostasis | ||
| Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Perturbation of cholesterol | ||
| Glutathione synthesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene | ||
| Down Regulation, GSS and GSTs gene | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Glutathione synthesis | ||
| Up Regulation, Unsaturated fatty acid | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Perturbation of cholesterol | ||
| Up Regulation, SREBF2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Up Regulation, Unsaturated fatty acid | ||
| Activation, TGF-beta pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reproductive failure | ||
| Activation, JAK/STAT pathway | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, TGF-beta pathway | ||
| Apoptosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reproductive failure | ||
| Increased, DNA Damage-Repair | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Apoptosis | ||
| Activation, HIF-1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Apoptosis | ||
| Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, HIF-1 | ||
| Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, DNA Damage-Repair | ||
| ROS formation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK | ||
| Activation, NADPH Oxidase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | ROS formation | ||
| N/A, Gap | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Ca and HCO3 transport to shell gland | ||
| Collagen Deposition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Lung fibrosis | ||
| Inactivation of PPARγ | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation of TGF-β signaling | ||
| Increase, COX-2 expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Cardiovascular development/function | ||
| dimerization, AHR/ARNT | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, COX-2 expression | ||
| Decrease, Excitatory postsynaptic potential | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Abdominal muscle contraction | ||
| Decrease, Ecdysis motoneuron bursts | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Excitatory postsynaptic potential | ||
| Decrease, Circulating crustacean cardioactive peptide | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Ecdysis motoneuron bursts | ||
| Decrease, Circulating ecdysis triggering hormone | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Circulating crustacean cardioactive peptide | ||
| Increase, Fushi tarazu factor-1 gene expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, Circulating ecdysis triggering hormone | ||
| Increase, Nuclear receptor E75b gene expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Fushi tarazu factor-1 gene expression | ||
| Increase, Ecdysone receptor agonism | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Nuclear receptor E75b gene expression | ||
| Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, oocyte maturation | ||
| Increased, serotonin (5-HT) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased mantel display | ||
| Increase, cilia movement | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induced parturition | ||
| Increased, valve movement | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induced parturition | ||
| Increased, serotonin (5-HT) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, cilia movement | ||
| Increased, serotonin (5-HT) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, muscular waves in foot | ||
| MLL chromosomal translocation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Infant leukaemia | ||
| Activation, FAS | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Synthesis, De Novo Fatty Acid (FA) | ||
| Increased, oocyte maturation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | induced spawning | ||
| Increased, serotonin (5-HT) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, valve movement | ||
| Induced parturition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reproductive Success | ||
| induced spawning | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reproductive Success | ||
| Induced parturition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Reproductive Success | ||
| increased mantel display | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induced parturition | ||
| Increase, cilia movement | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | induced spawning | ||
| Increased, valve movement | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | induced spawning | ||
| Increase, FA Influx | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Triglyceride | ||
| Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | increased mantel display | ||
| Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, cilia movement | ||
| Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, valve movement | ||
| Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, muscular waves in foot | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Ca2+-calmodulin activated signal transduction | ||
| Altered, Ca2+-calmodulin activated signal transduction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Desensitization, Nicotinic acetylcholine receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Ca2+-calmodulin activated signal transduction | ||
| Increased, Second Messenger Production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Non-genomic signaling | ||
| Activation, Estrogen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Second Messenger Production | ||
| Increased, Motility | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Invasion | ||
| Altered, Protein Production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Motility | ||
| Altered, Protein Production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Apoptosis (Epithelial Cells) | ||
| Altered, Protein Production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Proliferation (Endothelial cells) | ||
| Increased, Non-genomic signaling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Gene Expression | ||
| Increase, DNA damage | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Gene Expression | ||
| Increased, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, DNA damage | ||
| Altered, Protein Production | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Oxidative Stress | ||
| Altered, Gene Expression | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Protein Production | ||
| Increased, ER binding to T.F. to DNA (non-classical pathway) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Gene Expression | ||
| Increased, ER binding to DNA (classical pathway) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Gene Expression | ||
| Increased, Non-genomic signaling | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, ER binding to T.F. to DNA (non-classical pathway) | ||
| Activation, Estrogen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Non-genomic signaling | ||
| Antagonism, Estrogen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, Vitellogenin synthesis in liver | ||
| Agonism, Estrogen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Vitellogenin synthesis in liver | ||
| Opening of calcium channel, Calcium influx | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Trigeminal nerve activation | ||
| TRPA1 activation, TRPA1 Receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Opening of calcium channel, Calcium influx | ||
| Agonism, Estrogen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired development of, Reproductive organs | ||
| Altered gene expression specific to CAR activation, Hepatocytes | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, cell proliferation (hepatocytes) | ||
| Activation, Constitutive androstane receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered gene expression specific to CAR activation, Hepatocytes | ||
| Increased, Migration (Endothelial Cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Angiogenesis | ||
| Increased, Proliferation (Endothelial cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Angiogenesis | ||
| Decline, Population | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Alteration, Food-web structures | ||
| Increased, Male offspring | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decline, Population | ||
| Induction, Male reproductive tract | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Male offspring | ||
| Induction, Doublesex1 gene | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, Male reproductive tract | ||
| Activation, Juvenile hormone receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, Doublesex1 gene | ||
| Agonism, Estrogen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Reproductive behaviour | ||
| Increased, Ductal Hyperplasia | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Breast Cancer | ||
| Increased, ER binding to T.F. to DNA (non-classical pathway) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell Proliferation (Epithelial Cells) | ||
| Increased, ER binding to DNA (classical pathway) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Cell Proliferation (Epithelial Cells) | ||
| Impairment, Endothelial network | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Insufficiency, Vascular | ||
| Activation, Estrogen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, ER binding to T.F. to DNA (non-classical pathway) | ||
| Decreased, Apoptosis (Epithelial Cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Ductal Hyperplasia | ||
| Increase, Cell Proliferation (Epithelial Cells) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Ductal Hyperplasia | ||
| Activation, Estrogen receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, ER binding to DNA (classical pathway) | ||
| Decreased, sodium conductance 2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, GABA release | ||
| Inhibition, sodium channel | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, sodium conductance 2 | ||
| Increase, cell proliferation (hepatocytes) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Clonal Expansion of Altered Hepatic Foci | ||
| Increase, Clonal Expansion of Altered Hepatic Foci | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, hepatocellular adenomas and carcinomas | ||
| Increase, Phenotypic enzyme activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, cell proliferation (hepatocytes) | ||
| Reduction, Eggshell thickness | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | N/A, Reproductive failure | ||
| Activation, PPARα | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Phenotypic enzyme activity | ||
| Increased, valve movement | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, predation | ||
| Increased, water retention in foot | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, valve movement | ||
| Increased, Reproductive Success | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Population | ||
| Increased, serotonin (5-HT) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, oocyte maturation | ||
| Activation, Hepatic nuclear receptor(s) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, Upregulation of glucuronyltransferase activity | ||
| Activation, Hepatic nuclear receptor(s) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Hepatic thyroid hormone uptake/transport | ||
| Inhibition, Dual oxidase | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Thyroid hormone synthesis, Decreased | ||
| Inhibition, Pendrin | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Thyroid hormone synthesis, Decreased | ||
| Inhibition, Deiodinase 3 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Triiodothyronine (T3) in tissues | ||
| Inhibition, Deiodinase 2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Triiodothyronine (T3) in tissues | ||
| Inhibition, Deiodinase 1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Triiodothyronine (T3) in tissues | ||
| Inhibition, Iodotyrosine deiodinase (IYD) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease of Thyroidal iodide | ||
| Depletion, energy reserves | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, predation | ||
| Increased, locomotion | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Depletion, energy reserves | ||
| Increased, foot detachment | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Depletion, energy reserves | ||
| Increased, water retention in foot | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, foot detachment | ||
| Increased, valve movement | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, water retention in foot | ||
| Increased, valve movement | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Depletion, energy reserves | ||
| Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impaired recruitment , Population trajectory | ||
| Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction | ||
| Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal | ||
| Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) | ||
| Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin) | ||
| Hemostasis, Depletion from blood of fully functional carboxylated clotting factors | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis | ||
| Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hemostasis, Depletion from blood of fully functional carboxylated clotting factors | ||
| Decreased, Triiodothyronine (T3) in tissues | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Altered, Amphibian metamorphosis | ||
| Increased, Reactive oxygen species | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Oxidative Stress | ||
| Unknown, MIE | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Reactive oxygen species | ||
| Increased, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, renal proximal tubular necrosis | ||
| Occurrence, renal ischemia | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Oxidative Stress | ||
| Increased, blood uric acid concentration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Oxidative Stress | ||
| Increased, Energetic demands and therefore metabolic stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Abnormal, Foraging activity and behavior | ||
| Occurrence, renal proximal tubular necrosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, blood uric acid concentration | ||
| Increased, Deformed Wing Virus levels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Weakened, Colony | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Weakened, Colony | ||
| impaired, Hive thermoregulation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Weakened, Colony | ||
| Mitochondrial dysfunction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | impaired, Hive thermoregulation | ||
| Abnormal, Role change within caste | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Weakened, Colony | ||
| Abnormal, Foraging activity and behavior | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Abnormal, Role change within caste | ||
| Activation, Nicotinic acetylcholine receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Weakened, Colony | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Death/Failure, Colony | ||
| Abnormal, Foraging activity and behavior | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Weakened, Colony | ||
| Occurrence, cardiac arrhythmia | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Mortality | ||
| Increased, blood potassium concentration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, cardiac arrhythmia | ||
| Decreased, Prostaglandin F2alpha concentration, plasma | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, renal ischemia | ||
| Inhibition, Cyclooxygenase 1 activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Prostaglandin F2alpha concentration, plasma | ||
| Occurrence, renal proximal tubular necrosis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, blood potassium concentration | ||
| Occurrence, tophi (urate) deposition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, renal proximal tubular necrosis | ||
| Increased, blood uric acid concentration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Occurrence, tophi (urate) deposition | ||
| Inhibition, organic anion transporter 1 (OAT1) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, blood uric acid concentration | ||
| Increased, Cell Proliferation (mesothelium) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, mesotheliomas | ||
| Increased, secretion of local growth factors | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Cell Proliferation (mesothelium) | ||
| Increased, Oxidative Stress | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secretion of local growth factors | ||
| Increased, inflammation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secretion of local growth factors | ||
| persistent, cytotoxicity (pleura or peritoneum) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Oxidative Stress | ||
| persistent, cytotoxicity (pleura or peritoneum) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, inflammation | ||
| Increased, hyperplasia (mammary gland) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Adenomas/carcinomas (mammary) | ||
| Increased, hyperplasia (mammary gland) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, latency period | ||
| Increased, prolactin secretion | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, hyperplasia (mammary gland) | ||
| Decreased, Dopaminergic activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, prolactin secretion | ||
| Increased, lactotroph hyperplasia and hypertrophy | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, adenomas (pituitary) | ||
| Increased, circulating estrogen levels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, lactotroph hyperplasia and hypertrophy | ||
| interruption, Ovulation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, circulating estrogen levels | ||
| Increased, latency period | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Adenomas/carcinomas (mammary) | ||
| Hyperplasia, Mammary gland | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Adenomas/carcinomas (mammary) | ||
| Hyperplasia, Mammary gland | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, latency period | ||
| Increased, prolactin exposure | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hyperplasia, Mammary gland | ||
| Increased, circulating estrogen levels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hyperplasia, Mammary gland | ||
| prolonged, estrus | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, prolactin exposure | ||
| prolonged, estrus | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, circulating estrogen levels | ||
| Decreased, LH Surge from anterior pituitary | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | prolonged, estrus | ||
| Decreased, LH Surge from anterior pituitary | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | interruption, Ovulation | ||
| Decreased, GnRH pulsatility/release in hypothalamus | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, LH Surge from anterior pituitary | ||
| Increased, Hyperplasia (glandular epithelial cells of endometrium) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, adenosquamous carcinomas of endometrium | ||
| squamous metaplasia, aberrant basal cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Hyperplasia (glandular epithelial cells of endometrium) | ||
| Proliferation/Clonal Expansion, aberrant basal cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | squamous metaplasia, aberrant basal cells | ||
| Promotion, SIX-1 postive basal-type progenitor cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Proliferation/Clonal Expansion, aberrant basal cells | ||
| Activation, estrogen receptor alpha | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Promotion, SIX-1 postive basal-type progenitor cells | ||
| prepubertal increase, Estrogen receptor (ER) activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Activation, estrogen receptor alpha | ||
| Decreased, bile flow | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, cholestasis | ||
| Increased, cholestasis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | prolonged, elevation of serun CCK | ||
| Synthesis, De Novo Fatty Acid (FA) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Triglyceride | ||
| Acetylcholinesterase (AchE) Inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Acetylcholine accumulation in synapses | ||
| Increased, Cellular proliferation / hyperplasia of acinar cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Pancreatic acinar tumors | ||
| prolonged, elevation of serun CCK | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Cellular proliferation / hyperplasia of acinar cells | ||
| Increased, PPAR-alpha activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Alteration, lipid metabolism | ||
| Increased, PPAR-alpha activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, cholestasis | ||
| Increased, PPAR-alpha activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, bile flow | ||
| Hyperplasia, ovarian stromal cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Promotion, ovarian granular cell tumors | ||
| Hyperplasia, ovarian epithelium | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Promotion, ovarian adenomas | ||
| Increased, secretion of LH from anterior pituitary | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hyperplasia, ovarian stromal cells | ||
| Increased, secrection of FSH from anterior pituitary | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hyperplasia, ovarian epithelium | ||
| Increased, secrection of FSH from anterior pituitary | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hyperplasia, ovarian stromal cells | ||
| Increased, secretion of GnRH from hypothalamus | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secretion of LH from anterior pituitary | ||
| Increased, secretion of GnRH from hypothalamus | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secrection of FSH from anterior pituitary | ||
| Decrease, E2 blood concentrations at hypothalamus | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secretion of GnRH from hypothalamus | ||
| Suppression, Estrogen receptor (ER) activity | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, E2 blood concentrations at hypothalamus | ||
| Decreased, Ovarian E2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, E2 blood concentrations at hypothalamus | ||
| Hypertrophy/hyperplasia, smooth muscle | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Promotion, mesovarian leiomyomas | ||
| Proliferation/Clonal Expansion, smooth muscle | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Hypertrophy/hyperplasia, smooth muscle | ||
| relaxation, smooth muscle | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Proliferation/Clonal Expansion, smooth muscle | ||
| Increased activity, beta-2 adrenergic receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | relaxation, smooth muscle | ||
| Release, Cytokine | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Inflammation | ||
| Activation, beta-2 adrenergic receptor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased activity, beta-2 adrenergic receptor | ||
| Increased, proliferation of mesenchymal cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, hemagiosarcoma | ||
| Increased, proliferation of mesenchymal cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, liposarcoma | ||
| Increased, proliferation of mesenchymal cells | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Firbrosarcoma | ||
| Increased, secretion of local growth factors | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, IGF-1 (mouse) | ||
| Increased, secretion of local growth factors | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, proliferation of mesenchymal cells | ||
| Increased, adipogenesis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secretion of local growth factors | ||
| Activation of specific nuclear receptors, PPAR-gamma activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, secretion of local growth factors | ||
| Activation of specific nuclear receptors, PPAR-gamma activation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, adipogenesis | ||
| Inhibition, UROD | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Accumulation, Highly carboxylated porphyrins | ||
| N/A, Neurodegeneration | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Impairment, Learning and memory | ||
| Antagonism, Histamine Receptor (H2) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decrease, histaminergic neuron excitation | ||
| Induction, pharyngeal muscle paralysis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, Feeding | ||
| Increased, Inhibitory postsynaptic potential | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, pharyngeal muscle paralysis | ||
| Activation, Glutamate-gated chloride channels | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Chloride conductance | ||
| Inhibition, Feeding | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Mortality | ||
| Induction, Somatic muscle paralysis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Inhibition, Feeding | ||
| Increased, Inhibitory postsynaptic potential | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Induction, Somatic muscle paralysis | ||
| Increased, Neuronal synaptic inhibition | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Inhibitory postsynaptic potential | ||
| Increased, Chloride conductance | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Neuronal synaptic inhibition | ||
| Activation, ionotropic GABA Receptor chloride channel | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Chloride conductance | ||
| Induction, Somatic muscle paralysis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased Mortality | ||
| Inhibition, Deiodinase 1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Posterior swim bladder inflation | ||
| Inhibition, Deiodinase 2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Posterior swim bladder inflation | ||
| Thyroxine (T4) in serum, Decreased | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Anterior swim bladder inflation | ||
| Inhibition, Deiodinase 1 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Triiodothyronine (T3) | ||
| Insufficiency, Vascular | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increased, Developmental Defects | ||
| Decreased, Triiodothyronine (T3) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Anterior swim bladder inflation | ||
| Reduced, Anterior swim bladder inflation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Swimming performance | ||
| Reduced, Posterior swim bladder inflation | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Swimming performance | ||
| Decreased, Triiodothyronine (T3) | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduced, Posterior swim bladder inflation | ||
| Inhibition, Deiodinase 2 | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, Triiodothyronine (T3) | ||
| stabilization, PPAR alpha co-repressor | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Decreased, PPARalpha transactivation of gene expression | ||
| Binding of antagonist, PPAR alpha | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | stabilization, PPAR alpha co-repressor | ||
| Interference, nuclear localization of NFAT | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Reduction, NFAT/AP-1 complex formation | ||
| Decrease, Abdominal muscle contraction | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Incomplete ecdysis | ||
| Increase, Incomplete ecdysis | https://h2020-sbd4nano.github.io/sbd-data-aopwiki/relationships/ | Increase, Mortality | ||
| lysosomal damage | https://www.sbd4nano.eu/bel/#correlates | ROS production | ||
| cathepsins | https://www.sbd4nano.eu/bel/#correlates | mitochondrial damage | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#correlates | aggregation | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | aggregation | ||
| Dose | https://www.sbd4nano.eu/bel/#correlates | aggregation | ||
| Dose | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | aggregation | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#correlates | ROS production | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | ROS production | ||
| Dose | https://www.sbd4nano.eu/bel/#correlates | ROS production | ||
| Dose | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | ROS production | ||
| lysosomal damage | https://www.sbd4nano.eu/bel/#correlates | cathepsins | ||
| cell uptake (amount) | https://www.sbd4nano.eu/bel/#correlates | lysosomal damage | ||
| Phagocytosis | https://www.sbd4nano.eu/bel/#kindOf | cell uptake (type) | ||
| size | https://www.sbd4nano.eu/bel/#correlates | Phagocytosis | ||
| Pottasium | https://www.sbd4nano.eu/bel/#correlates | inflammasome activation | ||
| caspase-1 | https://www.sbd4nano.eu/bel/#correlates | mature IL-1β | ||
| pro-caspase-1 | https://www.sbd4nano.eu/bel/#correlates | caspase-1 | ||
| pro-interleukin (IL)-1β | https://www.sbd4nano.eu/bel/#correlates | mature IL-1β | ||
| NF-κB activation | https://www.sbd4nano.eu/bel/#correlates | pro-interleukin (IL)-1β | ||
| NF-κB activation | https://www.sbd4nano.eu/bel/#correlates | NLRP3 expression | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | cell viability | ||
| core composition | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell viability | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#correlates | cell viability | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell viability | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | Zeta-potential | ||
| core composition | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | Zeta-potential | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#correlates | Zeta-potential | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | Zeta-potential | ||
| inflammasome activation | https://www.sbd4nano.eu/bel/#correlates | pro-caspase-1 | ||
| inflammasome activation | https://www.sbd4nano.eu/bel/#correlates | apoptosis-associated speck-like protein containing a CARD | ||
| inflammasome activation | https://www.sbd4nano.eu/bel/#correlates | NLRP3 expression | ||
| ROS production | https://www.sbd4nano.eu/bel/#correlates | inflammasome activation | ||
| ROS production | https://www.sbd4nano.eu/bel/#correlates | oxidative stress | ||
| NADPH oxidase (NOX1) activation | https://www.sbd4nano.eu/bel/#correlates | ROS production | ||
| aspect ratio (HARN) | https://www.sbd4nano.eu/bel/#correlates | NADPH oxidase (NOX1) activation | ||
| aspect ratio (HARN) | https://www.sbd4nano.eu/bel/#correlates | frustrated phagocytosis | ||
| Toll-like receptors | https://www.sbd4nano.eu/bel/#correlates | NF-κB activation | ||
| Toll-like receptors | https://www.sbd4nano.eu/bel/#partOf | cell membrane | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| exposure | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | cell uptake (amount) | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| core composition | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | cell uptake (amount) | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | charge | ||
| exposure | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | charge | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | charge | ||
| core composition | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | charge | ||
| Pathogen-associated molecular patterns | https://www.sbd4nano.eu/bel/#recognizedBy | Toll-like receptors | ||
| lipopolysaccharides | https://www.sbd4nano.eu/bel/#kindOf | Pathogen-associated molecular patterns | ||
| medium | https://www.sbd4nano.eu/bel/#correlates | light | ||
| light | https://www.sbd4nano.eu/bel/#positivelyCorrelates | photo-reactivity | ||
| surface charge | https://www.sbd4nano.eu/bel/#correlates | cytotoxicity | ||
| surface charge | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| surface charge | https://www.sbd4nano.eu/bel/#correlates | charge | ||
| Zeta-potential | https://www.sbd4nano.eu/bel/#correlates | sedimentation rate | ||
| deformability | https://www.sbd4nano.eu/bel/#correlates | shape | ||
| deformability | https://www.sbd4nano.eu/bel/#correlates | size | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | ROS production | ||
| core composition | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | ROS production | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | ROS production | ||
| exposure | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | ROS production | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | dissolution | ||
| core composition | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | dissolution | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | dissolution | ||
| exposure | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | dissolution | ||
| charge | https://www.sbd4nano.eu/bel/#correlates | protein corona | ||
| protein corona | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| cell uptake (type) | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| liver/spleen activity | https://www.sbd4nano.eu/bel/#negativelyCorrelates | concentration | ||
| surface area | https://www.sbd4nano.eu/bel/#correlates | dissolution | ||
| surface area | https://www.sbd4nano.eu/bel/#positivelyCorrelates | photo-reactivity | ||
| size | https://www.sbd4nano.eu/bel/#correlates | protein corona | ||
| ROS production | https://www.sbd4nano.eu/bel/#correlates | cytotoxicity | ||
| ROS production | https://www.sbd4nano.eu/bel/#unknown | cytotoxicity | ||
| size | https://www.sbd4nano.eu/bel/#correlates | cytotoxicity | ||
| size | https://www.sbd4nano.eu/bel/#unknown | cytotoxicity | ||
| ROS production | https://www.sbd4nano.eu/bel/#correlates | cell uptake (type) | ||
| ROS production | https://www.sbd4nano.eu/bel/#unknown | cell uptake (type) | ||
| size | https://www.sbd4nano.eu/bel/#correlates | cell uptake (type) | ||
| size | https://www.sbd4nano.eu/bel/#unknown | cell uptake (type) | ||
| exposure | https://www.sbd4nano.eu/bel/#unknown | ROS production | ||
| size | https://www.sbd4nano.eu/bel/#correlates | ROS production | ||
| size | https://www.sbd4nano.eu/bel/#unknown | ROS production | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | liver/spleen activity | ||
| exposure | https://www.sbd4nano.eu/bel/#unknown | liver/spleen activity | ||
| size | https://www.sbd4nano.eu/bel/#correlates | liver/spleen activity | ||
| size | https://www.sbd4nano.eu/bel/#unknown | liver/spleen activity | ||
| size | https://www.sbd4nano.eu/bel/#correlates | surface area | ||
| size | https://www.sbd4nano.eu/bel/#unknown | surface area | ||
| time of exposure | https://www.sbd4nano.eu/bel/#correlates | surface area | ||
| time of exposure | https://www.sbd4nano.eu/bel/#unknown | surface area | ||
| size | https://www.sbd4nano.eu/bel/#correlates | toxicity | ||
| size | https://www.sbd4nano.eu/bel/#unknown | toxicity | ||
| time of exposure | https://www.sbd4nano.eu/bel/#correlates | toxicity | ||
| time of exposure | https://www.sbd4nano.eu/bel/#unknown | toxicity | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | quantum and tunneling effects | ||
| exposure | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | quantum and tunneling effects | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | quantum and tunneling effects | ||
| core composition | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | quantum and tunneling effects | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | lactate dehydrogenase | ||
| exposure | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | lactate dehydrogenase | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | lactate dehydrogenase | ||
| core composition | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | lactate dehydrogenase | ||
| Dose | https://www.sbd4nano.eu/bel/#correlates | toxicity | ||
| Dose | https://www.sbd4nano.eu/bel/#unknown | toxicity | ||
| size | https://www.sbd4nano.eu/bel/#correlates | kidney activity | ||
| size | https://www.sbd4nano.eu/bel/#unknown | kidney activity | ||
| Dose | https://www.sbd4nano.eu/bel/#correlates | kidney activity | ||
| Dose | https://www.sbd4nano.eu/bel/#unknown | kidney activity | ||
| cell type | https://www.sbd4nano.eu/bel/#correlates | toxicity | ||
| cell type | https://www.sbd4nano.eu/bel/#unknown | toxicity | ||
| size | https://www.sbd4nano.eu/bel/#correlates | dissolution | ||
| size | https://www.sbd4nano.eu/bel/#unknown | dissolution | ||
| cell type | https://www.sbd4nano.eu/bel/#correlates | dissolution | ||
| cell type | https://www.sbd4nano.eu/bel/#unknown | dissolution | ||
| size | https://www.sbd4nano.eu/bel/#negativelyCorrelates | toxicity | ||
| layers | https://www.sbd4nano.eu/bel/#negativelyCorrelates | toxicity | ||
| layers | https://www.sbd4nano.eu/bel/#unknown | toxicity | ||
| size | https://www.sbd4nano.eu/bel/#negativelyCorrelates | photo-reactivity | ||
| size | https://www.sbd4nano.eu/bel/#unknown | photo-reactivity | ||
| layers | https://www.sbd4nano.eu/bel/#negativelyCorrelates | photo-reactivity | ||
| layers | https://www.sbd4nano.eu/bel/#unknown | photo-reactivity | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#correlates | aggregation | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#unknown | aggregation | ||
| size | https://www.sbd4nano.eu/bel/#correlates | aggregation | ||
| size | https://www.sbd4nano.eu/bel/#unknown | aggregation | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#correlates | toxicity | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#unknown | toxicity | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#correlates | toxicity | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#unknown | toxicity | ||
| enzyme degredation | https://www.sbd4nano.eu/bel/#correlates | toxicity | ||
| enzyme degredation | https://www.sbd4nano.eu/bel/#unknown | toxicity | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#correlates | concentration | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#unknown | concentration | ||
| enzyme degredation | https://www.sbd4nano.eu/bel/#correlates | concentration | ||
| enzyme degredation | https://www.sbd4nano.eu/bel/#unknown | concentration | ||
| kidney activity | https://www.sbd4nano.eu/bel/#negativelyCorrelates | concentration | ||
| kidney activity | https://www.sbd4nano.eu/bel/#unknown | concentration | ||
| ROS production | https://www.sbd4nano.eu/bel/#negativelyCorrelates | concentration | ||
| ROS production | https://www.sbd4nano.eu/bel/#unknown | concentration | ||
| kidney activity | https://www.sbd4nano.eu/bel/#negativelyCorrelates | oxidative stress | ||
| kidney activity | https://www.sbd4nano.eu/bel/#unknown | oxidative stress | ||
| ROS production | https://www.sbd4nano.eu/bel/#negativelyCorrelates | oxidative stress | ||
| ROS production | https://www.sbd4nano.eu/bel/#unknown | oxidative stress | ||
| dissolution | https://www.sbd4nano.eu/bel/#correlates | crystal structure | ||
| dissolution | https://www.sbd4nano.eu/bel/#unknown | crystal structure | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | crystal structure | ||
| exposure | https://www.sbd4nano.eu/bel/#unknown | crystal structure | ||
| dissolution | https://www.sbd4nano.eu/bel/#correlates | ROS production | ||
| dissolution | https://www.sbd4nano.eu/bel/#unknown | ROS production | ||
| dissolution | https://www.sbd4nano.eu/bel/#correlates | toxicity | ||
| dissolution | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | toxicity | ||
| amination | https://www.sbd4nano.eu/bel/#correlates | toxicity | ||
| amination | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | toxicity | ||
| dissolution | https://www.sbd4nano.eu/bel/#correlates | cell uptake (type) | ||
| dissolution | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | cell uptake (type) | ||
| amination | https://www.sbd4nano.eu/bel/#correlates | cell uptake (type) | ||
| amination | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | cell uptake (type) | ||
| Dose | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | toxicity | ||
| dissolution | https://www.sbd4nano.eu/bel/#correlates | environmental fate | ||
| dissolution | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | environmental fate | ||
| Dose | https://www.sbd4nano.eu/bel/#correlates | environmental fate | ||
| Dose | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | environmental fate | ||
| membrane crossing | https://www.sbd4nano.eu/bel/#positivelyCorrelates | toxicity | ||
| membrane crossing | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | toxicity | ||
| Dose | https://www.sbd4nano.eu/bel/#positivelyCorrelates | toxicity | ||
| membrane crossing | https://www.sbd4nano.eu/bel/#positivelyCorrelates | cell uptake (amount) | ||
| membrane crossing | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | cell uptake (amount) | ||
| Dose | https://www.sbd4nano.eu/bel/#positivelyCorrelates | cell uptake (amount) | ||
| Dose | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | cell uptake (amount) | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | reactivity | ||
| core composition | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | reactivity | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | reactivity | ||
| exposure | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | reactivity | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | activation of caspase-3 | ||
| core composition | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | activation of caspase-3 | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | activation of caspase-3 | ||
| exposure | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | activation of caspase-3 | ||
| cell uptake (amount) | https://www.sbd4nano.eu/bel/#correlates | concentration | ||
| cell uptake (amount) | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | concentration | ||
| PEGylation | https://www.sbd4nano.eu/bel/#correlates | concentration | ||
| PEGylation | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | concentration | ||
| cell uptake (amount) | https://www.sbd4nano.eu/bel/#correlates | toxicity | ||
| cell uptake (amount) | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | toxicity | ||
| PEGylation | https://www.sbd4nano.eu/bel/#correlates | toxicity | ||
| PEGylation | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | toxicity | ||
| time of exposure | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | ROS production | ||
| time of exposure | https://www.sbd4nano.eu/bel/#positivelyCorrelates | ROS production | ||
| photo-reactivity | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | ROS production | ||
| photo-reactivity | https://www.sbd4nano.eu/bel/#positivelyCorrelates | ROS production | ||
| time of exposure | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell viability | ||
| time of exposure | https://www.sbd4nano.eu/bel/#positivelyCorrelates | cell viability | ||
| photo-reactivity | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell viability | ||
| photo-reactivity | https://www.sbd4nano.eu/bel/#positivelyCorrelates | cell viability | ||
| exposure route | https://www.sbd4nano.eu/bel/#correlates | cell viability | ||
| exposure route | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell viability | ||
| Dose | https://www.sbd4nano.eu/bel/#correlates | cell viability | ||
| Dose | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell viability | ||
| exposure route | https://www.sbd4nano.eu/bel/#correlates | organ (type) | ||
| exposure route | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | organ (type) | ||
| Dose | https://www.sbd4nano.eu/bel/#correlates | organ (type) | ||
| Dose | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | organ (type) | ||
| exposure route | https://www.sbd4nano.eu/bel/#correlates | cytotoxicity | ||
| exposure route | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | cytotoxicity | ||
| Dose | https://www.sbd4nano.eu/bel/#correlates | cytotoxicity | ||
| Dose | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | cytotoxicity | ||
| exposure route | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| exposure route | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | cell uptake (amount) | ||
| Dose | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| Dose | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | cell uptake (amount) | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | concentration | ||
| exposure | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | concentration | ||
| exposure route | https://www.sbd4nano.eu/bel/#correlates | concentration | ||
| exposure route | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | concentration | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | toxicity | ||
| exposure | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | toxicity | ||
| exposure route | https://www.sbd4nano.eu/bel/#correlates | toxicity | ||
| exposure route | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | toxicity | ||
| exposure route | https://www.sbd4nano.eu/bel/#correlates | medium | ||
| exposure route | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | medium | ||
| Dose | https://www.sbd4nano.eu/bel/#correlates | medium | ||
| Dose | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | medium | ||
| exposure route | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | toxicity | ||
| concentration | https://www.sbd4nano.eu/bel/#correlates | protein corona | ||
| concentration | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | protein corona | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | protein corona | ||
| exposure | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | protein corona | ||
| concentration | https://www.sbd4nano.eu/bel/#correlates | immunoproteasome LMP7 | ||
| concentration | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | immunoproteasome LMP7 | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | immunoproteasome LMP7 | ||
| exposure | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | immunoproteasome LMP7 | ||
| exposure | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell uptake (amount) | ||
| exposure | https://www.sbd4nano.eu/bel/#positivelyCorrelates | cell uptake (amount) | ||
| concentration | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell uptake (amount) | ||
| concentration | https://www.sbd4nano.eu/bel/#positivelyCorrelates | cell uptake (amount) | ||
| exposure | https://www.sbd4nano.eu/bel/#positivelyCorrelates | immunoproteasome LMP7 | ||
| concentration | https://www.sbd4nano.eu/bel/#positivelyCorrelates | immunoproteasome LMP7 | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | aggregation | ||
| exposure | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | aggregation | ||
| concentration | https://www.sbd4nano.eu/bel/#correlates | aggregation | ||
| concentration | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | aggregation | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | Toll-like receptors | ||
| exposure | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | Toll-like receptors | ||
| concentration | https://www.sbd4nano.eu/bel/#correlates | Toll-like receptors | ||
| concentration | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | Toll-like receptors | ||
| medium | https://www.sbd4nano.eu/bel/#correlates | autophagy | ||
| medium | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | autophagy | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | autophagy | ||
| exposure | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | autophagy | ||
| medium | https://www.sbd4nano.eu/bel/#correlates | protein corona | ||
| medium | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | protein corona | ||
| exposure | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | protein corona | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | exfoliation | ||
| core composition | https://www.sbd4nano.eu/bel/#Correlates | exfoliation | ||
| Hydrophilicity | https://www.sbd4nano.eu/bel/#correlates | exfoliation | ||
| Hydrophilicity | https://www.sbd4nano.eu/bel/#Correlates | exfoliation | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | interaction potential | ||
| core composition | https://www.sbd4nano.eu/bel/#Correlates | interaction potential | ||
| Hydrophilicity | https://www.sbd4nano.eu/bel/#correlates | interaction potential | ||
| Hydrophilicity | https://www.sbd4nano.eu/bel/#Correlates | interaction potential | ||
| medium | https://www.sbd4nano.eu/bel/#correlates | granuloma formation | ||
| medium | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | granuloma formation | ||
| Dose | https://www.sbd4nano.eu/bel/#correlates | granuloma formation | ||
| Dose | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | granuloma formation | ||
| medium | https://www.sbd4nano.eu/bel/#correlates | dissolution | ||
| medium | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | dissolution | ||
| Dose | https://www.sbd4nano.eu/bel/#correlates | dissolution | ||
| Dose | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | dissolution | ||
| medium | https://www.sbd4nano.eu/bel/#correlates | toxicity | ||
| medium | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | toxicity | ||
| medium | https://www.sbd4nano.eu/bel/#correlates | aggregation | ||
| medium | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | aggregation | ||
| aggregation | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | toxicity | ||
| Dose | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | toxicity | ||
| aggregation | https://www.sbd4nano.eu/bel/#correlates | toxicity | ||
| aggregation | https://www.sbd4nano.eu/bel/#correlates | apoptosis | ||
| aggregation | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | apoptosis | ||
| Dose | https://www.sbd4nano.eu/bel/#correlates | apoptosis | ||
| Dose | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | apoptosis | ||
| aggregation | https://www.sbd4nano.eu/bel/#correlates | membrane crossing | ||
| aggregation | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | membrane crossing | ||
| Dose | https://www.sbd4nano.eu/bel/#correlates | membrane crossing | ||
| Dose | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | membrane crossing | ||
| aggregation | https://www.sbd4nano.eu/bel/#correlates | environmental fate | ||
| aggregation | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | environmental fate | ||
| Dose | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | environmental fate | ||
| aggregation | https://www.sbd4nano.eu/bel/#correlates | cell adhesion | ||
| aggregation | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell adhesion | ||
| Dose | https://www.sbd4nano.eu/bel/#correlates | cell adhesion | ||
| Dose | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell adhesion | ||
| aggregation | https://www.sbd4nano.eu/bel/#correlates | cytotoxicity | ||
| aggregation | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | cytotoxicity | ||
| Dose | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | cytotoxicity | ||
| aggregation | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| aggregation | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | cell uptake (amount) | ||
| Dose | https://www.sbd4nano.eu/bel/#correlates | reactivity | ||
| Dose | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | reactivity | ||
| aggregation | https://www.sbd4nano.eu/bel/#correlates | reactivity | ||
| aggregation | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | reactivity | ||
| aggregation | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | cytotoxicity | ||
| interaction potential | https://www.sbd4nano.eu/bel/#correlates | aggregation | ||
| interaction potential | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | aggregation | ||
| interaction potential | https://www.sbd4nano.eu/bel/#correlates | ROS production | ||
| interaction potential | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | ROS production | ||
| exposure | https://www.sbd4nano.eu/bel/#correlates | photo-reactivity | ||
| exposure | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | photo-reactivity | ||
| crystal structure | https://www.sbd4nano.eu/bel/#correlates | photo-reactivity | ||
| crystal structure | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | photo-reactivity | ||
| crystal structure | https://www.sbd4nano.eu/bel/#correlates | ROS production | ||
| crystal structure | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | ROS production | ||
| temperature | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| temperature | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | cell uptake (amount) | ||
| stacks | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| stacks | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | cell uptake (amount) | ||
| temperature | https://www.sbd4nano.eu/bel/#correlates | size | ||
| temperature | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | size | ||
| stacks | https://www.sbd4nano.eu/bel/#correlates | size | ||
| stacks | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | size | ||
| Surface charge | https://www.sbd4nano.eu/bel/#correlates | crystal structure | ||
| Surface charge | https://www.sbd4nano.eu/bel/#Correlates | crystal structure | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | crystal structure | ||
| core composition | https://www.sbd4nano.eu/bel/#Correlates | crystal structure | ||
| Surface charge | https://www.sbd4nano.eu/bel/#correlates | Hydrophilicity | ||
| Surface charge | https://www.sbd4nano.eu/bel/#Correlates | Hydrophilicity | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | Hydrophilicity | ||
| core composition | https://www.sbd4nano.eu/bel/#Correlates | Hydrophilicity | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#correlates | size | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | size | ||
| length | https://www.sbd4nano.eu/bel/#correlates | size | ||
| length | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | size | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | cell uptake (amount) | ||
| length | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| length | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | cell uptake (amount) | ||
| cell type | https://www.sbd4nano.eu/bel/#correlates | size | ||
| cell type | https://www.sbd4nano.eu/bel/#Correlates | size | ||
| diameter | https://www.sbd4nano.eu/bel/#correlates | size | ||
| diameter | https://www.sbd4nano.eu/bel/#Correlates | size | ||
| cell type | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| cell type | https://www.sbd4nano.eu/bel/#Correlates | cell uptake (amount) | ||
| diameter | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| diameter | https://www.sbd4nano.eu/bel/#Correlates | cell uptake (amount) | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#positivelyCorrelates | cell uptake (amount) | ||
| diameter | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | cell uptake (amount) | ||
| diameter | https://www.sbd4nano.eu/bel/#positivelyCorrelates | cell uptake (amount) | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | toxicity | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#positivelyCorrelates | toxicity | ||
| diameter | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | toxicity | ||
| diameter | https://www.sbd4nano.eu/bel/#positivelyCorrelates | toxicity | ||
| shape | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| shape | https://www.sbd4nano.eu/bel/#Correlates | cell uptake (amount) | ||
| shape | https://www.sbd4nano.eu/bel/#correlates | protein corona | ||
| shape | https://www.sbd4nano.eu/bel/#Correlates | protein corona | ||
| shape | https://www.sbd4nano.eu/bel/#correlates | cell uptake (type) | ||
| shape | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell uptake (type) | ||
| Surface charge | https://www.sbd4nano.eu/bel/#correlates | cell uptake (type) | ||
| Surface charge | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell uptake (type) | ||
| shape | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell uptake (amount) | ||
| Surface charge | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| Surface charge | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell uptake (amount) | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#correlates | cell viability | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell viability | ||
| Mn-impurity | https://www.sbd4nano.eu/bel/#correlates | cell viability | ||
| Mn-impurity | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell viability | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#correlates | ultraviolet shielding function | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | ultraviolet shielding function | ||
| Mn-impurity | https://www.sbd4nano.eu/bel/#correlates | ultraviolet shielding function | ||
| Mn-impurity | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | ultraviolet shielding function | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#correlates | protein corona | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | protein corona | ||
| Mn-impurity | https://www.sbd4nano.eu/bel/#correlates | protein corona | ||
| Mn-impurity | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | protein corona | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | toxicity | ||
| Mn-impurity | https://www.sbd4nano.eu/bel/#correlates | toxicity | ||
| Mn-impurity | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | toxicity | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | cell viability | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | cell viability | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#correlates | cell uptake (type) | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | cell uptake (type) | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#correlates | cell uptake (type) | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#DoesNotCorrelate | cell uptake (type) | ||
| activation of caspase-3 | https://www.sbd4nano.eu/bel/#correlates | dissolution | ||
| activation of caspase-3 | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | dissolution | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#correlates | dissolution | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | dissolution | ||
| activation of caspase-3 | https://www.sbd4nano.eu/bel/#correlates | Apoptosis | ||
| activation of caspase-3 | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | Apoptosis | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#correlates | Apoptosis | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#PositivelyCorrelates | Apoptosis | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#correlates | ROS production | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | ROS production | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | ROS production | ||
| lateral dimension | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell uptake (amount) | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#correlates | cell uptake (amount) | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#NegativelyCorrelates | cell uptake (amount) | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#Correlates | protein corona | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | protein corona | ||
| core composition | https://www.sbd4nano.eu/bel/#Correlates | protein corona | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#correlates | Surface charge | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#Correlates | Surface charge | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | Surface charge | ||
| core composition | https://www.sbd4nano.eu/bel/#Correlates | Surface charge | ||
| core composition | https://www.sbd4nano.eu/bel/#correlates | Suspension | ||
| core composition | https://www.sbd4nano.eu/bel/#Correlates | Suspension | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#correlates | Suspension | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#Correlates | Suspension | ||
| core composition | https://www.sbd4nano.eu/bel/#Correlates | dissolution | ||
| coating/surface chemistry | https://www.sbd4nano.eu/bel/#Correlates | dissolution |
curl -s https://raw.githubusercontent.com/h2020-sbd4nano/sbd-data-book/master/sparql/allCausalRelationships.rq | sed 's+<lang/>+en+' > allCausalRelationships.rq
curl -H "Accept: text/tab-separated-values" -G https://sbd4nanolandscape.rdf.bigcat-bioinformatics.org/sparql --data-urlencode query@allCausalRelationships.rq
This SPARQL query is available under CCZero.