sbd-data-book

relationshipsByCause.rq

Code examples: curl

SPARQL

PREFIX sbd:     <https://www.sbd4nano.eu/rdf/#>
PREFIX sbdbel:  <https://www.sbd4nano.eu/bel/#>
PREFIX dc:      <http://purl.org/dc/elements/1.1/>
PREFIX dcterms: <http://purl.org/dc/terms/>
PREFIX sbdbel2:  <https://h2020-sbd4nano.github.io/sbdbel/>

SELECT ?cause (COUNT(DISTINCT ?relation) AS ?count)
WHERE {
  VALUES ?ca { sbdbel:CausalAssertion sbd:CausalAssertion sbdbel2:CausalAssertion }
  ?relation a ?ca ;
    sbdbel:cause / rdfs:label ?cause .
} GROUP BY ?cause
  ORDER BY DESC(?count) ASC(?cause)

run

Output

cause	count
Mitochondrial dysfunction	31
Oxidative Stress	26
Deposition of Energy	23
Activation, AhR	20
Dose	14
exposure	13
Thyroxine (T4) in serum, Decreased	13
Cell injury/death	13
Increased, Reactive oxygen species	13
Increase, Oxidative Stress	12
Activation, LXR	11
Acetylcholinesterase (AchE) Inhibition	10
Increase, DNA damage	10
coating/surface chemistry	9
core composition	9
size	9
Apoptosis	9
Deposition of Ionizing Energy	9
Increase, Reactive Oxygen Species production	9
Agonism, Androgen receptor	8
Decrease, testosterone levels	8
Histone deacetylase inhibition	8
Increase, DNA strand breaks	8
Activation, PPARα	7
Epithelial Mesenchymal Transition	7
Increase, Inflammation	7
Increased Pro-inflammatory mediators	7
Increased, Oxidative Stress	7
N/A, Neurodegeneration	7
Overactivation, NMDARs	7
lateral dimension	6
Altered, Transcription of genes by the androgen receptor	6
Decrease, Adenosine triphosphate pool	6
Decreased, serotonin transporter activity	6
Increase, Apoptosis	6
Increase, Cell Proliferation	6
Increase, Mutations	6
Increased SARS-CoV-2 production	6
Increased, recruitment of inflammatory cells	6
Increased, secretion of proinflammatory mediators	6
Increased, serotonin (5-HT)	6
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	6
Non-coding RNA expression profile alteration	6
Peptide Oxidation	6
Reduced levels of BDNF	6
Substance interaction with the lung resident cell membrane components	6
Thyroid hormone synthesis, Decreased	6
aggregation	5
Activation, estrogen receptor alpha	5
Decrease of neuronal network function	5
Decrease, androgen receptor activation	5
Decreased spermatogenesis	5
Decreased, Neuronal network function in adult brain	5
Decreased, Triiodothyronine (T3)	5
Disturbance, Lysosomal function	5
Estrogen receptor alpha inactivation	5
Increase, Cell death	5
Increase, Oxidative damage to DNA	5
Increased Cholinergic Signaling	5
Increased, Intracellular Calcium overload	5
Increased, glutamate	5
Increased, valve movement	5
Inhibition, Cyclooxygenase activity	5
Neuroinflammation	5
Oxidative Stress in Brain	5
peroxisome proliferator activated receptor promoter demethylation	5
ROS production	4
exposure route	4
medium	4
Activation of PPAR	4
Activation, Androgen receptor	4
Activation, Estrogen receptor	4
Activation, Glucocorticoid Receptor	4
Activation, Long term AHR receptor driven direct and indirect gene expression changes	4
Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1)	4
Agonism, Retinoic acid receptor	4
Alkylation, DNA	4
Altered Signaling Pathways	4
Altered, Meiotic chromosome dynamics	4
Altered, Protein Production	4
Antagonism, Thyroid Receptor	4
Binding to ACE2	4
Covalent Binding, Protein	4
Damage, Lipid bilayer	4
Decrease, Coupling of oxidative phosphorylation	4
Decrease, Mitochondrial ATP production	4
Impairment, Learning and memory	4
Inadequate DNA repair	4
Increase in reactive oxygen and nitrogen species (RONS)	4
Increase, Incomplete ecdysis	4
Increase, intracellular calcium	4
Increased activation, Nuclear factor kappa B (NF-kB)	4
Increased, DNA damage and mutation	4
Increased, Lipid peroxidation	4
Inhibition, Aromatase	4
Inhibition, Na+/I- symporter (NIS)	4
Inhibition, Nuclear factor kappa B (NF-kB)	4
Loss of alveolar capillary membrane integrity	4
N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)	4
NFE2/Nrf2 repression	4
Occurrence, Cystic dilatation (renal tubule)	4
Occurrence, Cytoplasmic vacuolization (Renal tubule)	4
Occurrence, Cytoplasmic vacuolization (podocyte)	4
Reduced, PTGS1 function	4
Reduced, Swimming performance	4
Reduction, Plasma 17beta-estradiol concentrations	4
Release, Cytokine	4
Synaptic dysfunction	4
Trigeminal nerve activation	4
dimerization, AHR/ARNT	4
concentration	3
dissolution	3
inflammasome activation	3
surface charge	3
7α-hydroxypregnenolone synthesis in the brain, decreased	3
Abnormal, Foraging activity and behavior	3
Accumulation of misfolded proteins	3
Accumulation, Collagen	3
Accumulation, Fatty acid	3
Acetylcholine accumulation in synapses	3
Activated, presynaptic neuron 1	3
Activation of Cyp2E1	3
Activation of specific nuclear receptors, PPAR-gamma activation	3
Activation, Glutamate-gated chloride channels	3
Activation, JNK	3
Activation, Nicotinic acetylcholine receptor	3
Activation, PXR/SXR	3
Agonism, Estrogen receptor	3
Alveolar collapse	3
Antagonism, Androgen receptor	3
Antagonism, Estrogen receptor	3
Bile accumulation, Pathological condition	3
Binding of (ant)agonist to peroxisome proliferator–activated receptor alpha	3
Bradykinin system, hyperactivated	3
Damaging, Red blood cells; hemolysis	3
Decrease, ATP production	3
Decrease, Cell proliferation	3
Decrease, Oxidative phosphorylation	3
Decrease, dihydrotestosterone (DHT) level	3
Decreased, Mitochondrial fatty acid beta-oxidation	3
Decreased, Triiodothyronine (T3) in tissues	3
Decreased, extracellular serotonin	3
Degeneration of dopaminergic neurons of the nigrostriatal pathway	3
Formation, Pro-mutagenic DNA Adducts	3
Frustrated phagocytosis	3
Hippocampal Physiology, Altered	3
Increase in inflammation	3
Increase, CNS Neural cell death	3
Increase, Cell membrane depolarization	3
Increase, Cytotoxicity (epithelial cells)	3
Increase, DNA double-strand breaks	3
Increase, Oocyte apoptosis	3
Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	3
Increase, cell proliferation (hepatocytes)	3
Increase, slincR expression	3
Increased Angiotensin II	3
Increased, PPAR-alpha activation	3
Increased, Serum creatinine	3
Increased, circulating estrogen levels	3
Increased, proliferation of mesenchymal cells	3
Increased, secretion of local growth factors	3
Induction, Somatic muscle paralysis	3
Inhibition, Deiodinase 1	3
Inhibition, Deiodinase 2	3
Inhibition, Mitochondrial Electron Transport Chain Complexes	3
Inhibition, NADH-ubiquinone oxidoreductase (complex I)	3
Inhibition, Phospholipase A	3
Leukocyte recruitment/activation	3
Occurrence, renal proximal tubular necrosis	3
Unfolded Protein Response	3
decreased reward	3
hyperpolarisation, neuron	3
increased，Vascular endothelial dysfunction	3
Mn-impurity	2
NF-κB activation	2
Surface charge	2
Toll-like receptors	2
aspect ratio (HARN)	2
cell type	2
cell uptake (amount)	2
deformability	2
diameter	2
lysosomal damage	2
shape	2
surface area	2
time of exposure	2
Abnormal, Roll change within caste	2
Accumulation, Cytosolic toxic Tau oligomers	2
Accumulation, Triglyceride	2
Activation of ER stress	2
Activation of Tumor Protein 53	2
Activation of inflammation pathway	2
Activation, ChREBP	2
Activation, EGFR	2
Activation, Hepatic nuclear receptor(s)	2
Activation, NR1H4	2
Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2)	2
Activation, Pregnane-X receptor, NR1l2	2
Activation, SREBF1	2
Activation, Stellate cells	2
Activation, TGF-beta pathway	2
Activation, Transforming Growth Factor beta pathway	2
Activation/Proliferation, T-cells	2
Alkylation, Protein	2
Alterations, Cellular proliferation / hyperplasia	2
Altered gene expression, NRF2 dependent antioxidant pathway	2
Altered, Gene Expression	2
Altered, Visual function	2
Altered, cholesterol metabolism	2
Antagonism, Smoothened receptor	2
Binding of (ant)agonist to liver X receptor	2
Binding, Transthyretin in serum	2
Binding, Tubulin	2
Bulky DNA adducts, increase	2
CYP7B activity, inhibition	2
Cell cycle, disrupted	2
Coagulation	2
Cortisol and 11β-(OH) testosterone decreased	2
Decrease of egg production and cummulative fecundity	2
Decrease, Calcium currents	2
Decrease, Cardiac contractility	2
Decrease, Fecundity	2
Decrease, GLI1/2 target gene expression	2
Decrease, Global DNA methylation	2
Decrease, Leaf development	2
Decrease, Mitochondrial membrane potential	2
Decrease, Number of worker bees	2
Decrease, Oogenesis	2
Decrease, Photosynthesis	2
Decrease, Reproduction	2
Decrease, Sonic Hedgehog second messenger production	2
Decrease, histaminergic neuron excitation	2
Decrease, knickkopf gene	2
Decrease, sox9 expression	2
Decrease, testosterone synthesis/level	2
Decreased Na/K ATPase activity	2
Decreased proliferation of cortical neural progenitor cells	2
Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells	2
Decreased, plasma 11-ketotestosterone level	2
Decreased, Apoptosis (Epithelial Cells)	2
Decreased, LH Surge from anterior pituitary	2
Decreased, PPAR-gamma activation	2
Decreased, PPARalpha transactivation of gene expression	2
Decreased, Sodium conductance 1	2
Decreased, all-trans retinoic acid (atRA) concentration	2
Decreased, cholesterol	2
Decreased, neuroplasticity	2
Delay, Ovarian maturation	2
Desensitization, Nicotinic acetylcholine receptor	2
Diminished protective oxidative stress response	2
Disrupted Lipid Storage	2
Disruption, Lysosome	2
Disruption, Mitochondrial electron transport chain	2
Disruption, neurotransmitter release	2
Dopamine release in the brain, decreased	2
Down Regulation, GSS and GSTs gene	2
Dysfunctional Autophagy	2
Dysregulation, ACE2 expression and activity	2
Fibrinolysis, decreased	2
General Apoptosis	2
Genomic instability	2
Glucocorticoid Receptor Agonist, Activation	2
Hepatocytotoxicity	2
Hippocampal gene expression, Altered	2
Histone acetylation, increase	2
Hyperplasia, Mammary gland	2
Impaired axonial transport	2
Impaired coordination and movement	2
Impaired, Proteostasis	2
Impaired, Spermatogenesis	2
Impairment, Endothelial network	2
Inactivated, 5-HTR (serotonin receptors)	2
Inactivation of PPARγ	2
Increase, Caspase transcription	2
Increase, Caspase transcription (F3)	2
Increase, Cell Proliferation (Epithelial Cells)	2
Increase, Chromosomal aberrations	2
Increase, Cripto-1 expression	2
Increase, Cytotoxicity	2
Increase, Cytotoxicity (renal tubular cell)	2
Increase, DNA methyltransferase inhibition	2
Increase, Defects in tanning of new cuticle	2
Increase, Hyperplasia (glandular epithelial cells of endometrium)	2
Increase, Hyperplasia (urothelial)	2
Increase, Mitochondrial complex III antagonism	2
Increase, Oxidative DNA damage	2
Increase, Pro-Inflammatory Mediators	2
Increase, Reactive oxygen species	2
Increase, Regenerative cell proliferation (tubular epithelial cells)	2
Increase, angiogenesis	2
Increase, cilia movement	2
Increased Mortality	2
Increased fat mass	2
Increased intracelluar Iron accumulation	2
Increased, Chloride conductance	2
Increased, De Novo FA synthesis	2
Increased, ER binding to DNA (classical pathway)	2
Increased, ER binding to T.F. to DNA (non-classical pathway)	2
Increased, Estrogen receptor (ER) activity	2
Increased, FA Influx	2
Increased, Free serum thyroxine (T4)	2
Increased, Hepatic thyroid hormone uptake/transport	2
Increased, Induced Mutations in Critical Genes	2
Increased, Inhibitory postsynaptic potential	2
Increased, Migration (Endothelial Cells)	2
Increased, Neuronal synaptic inhibition	2
Increased, Non-genomic signaling	2
Increased, RDX dose	2
Increased, Thyroid-stimulating hormone (TSH)	2
Increased, Thyroxine (T4) in serum	2
Increased, Viral susceptibility	2
Increased, blood uric acid concentration	2
Increased, extracellular serotonin	2
Increased, hippocampal hyperdepolarization	2
Increased, hyperplasia (mammary gland)	2
Increased, locomotion	2
Increased, muscular waves in foot	2
Increased, predation	2
Increased, secrection of FSH from anterior pituitary	2
Increased, secretion of GnRH from hypothalamus	2
Increased, secretion of LH from anterior pituitary	2
Increased, serotonin transporter activity	2
Increased, water retention in foot	2
Induced dysregulation of ACE2	2
Induced parturition	2
Induction, CYP1A2/CYP1A5	2
Inflamatory events in light-exposed tissues	2
Inhibition of Ceramide Synthase	2
Inhibition of lung surfactant function	2
Inhibition of neurotransmitter vesicle release	2
Inhibition, Cytochrome P450 enzyme (CYP17A1) activity	2
Inhibition, Feeding	2
Inhibition, FoxA2	2
Inhibition, Iodotyrosine deiodinase (IYD)	2
Inhibition, Mitochondrial fatty acid beta-oxidation	2
Inhibition, NMDARs	2
Inhibition, sodium channel	2
Inositol triphosphate receptor activation	2
Insulin resistance, increased	2
KE4 : Uncoupling, eNOS	2
Lipid Peroxidation	2
N/A, Androgen receptor, Antagonism	2
N/A, Unknown	2
Neural crest cell migration, reduced	2
Occurrence, Ballooning degeneration (hepatocyte)	2
Occurrence, Cytoplasmic vacuolization (Bile duct cell)	2
Occurrence, Cytoplasmic vacuolization (hepatocyte)	2
Occurrence, Cytoplasmic vacuolization (kupffer cell)	2
PFOS binding PPAR isoforms resulting in disrupted nuclear signaling	2
Prolonged TLR9 activation	2
Propagation, Oxidative stress	2
Proteasomal dysfunction	2
ROS generation from photoactivated chemicals	2
Reduced, Maturation inducing steroid receptor signalling, oocyte	2
Reduced, PTGS2 function	2
Reduced, Posterior swim bladder inflation	2
Reduced, Prostaglandin F2alpha concentration, plasma	2
Reduced, feeding 1	2
Reduced, swimming speed	2
Reduction, Cumulative fecundity and spawning	2
Reduction, Plasma vitellogenin concentrations	2
Reduction, Testosterone synthesis in Leydig cells	2
Release of G Proteins	2
Respiratory distress/arrest	2
SARS-CoV-2 cell entry	2
Sensory axonal peripheral neuropathy	2
Status epilepticus	2
Suppression, Constitutive androstane receptor, NR1l3	2
Suppression, Estrogen receptor (ER) activity	2
Sustentacular cells, decrease	2
Thyroperoxidase, Inhibition	2
Thyroxine (T4) in neuronal tissue, Decreased	2
Tissue resident cell activation	2
Up Regulation, CD36	2
Up Regulation, SCD-1	2
activation of CCAAT/enhancer-binding protein alpha	2
benzoquinone imine and acylglucuronide metabolites	2
decreased DNA methylation of tyrosine hydroxylase	2
decreased methylation of dopamine transporter promoter	2
impaired, Fertility	2
impaired, Hive thermoregulation	2
increase oxidation of the di-copper moiety of the hemocyanin active site	2
olfactory sensory neurons, decrease	2
persistent, cytotoxicity (pleura or peritoneum)	2
prolonged, estrus	2
reduced production, VEGF	2
Hydrophilicity	1
NADPH oxidase (NOX1) activation	1
PEGylation	1
Pathogen-associated molecular patterns	1
Phagocytosis	1
Pottasium	1
Zeta-potential	1
activation of caspase-3	1
amination	1
caspase-1	1
cathepsins	1
cell uptake (type)	1
charge	1
crystal structure	1
enzyme degredation	1
interaction potential	1
kidney activity	1
layers	1
length	1
light	1
lipopolysaccharides	1
liver/spleen activity	1
membrane crossing	1
photo-reactivity	1
pro-caspase-1	1
pro-interleukin (IL)-1β	1
protein corona	1
stacks	1
temperature	1
MLL chromosomal translocation	1
11β-hydroxylase inhibition	1
Aberrant, Dendritic morphology	1
Aberrant, synaptic formation and plasticity	1
Abnormal expression of NO	1
Abnormal, Glucose homeostasis	1
Abnormal, Role change within caste	1
Accelerated, Aging	1
Accumulation, Damaged mitochondrial DNA	1
Accumulation, Highly carboxylated porphyrins	1
Acinar cell proliferation	1
Activate, GABA-A receptor	1
Activate, PLC (Phospholipase C)	1
Activate, calmodulin	1
Activate, leukocyte	1
Activate, mucosal defense	1
Activate, phospholipase	1
Activate, presynaptic neuron 2	1
Activated AKT/ERK/PI3K pathway	1
Activated ANG/Tie2 pathway	1
Activated BMP/TGF-beta pathway	1
Activated Wnt/Frizzled pathway	1
Activated, LXR	1
Activated, NMDA receptor	1
Activated, membrane depolarization	1
Activated, voltage-gated sodium channel	1
Activation Sema6A	1
Activation of Angiogenic cytokines	1
Activation of MMP-2 MMP-9	1
Activation of TGF-β signaling	1
Activation of angiopoietin like protein 4	1
Activation of calpain signalling	1
Activation of hepatic stellate cells	1
Activation of metabotropic glutamate receptor	1
Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2	1
Activation of specific nuclear receptors, Transcriptional change	1
Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene	1
Activation, 5-HT2A (Serotonin 2A)	1
Activation, 5HT2c	1
Activation, AKT2	1
Activation, Caspase 8 pathway	1
Activation, Constitutive androstane receptor	1
Activation, Dendritic Cells	1
Activation, Dll4-Notch pathway	1
Activation, FAS	1
Activation, FOXO	1
Activation, Glutamate-gated chloride channel	1
Activation, HIF-1	1
Activation, HIF1α	1
Activation, JAK/STAT pathway	1
Activation, Juvenile hormone receptor	1
Activation, Keratinocytes	1
Activation, LXR alpha	1
Activation, Latent Transforming Growth Factor Beta 1	1
Activation, Microglia	1
Activation, Muscarinic Acetylcholine Receptors	1
Activation, NADPH Oxidase	1
Activation, NRF2	1
Activation, PARP1	1
Activation, SCD-1	1
Activation, SHP	1
Activation, SREBP-1c	1
Activation, Tissue resident cells (Kuppfer cells)	1
Activation, beta-2 adrenergic receptor	1
Activation, caspases	1
Activation, ionotropic GABA Receptor chloride channel	1
Activator protein 1 activation	1
Affected folate transporter	1
Airway Surface Liquid Height, Decreased	1
Airway epithelial injury	1
Airway remodeling	1
Alteration, Wnt pathway	1
Alteration, lipid metabolism	1
Altered Bone Cell Homeostasis	1
Altered Liver X receptor activity	1
Altered brain morphology	1
Altered differentiation	1
Altered expression of cell cycle genes	1
Altered gene expression specific to CAR activation, Hepatocytes	1
Altered, Action Potential	1
Altered, Ca2+-calmodulin activated signal transduction	1
Altered, Cardiovascular development/function	1
Altered, Chromosome number	1
Altered, Neuroanatomy	1
Altered, Neurophysiology	1
Altered, Nitric Oxide Levels	1
Altered, Photoreceptor patterning	1
Altered, Thyroid hormone-dependent gene expression	1
Altered, retinal layer structure	1
Altered, white brain matter	1
Angiogenesis dysfunction	1
Antagonism, Histamine Receptor (H2)	1
Antagonism,LH receptor	1
Apoptotic cell death	1
Binding at picrotoxin site, iGABAR chloride channel	1
Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)	1
Binding of agonist, Ionotropic glutamate receptors	1
Binding of antagonist to glucocorticoid hormone receptor	1
Binding of antagonist to thyroid hormone receptor	1
Binding of antagonist, NMDA receptors	1
Binding of antagonist, PPAR alpha	1
Binding of inhibitor to mitochondrial complex III	1
Binding of inhibitor to mitochondrial complex IV	1
Binding of inhibitor to mitochondrial complex V	1
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)	1
Binding of microtubule stabilizing agents (MSA) to microtubules	1
Binding of substrate, endocytic receptor	1
Binding to (interferes with) topoisomerase II enzyme	1
Binding to estrogen receptor (ER)-α in immune cells	1
Binding to voltage-gated sodium channel	1
Binding, Thiol/seleno-proteins involved in protection against oxidative stress	1
Binding, Thyroid binding globulin in serum	1
Blockade of STAT5 phosphorylation	1
Blockade, L-Type Calcium Channels	1
Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal	1
CYP2E1 Activation	1
Changes/Inhibition, Cellular Homeostasis and Apoptosis	1
Chronic reactive oxygen species	1
Cilia Beat Frequency, Decreased	1
Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)	1
Cognitive, sensed as hypoxic/low oxygen environment	1
Collagen Deposition	1
Collagen production, reduced	1
Conjugation, GSH	1
Cystic Fibrosis Transmembrane Regulator Function, Decreased	1
Decline, Population	1
Decompartmentalization	1
Decrease in mitochondrial oxidative phosphorylation	1
Decrease of GABAergic interneurons	1
Decrease of Thyroidal iodide	1
Decrease of synaptogenesis	1
Decrease, 20-hydroxyecdysone	1
Decrease, Abdominal muscle contraction	1
Decrease, Acyl-CoA dehydrogenases	1
Decrease, Bioactivation of testosterone	1
Decrease, Calcium binding to Troponin C	1
Decrease, Cardiac ejection fraction	1
Decrease, Chitin laminar organization	1
Decrease, Chlorophyll synthesis	1
Decrease, Circulating crustacean cardioactive peptide	1
Decrease, Circulating ecdysis triggering hormone	1
Decrease, Cuticular chitin content	1
Decrease, Digestion of old cuticle	1
Decrease, E2 blood concentrations at hypothalamus	1
Decrease, Ecdysis motoneuron bursts	1
Decrease, Excitatory postsynaptic potential	1
Decrease, Fecundity (F3)	1
Decrease, GLI1/2 translocation to nucleus	1
Decrease, GLUT4	1
Decrease, Glucose pool	1
Decrease, Glucose uptake	1
Decrease, Glycolysis	1
Decrease, Growth	1
Decrease, Heritable DNA methylation (F3)	1
Decrease, Intracellular pH	1
Decrease, Leaf cell mitosis	1
Decrease, Light harvest capacity	1
Decrease, Neutral lipids	1
Decrease, New cuticle secretion	1
Decrease, Oogenesis (F3)	1
Decrease, Ovulation	1
Decrease, Photosystem II efficiency	1
Decrease, Prevent chitin degradation by chitinases	1
Decrease, Smoothend relocation and activation	1
Decrease, Steroidogenic acute regulatory protein (STAR)	1
Decrease, Translocator protein (TSPO)	1
Decrease, Tyrosine	1
Decrease, dopa decarboxylase	1
Decrease, elavl3	1
Decrease, expression of gonadotropin releasing hormone receptor	1
Decrease, mbp	1
Decrease, palatal shelf outgrowth	1
Decrease, sox10	1
Decrease, surfactant	1
Decreased SIRT1 expression	1
Decreased plasma Cortisol level	1
Decreased plasma RA level	1
Decreased protection against oxidative stress	1
Decreased proximal tubular vectorial transport	1
Decreased retinoic acid (RA) synthesis	1
Decreased sperm quantity or quality in the adult, Decreased fertility	1
Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity	1
Decreased, 5-HT3	1
Decreased, Androgen and Progestin	1
Decreased, Androgen receptor activity	1
Decreased, Aromatase (Cyp19a1) mRNA	1
Decreased, Calcium influx	1
Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII)	1
Decreased, DHB4/HSD17B4	1
Decreased, Dopaminergic activity	1
Decreased, Eye size	1
Decreased, GABA	1
Decreased, Glomerular filtration	1
Decreased, Glucose oxidase enzyme activity	1
Decreased, GnRH pulsatility/release in hypothalamus	1
Decreased, Gonadotropins	1
Decreased, HSD17B10 expression	1
Decreased, Hydrogen peroxide production	1
Decreased, Insulin-like peptide 3 (INSL3)	1
Decreased, Ketogenesis	1
Decreased, Ketogenesis (production of ketone bodies)	1
Decreased, Lymphocytes	1
Decreased, Maturation Inducing Steroid Surge by Granulosa cells	1
Decreased, Mitochondrial Fatty Acid Beta Oxidation	1
Decreased, Nitric Oxide	1
Decreased, Ovarian E2	1
Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)	1
Decreased, PPAR-alpha activation	1
Decreased, PPAR-beta activation	1
Decreased, Progesterone from corpus luteum	1
Decreased, Prolactin	1
Decreased, Prostaglandin F2alpha concentration, plasma	1
Decreased, Prostaglandin F2alpha synthesis, ovary	1
Decreased, Renal ability to dilute urine	1
Decreased, Renal plasma flow	1
Decreased, Reproductive Success	1
Decreased, Sodium reabsorption	1
Decreased, Testosterone binding to androgen receptor (hypothalamus)	1
Decreased, Viable Offspring	1
Decreased, angiogenesis	1
Decreased, anxiety	1
Decreased, bicarbonate	1
Decreased, bile flow	1
Decreased, intracellular chloride	1
Decreased, intracellular serotonin	1
Decreased, locomotion	1
Decreased, mevalonate	1
Decreased, mucosal blood flow	1
Decreased, mucous	1
Decreased, oxygen binding capacity by hemocyanin	1
Decreased, packaged serotonin	1
Decreased, sheltering	1
Decreased, sodium conductance 2	1
Decreased, synaptic release	1
Defect of Embryogenesis	1
Depletion, GSH	1
Depletion, energy reserves	1
Depletion, mtDNA	1
Direct mitochondrial inhibition	1
Disorganization, Meiotic Spindle	1
Displacement, Serum thyroxine (T4) from carrier protein	1
Displacement, Serum thyroxine (T4) from transthyretin	1
Disrupted meiotic initiation of fetal oogonia of the ovary	1
Disruption of sodium channel gating kinetics	1
Disruption, Intracellular calcium mobilization	1
Disruption, Microtubule dynamics	1
Disruption, Progenitor cells of second heart field	1
Disruption, Sarcomere assembly	1
Disturbance in microtubule dynamic instability	1
Down Regulation, CPT1A	1
Down Regulation, HMGCS2	1
Downregulation, ACE2	1
Dysregulation of heart rate and vascular tone	1
Emphysema	1
Endocytotic lysosomal uptake	1
Endoplasmic reticulum stress	1
Endothelial cell dysfunction	1
Epididymal agenesis	1
Epigenetic modification process	1
Expression of factors ruling proliferation, modified	1
FOXJ1 Protein, Decreased	1
Facial cartilage structures are reduced in size and morphologically distorted	1
Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)	1
Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage)	1
Fatty Acid Beta Oxidation, Decreased	1
Feminisation or incomplete development, Primary and accessory male sex organs	1
Fibroblast proliferation and differentiation	1
Fibroproliferative airway lesions	1
Formation, Mallory body	1
GSK3beta inactivation	1
Generation, Amplified excitatory postsynaptic potential (EPSP)	1
Glutamate dyshomeostasis	1
Glutathione homeostasis	1
Glutathione synthesis	1
Granulosa cell proliferation of gonadotropin-independent follicles, Reduced	1
Helicobacter pylori infection	1
Hemostasis, Depletion from blood of fully functional carboxylated clotting factors	1
Hippocampal anatomy, Altered	1
Hyperactivation of ACE/Ang-II/AT1R axis	1
Hyperplasia, Hyperplasia	1
Hyperplasia, Leydig cell	1
Hyperplasia, ovarian epithelium	1
Hyperplasia, ovarian stromal cells	1
Hypertrophy/hyperplasia, smooth muscle	1
Hypomyelination	1
IFNγ signaling	1
Imbalanced salty and sweet taste responses	1
Immune cell activation	1
Immune mechanisms antagonized by viral proteins	1
Impaired IL-1R1 signaling in T cell	1
Impaired Platelet Aggregation	1
Impaired gustatory nerve	1
Impaired inguinoscrotal testicular descent phase	1
Impaired insulin signaling	1
Impaired ovulation	1
Impaired, Oocyte maturation and ovulation	1
Impaired, urethral tube closure	1
Increase Chromosomal Aberrations	1
Increase of Th2 cells producing IL-4	1
Increase of anti-DNA antibody from autoreactive B cell	1
Increase plasma Ang II	1
Increase proliferation, Leydig cell	1
Increase, impairment of cuticle sclerotization	1
Increase, pigmentation	1
Increase, Abnormal Neural Remodeling	1
Increase, Abnormal osmoregulation	1
Increase, Alcohol dehydrogenase	1
Increase, Androgen receptor	1
Increase, Body fluid overload	1
Increase, Body volume of female adults	1
Increase, Bone Remodeling	1
Increase, COX-2 expression	1
Increase, Ca++ (intracellular)	1
Increase, Clonal Expansion of Altered Hepatic Foci	1
Increase, Cytochrome c release	1
Increase, Cytosolic calcium	1
Increase, Cytotoxicity (club cells)	1
Increase, Cytotoxicity (corneal cells)	1
Increase, Cytotoxicity (hepatocytes)	1
Increase, Cytotoxicity (tubular epithelial cells)	1
Increase, Cytotoxicity (urothelial cells)	1
Increase, DNA methyltransferase expression	1
Increase, Differentiation of fibroblasts	1
Increase, Dopaminergic activity	1
Increase, Ecdysone receptor agonism	1
Increase, Endothelial Dysfunction	1
Increase, Energetic demands and therefore metabolic stress	1
Increase, FA Influx	1
Increase, Follicular atresia	1
Increase, Formation of DNA photoproducts	1
Increase, Fushi tarazu factor-1 gene expression	1
Increase, GABA	1
Increase, Global DNA methylation	1
Increase, Glycolysis	1
Increase, Gonadotropins concentration in plasma	1
Increase, Hyperplasia (Leydig cells)	1
Increase, Hyperplasia (follicular cells)	1
Increase, Hyperplasia (forestomach epithelial cells)	1
Increase, Hyperplasia (renal tubular cells)	1
Increase, Hyperplasia (terminal bronchiolar cells)	1
Increase, Hyperplasia (tubular epithelial cells)	1
Increase, Hypertrophy and proliferation (follicular cell)	1
Increase, IL-23 from matured dendritic cells	1
Increase, Inflammation (corneal cells)	1
Increase, Liver and splenic hemosiderosis	1
Increase, Luteinizing hormone (LH)	1
Increase, Mitochondrial ATP synthase antagonism	1
Increase, Mitochondrial swelling	1
Increase, Mucin production	1
Increase, Mutations in Critical Genes	1
Increase, Necrosis	1
Increase, Necrosis (terminal bronchiolar cells)	1
Increase, Nuclear receptor E75b gene expression	1
Increase, Oocyte apoptosis (F3)	1
Increase, Opening of voltage-dependent calcium channel	1
Increase, Ovarian follicle breakdown	1
Increase, Ovarian follicle breakdown (F3)	1
Increase, Ovarian somatic cell apoptosis	1
Increase, Ovarian somatic cell apoptosis (F3)	1
Increase, Oxidative metabolism	1
Increase, Oxygen-evolving complex damage	1
Increase, Phenotypic enzyme activity	1
Increase, Plasma vitellogenin concentrations	1
Increase, Pollen abnormal	1
Increase, Premature molting	1
Increase, Preneoplastic foci (hepatocytes)	1
Increase, Programmed cell death	1
Increase, Protein oxidation	1
Increase, RBC congestion in liver	1
Increase, Regenerative cell proliferation (corneal cells)	1
Increase, Regenerative cell proliferation (forestomach epithelial cells)	1
Increase, Regenerative cell proliferation (hepatocytes)	1
Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)	1
Increase, Regenerative cell proliferation (urothelial cells)	1
Increase, Renal pathology due to VTG deposition	1
Increase, Respiratory or Squamous Metaplasia	1
Increase, Sulfonylurea receptor binding	1
Increase, TNF	1
Increase, Tissue Degeneration, Necrosis & Atrophy	1
Increase, Uncoupling of photophosphorylation	1
Increase, Urinary bladder calculi	1
Increase, Vitellogenin mRNA	1
Increase, Vitellogenin synthesis in liver	1
Increase, ammonium (NH4+)	1
Increase, bicarbonate	1
Increase, cortisone	1
Increase, cytosolic fatty acid	1
Increase, developmental abnormalities	1
Increase, goblet cell number	1
Increase, hypermethylation of the promotor region of gonadotropin releasing hormone receptor	1
Increase, inositol triphosphate	1
Increase, leukocyte adherence	1
Increase, mucosal blood flow	1
Increase, mucous	1
Increase, myosin light chain phosphorylation	1
Increase, platelet aggregation	1
Increase, predation	1
Increase, pulmonate breathing	1
Increase, seizure	1
Increase, sex ratio (F/M)	1
Increase, surfactant	1
Increase, the risk of acute respiratory failure	1
Increase, vascular smooth muscle contraction	1
Increased (ectopic) all-trans retinoic acid concentration	1
Increased Ang II type 1 receptor (AT1R)	1
Increased CGRP, neuronal release of CGRP	1
Increased Homocysteine level	1
Increased LCN2/iron complex binds to SLC22A17 receptor in neuron	1
Increased Modified Proteins	1
Increased Respiratory irritability and Chronic Cough,	1
Increased Sodium-sensitive hypertension	1
Increased activity, beta-2 adrenergic receptor	1
Increased adipocyte numbers	1
Increased adipocyte size	1
Increased apoptosis, decreased fetal/adult Leydig Cells	1
Increased blood CCK level	1
Increased exocrine secretion from pancreatic acinar cells	1
Increased inflammatory immune responses	1
Increased intestinal monitor peptide level	1
Increased microRNA expression	1
Increased neurokinin A (NKA) by neuronal cells	1
Increased pro-inflammatory cytokine expression	1
Increased reactive oxygen species (in the mitochondria)	1
Increased sphingolipid-1-phosphate	1
Increased, 5-HT3 (5-hydroxytryptamine)	1
Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)	1
Increased, Appetite and hunger	1
Increased, Ataxia, paralysis, or hyperactivity	1
Increased, Atrioventricular block and bradycardia	1
Increased, Binding of chemicals to 2u (serum)	1
Increased, Catabolism of Muscle Protein	1
Increased, Cell Proliferation (mesothelium)	1
Increased, Cellular proliferation / hyperplasia of acinar cells	1
Increased, Chromosome misseggregation	1
Increased, Clearance of thyroxine from serum	1
Increased, DNA Damage-Repair	1
Increased, Deformed Wing Virus levels	1
Increased, Differentiation to Testis	1
Increased, Ductal Hyperplasia	1
Increased, Energetic demands and therefore metabolic stress	1
Increased, Expression of LXR activated genes	1
Increased, HIF-1 alpha transcription	1
Increased, HIF-1 heterodimer	1
Increased, Hyperplasia (glandular epithelial cells of endometrium)	1
Increased, Induction of pyruvate dehydrogenase (PDH)	1
Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts	1
Increased, Invasion	1
Increased, Kidney Failure	1
Increased, Kisspeptin signalling	1
Increased, LDL uptake	1
Increased, Leutinizing hormone (LH)	1
Increased, Liver Steatosis	1
Increased, Luteinizing hormone (LH)	1
Increased, Male Biased Sex Ratio	1
Increased, Male offspring	1
Increased, Motility	1
Increased, Oncotic Necrosis	1
Increased, Oocyte Atresia	1
Increased, Plasma HCY level	1
Increased, Plasma tyrosine	1
Increased, Proliferation (Endothelial cells)	1
Increased, Reproductive Success	1
Increased, Second Messenger Production	1
Increased, Steroidogenic acute regulatory protein (StAR)	1
Increased, Triglyceride formation	1
Increased, Triiodothyronine (T3) in tissues	1
Increased, activation of T (T) helper (h) type 2 cells	1
Increased, adipogenesis	1
Increased, blood potassium concentration	1
Increased, cardiac arrthymia	1
Increased, cholestasis	1
Increased, cyclic adenosine monophosphate	1
Increased, epilepsy	1
Increased, essential element imbalance	1
Increased, estrogens	1
Increased, extracellular matrix deposition	1
Increased, fibroblast proliferation and myofibroblast differentiation	1
Increased, foot detachment	1
Increased, gene expression of AR	1
Increased, glucocorticoid receptor activity	1
Increased, histomorphological alteration of testis	1
Increased, inflammation	1
Increased, intracellular chloride (Cl-)	1
Increased, intracellular serotonin	1
Increased, intracellular sodium (Na+)	1
Increased, lactotroph hyperplasia and hypertrophy	1
Increased, latency period	1
Increased, leukocyte activation	1
Increased, leukocyte adherence	1
Increased, oocyte maturation	1
Increased, packaged serotonin	1
Increased, prolactin exposure	1
Increased, prolactin secretion	1
Increased, seizure	1
Increased, synaptic release	1
Increased, tumor growth	1
Increases in cellular reactive oxygen species	1
Induced, dysfunction of microcirculation	1
Induction of GATA3 expression	1
Induction, Doublesex1 gene	1
Induction, IKB inhibitory protein	1
Induction, Liver “Dysfunctional” Changes by CGA 330050	1
Induction, Male reproductive tract	1
Induction, Microvesicular fat	1
Induction, Sustained Cell Proliferation	1
Induction, Sustained Hepatotoxicity	1
Induction, Upregulation of glucuronyltransferase activity	1
Induction, persistent proliferation/sustained proliferation	1
Induction, pharyngeal muscle paralysis	1
Influenza A Virus (IAV) binds sialic acid glycan receptor	1
Influenza A Virus (IAV) budding	1
Influenza A Virus production increased	1
Influenza A virus (IAV) cell entry	1
Inhibition GABAA receptor	1
Inhibition VEGF/VEGFR pathway	1
Inhibition of 11β-HSD	1
Inhibition of ALDH1A (RALDH)	1
Inhibition of Fyna	1
Inhibition of JAK3	1
Inhibition of N-linked glycosylation	1
Inhibition of N-type Ca ion channels	1
Inhibition of Plxna2	1
Inhibition of Sulfotransferase E1 (SULT1E1)	1
Inhibition of cystathionine beta-synthase	1
Inhibition of lysyl oxidase	1
Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)	1
Inhibition of rapid delayed rectifying potassium current	1
Inhibition of tyrosinase	1
Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme	1
Inhibition, 5α-reductase	1
Inhibition, 5α-reductase activity	1
Inhibition, Activin signaling	1
Inhibition, Bile Salt Export Pump (ABCB11)	1
Inhibition, Ca++ ATPase	1
Inhibition, Calcineurin Activity	1
Inhibition, Chitin synthase 1	1
Inhibition, Chitinase	1
Inhibition, Chitobiase	1
Inhibition, Cyclooxygenase 1 activity	1
Inhibition, Deiodinase 3	1
Inhibition, Dual oxidase	1
Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel	1
Inhibition, Fatty Acid Beta Oxidation	1
Inhibition, Fin regeneration	1
Inhibition, HMG-CoA reductase	1
Inhibition, IKK complex	1
Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307	1
Inhibition, PPAR alpha	1
Inhibition, Pendrin	1
Inhibition, Prolyl hydroxylases	1
Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme	1
Inhibition, UROD	1
Inhibition, VegfR2	1
Inhibition, Wnt pathway	1
Inhibition, organic anion transporter 1 (OAT1)	1
Insufficiency, Vascular	1
Interaction of α-diketones with arginine residues	1
Interference, nuclear localization of NFAT	1
Interferon-I antiviral response, antagonized by SARS-CoV-2	1
Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone	1
KE1 : S-Glutathionylation, eNOS	1
KE2 : Decrease, GTPCH-1	1
KE3 : Decrease, Tetrahydrobiopterin	1
KE5 : Decrease, AKT/eNOS activity	1
KE6 : Depletion, Nitric Oxide	1
KE7 : Impaired, Vasodilation	1
KE8 : Increase, Vascular Resistance	1
Latent Transforming growth Factor beta expression	1
Locomotor activity, decreased	1
Loss of drebrin	1
Malformation, Male reproductive tract	1
Metabolism of AFB1, Production of Reactive Electrophiles	1
Mitochondrial Complex IV inhibition	1
Mitochondrial Complex V inhibition	1
Mitochondrial Injury	1
Mitochondrial dysfunction EMPTY	1
Motile Cilia Number/Length, Decreased	1
Mu Opioid Receptor Agonism	1
Mucociliary Clearance, Decreased	1
N/A, Ataxia, paralysis, or hyperactivity	1
N/A, Gap	1
N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects	1
N/A, Liver Steatosis	1
N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	1
N/A, hypoxia	1
N/A, sedation	1
NLRP3 inflammasome activity, increased	1
Necrotic Tissue	1
Neuronal dysfunction	1
Neutrophil activation, Increased	1
Not Increased, Circulating Ketone Bodies	1
Notochord distortion or malformations	1
Occurrence, A paroxysmal depolarizing shift	1
Occurrence, Focal Seizure	1
Occurrence, Kidney toxicity	1
Occurrence, cardiac arrhythmia	1
Occurrence, renal ischemia	1
Occurrence, tophi (urate) deposition	1
Olfactory epithelium degeneration	1
Opening of G protein gated inward rectifying K channels	1
Opening of calcium channel, Calcium influx	1
Opening, voltage-gated calcium channels	1
Overactivation, Neuronotransmitter release	1
Overactivation, muscle contraction	1
Overexpression of rasl11b	1
Overwhelmed, Mitochondrial DNA repair mechanisms	1
Oxidation of membrane lipids	1
Oxidation, Glutathione (To be considered with MIE)	1
Oxidation, Uroporphyrinogen	1
Oxidation/denatuation of membrane proteins	1
Parkinsonian motor deficits	1
Perturbation of cholesterol	1
Pin-1 activation	1
Platelet activation, Increased	1
Platelet-neutrophil interactions, Increased	1
Porcupine-induced Wnt secretion and Wnt signaling activation	1
Premature cell differentiation	1
Production, Critical Metabolites (CGA 330050 and CGA 265307)	1
Production, Reactive oxygen species	1
Proliferation, Cell proliferation in the absence of cytotoxicity	1
Proliferation/Clonal Expansion, aberrant basal cells	1
Proliferation/Clonal Expansion, smooth muscle	1
Prolongation of Action Potential Duration	1
Prolongation of QT interval	1
Promotion, SIX-1 postive basal-type progenitor cells	1
Promotion, ovarian adenomas	1
Protein Adduct Formation	1
Pulmonary inflammation	1
ROS formation	1
Reduce expression, BDNF (Brain-derived neurotrophic factor)	1
Reduced complex sphingolipids	1
Reduced cortical thickness	1
Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction	1
Reduced number of oligodendrocytes	1
Reduced size of the ovarian follicle pool	1
Reduced tidal volume	1
Reduced, Ability to attract spawning mates	1
Reduced, Anterior swim bladder inflation	1
Reduced, Antiseptic incorporated in food	1
Reduced, BDNF (Brain-derived neurotrophic factor)	1
Reduced, Brood care	1
Reduced, FXR activity	1
Reduced, Food storage	1
Reduced, GABA-A receptor activation	1
Reduced, Gonadotropin releasing hormone, hypothalamus	1
Reduced, HSD17B4 activity	1
Reduced, Hearing	1
Reduced, Luteinizing hormone (LH), plasma	1
Reduced, Maturation inducing steroid, plasma	1
Reduced, Meiotic prophase I/metaphase I transition, oocyte	1
Reduced, PPARalpha	1
Reduced, Pheromone release	1
Reduced, Presynaptic release of glutamate	1
Reduced, Prostaglandin E2 concentration, hypothalamus	1
Reduced, Prostaglandin F2alpha synthesis, ovary	1
Reduced, Prostaglandins, ovary	1
Reduced, Reproductive Success	1
Reduced, SHP activity	1
Reduced, Spawning behavior	1
Reduced, fatty acid beta oxidation	1
Reduced, mucosal defense	1
Reduced, platelet aggregation	1
Reduced, presynaptic neuron 2 activity	1
Reduction fo Pigmentation pattern	1
Reduction in melanin level	1
Reduction of L-Dopaquinone	1
Reduction of collagen crosslinking	1
Reduction of melanosome level	1
Reduction, 17-OH-pregnenolone conversion in DHEA	1
Reduction, 17-OH-progesterone conversion in androstenedione	1
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	1
Reduction, 17beta-estradiol synthesis by the undifferentiated gonad	1
Reduction, Angiogenesis	1
Reduction, Ca and HCO3 transport to shell gland	1
Reduction, Cholesterol transport in mitochondria	1
Reduction, Eggshell thickness	1
Reduction, Gonadotropins, circulating concentrations	1
Reduction, Ionotropic GABA receptor chloride channel conductance	1
Reduction, NFAT/AP-1 complex formation	1
Reduction, Neuronal synaptic inhibition	1
Reduction, Plasma progesterone concentration	1
Reduction, Progesterone synthesis	1
Reduction, Prostaglandin E2 concentration	1
Reduction, Testosterone synthesis by ovarian theca cells	1
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development	1
Reduction, Vitellogenin synthesis in liver	1
Reduction, fetal/adult testosterone	1
Reduction, progesterone uptake, decresed maturation	1
Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma	1
Repressed expression of steroidogenic enzymes	1
Repression of Gbx2 expression	1
Retinaldehyde dehydrogenase inhibition	1
Ryanodine receptor activation	1
SP (Substance P) release, Local increase of SP	1
Secondary genotoxicity	1
Serotonin 1A Receptor Agonism	1
Sexual behavior, decreased	1
Spermatocyte depletion	1
Stimulation, TLR7/8	1
Succinate dehydrogenase, inhibited	1
Superoxide generation, increased	1
Suppression of T cell activation	1
Suppression of IL-4 production	1
Suppression of STAT5 binding to cytokine gene promoters	1
Suppression, IL-2 and IL-4 production	1
Suppression, Immune system	1
Suppression, Inflammatory cytokines	1
Suppression, VLDL secretion	1
Synthesis, De Novo Fatty Acid (FA)	1
Systemic acute phase response	1
TRPA1 activation, TRPA1 Receptor	1
Th17 cell migration and inflammation induction	1
Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts	1
Toll Like Receptor (TLR) Dysregulation	1
Toll-like receptor 4 activation	1
Torsades de Pointes	1
Transcription of genes encoding acute phase proteins, Increased	1
Treat, carbamazepine	1
Trypsin inhibition	1
Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis	1
Unknown, MIE	1
Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)	1
Up Regulation, CYP1A1	1
Up Regulation, FAS	1
Up Regulation, LDLR (low density lipoprotein receptor)	1
Up Regulation, SREBF2	1
Up Regulation, Unsaturated fatty acid	1
Upregulated, Spindle assembly checkpoint protein Mad2-oocyte	1
Urothelial cell injury/death	1
Vascular barrier disruption	1
Weak collagen matrix	1
Weak, Procuticle protection	1
Weakened, Colony	1
abnormal, placental labyrinth vasculature morphology	1
altered, inner ear development	1
beta-catenin activation	1
chronic high fat diet	1
decline, neural progenitor cells	1
decrease, transcription of genes by AR	1
decreased dopamine	1
decreased folate uptake	1
decreased oocyte maturation	1
decreased, Bcl-2 expression	1
decreased, Intellectual Quotient	1
eya1 expression, inhibited	1
foxi1 expression, increased	1
hERG channel blockade	1
impaired, Development	1
impaired, Larval development	1
impaired, Learning and memory	1
impaired, ion channels	1
increase, placental insufficiency	1
increased MyD88 activation	1
increased adipogenesis	1
increased lipid accumulation	1
increased mantel display	1
increased, Bax expression	1
induced spawning	1
inhibition, EKR1/2 signaling pathway	1
interruption, Ovulation	1
irregularities, ovarian cycle	1
malformed, Male reproductive tract	1
modulation, Unknown	1
modulation, sodium channel	1
narcosis	1
prepubertal increase, Estrogen receptor (ER) activity	1
prolonged, Depolarization of neuronal membrane	1
prolonged, elevation of serun CCK	1
prostatic intraepithelial neoplasia	1
reduced dimerization, ARNT/HIF1-alpha	1
reduction in ovarian granulosa cells, Aromatase (Cyp19a1)	1
relaxation, smooth muscle	1
six1b expression, increased	1
squamous metaplasia, aberrant basal cells	1
stabilization, PPAR alpha co-repressor	1
systemic inflammation leading to hepatic steatosis	1

Code examples

curl

curl -s https://raw.githubusercontent.com/h2020-sbd4nano/sbd-data-book/master/sparql/relationshipsByCause.rq | sed 's+<lang/>+en+' > relationshipsByCause.rq

curl -H "Accept: text/tab-separated-values" -G https://sbd4nanolandscape.rdf.bigcat-bioinformatics.org/sparql --data-urlencode query@relationshipsByCause.rq

This SPARQL query is available under CCZero.