sbd-data-book

relationshipsByOutcome.rq

Code examples: curl

SPARQL

PREFIX sbd:     <https://www.sbd4nano.eu/rdf/#>
PREFIX sbdbel:  <https://www.sbd4nano.eu/bel/#>
PREFIX dc:      <http://purl.org/dc/elements/1.1/>
PREFIX dcterms: <http://purl.org/dc/terms/>
PREFIX sbdbel2:  <https://h2020-sbd4nano.github.io/sbdbel/>

SELECT ?outcome (COUNT(DISTINCT ?relation) AS ?count)
WHERE {
  VALUES ?ca { sbdbel:CausalAssertion sbd:CausalAssertion sbdbel2:CausalAssertion }
  ?relation a ?ca ;
    sbdbel:outcome / rdfs:label ?outcome .
} GROUP BY ?outcome
  ORDER BY DESC(?count)

run

Output

outcome	count
Mitochondrial dysfunction	23
Impairment, Learning and memory	18
Decrease, Population growth rate	17
Cell injury/death	17
Increased Mortality	16
toxicity	16
Increased, Reactive oxygen species	15
cell uptake (amount)	15
increased，Vascular endothelial dysfunction	14
Apoptosis	13
impaired, Fertility	10
ROS production	10
Increase, Apoptosis	9
Increase, Mortality	9
Increased, secretion of proinflammatory mediators	9
Decrease of neuronal network function	9
Increased, Liver Steatosis	9
Increased, Oxidative Stress	8
Oxidative Stress	8
Increase, Mutations	8
Neuroinflammation	8
Accumulation, Fatty acid	8
Increase, Oocyte apoptosis	7
N/A, Neurodegeneration	7
Decrease, Reproduction	7
protein corona	7
Decrease, Lung function	6
Epithelial Mesenchymal Transition	6
Increase, Inflammation	6
Decrease, Adenosine triphosphate pool	6
Cognitive Function, Decreased	6
Increase, Cell death	6
Occurrence, Kidney toxicity	6
Increase, Cell Proliferation	6
Increase, Oxidative Stress	6
dissolution	6
Thyroid hormone synthesis, Decreased	6
Thyroxine (T4) in serum, Decreased	6
Accumulation, Triglyceride	6
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	6
Weakened, Colony	5
Decrease, Oogenesis	5
Activated, gastric ulcer formation	5
Altered, Gene Expression	5
Increased, glutamate	5
Tissue resident cell activation	5
Decrease, Growth	5
Inadequate DNA repair	5
Increase, Endothelial Dysfunction	5
Decrease of synaptogenesis	5
Decreased spermatogenesis	5
Increase in inflammation	5
Decrease of egg production and cummulative fecundity	5
Occurrence of Cataracts	5
Synthesis, De Novo Fatty Acid (FA)	5
Up Regulation, CD36	5
cell viability	5
aggregation	5
cytotoxicity	5
concentration	5
cell uptake (type)	5
impaired, Learning and memory	5
Accumulation, Collagen	5
Increase, hepatocellular adenomas and carcinomas	5
Altered, Cardiovascular development/function	5
Decreased, Reproductive Success	4
Occurrence, renal proximal tubular necrosis	4
Altered, Amphibian metamorphosis	4
Reduced, Swimming performance	4
Increased, secretion of local growth factors	4
Activate, mucosal defense	4
Reduced, mucosal defense	4
Increase, Cell Proliferation (Epithelial Cells)	4
Increase, DNA damage	4
Increased, Invasion	4
decreased dopamine	4
Increase, DNA double-strand breaks	4
Increased Pro-inflammatory mediators	4
Unfolded Protein Response	4
General Apoptosis	4
Increase, Cell membrane depolarization	4
Decrease in mitochondrial oxidative phosphorylation	4
Increase, lung cancer	4
Facial cartilage structures are reduced in size and morphologically distorted	4
Decrease, dihydrotestosterone (DHT) level	4
Decrease, androgen receptor activation	4
metastatic breast cancer	4
Inhibition, Nuclear factor kappa B (NF-kB)	4
Overactivation, NMDARs	4
Increased, Intracellular Calcium overload	4
Respiratory distress/arrest	4
Decreased, Mitochondrial fatty acid beta-oxidation	4
Decrease, Cell proliferation	4
Induction, Microvesicular fat	4
Formation, Mallory body	4
Increase, DNA strand breaks	4
anogenital distance (AGD), decreased	4
Decrease, testosterone levels	4
Altered Bone Cell Homeostasis	4
Increase, Abnormal Neural Remodeling	4
Reduction, Plasma 17beta-estradiol concentrations	4
Alterations, Cellular proliferation / hyperplasia	4
Release, Cytokine	4
Increase risk, microcephaly	4
Increased, De Novo FA synthesis	4
Up Regulation, SCD-1	4
Abnormal, Foraging activity and behavior	4
Death/Failure, Colony	4
Increased, predation	4
Increase, Incomplete ecdysis	4
photo-reactivity	4
size	4
Altered, Meiotic chromosome dynamics	4
Hippocampal Physiology, Altered	4
Reduced number of oligodendrocytes	4
Decreased, Neuronal network function in adult brain	4
Reduced, Reproductive Success	4
Increase, Cytotoxicity (renal tubular cell)	4
Increase, cell proliferation (hepatocytes)	4
Increased, valve movement	3
Depletion, energy reserves	3
Increased, circulating estrogen levels	3
Increased, Adenomas/carcinomas (mammary)	3
Decreased, Triiodothyronine (T3)	3
Reduced, Posterior swim bladder inflation	3
Inhibition, Feeding	3
Inhibit, gastric ulcer formation	3
Increase, angiogenesis	3
Locomotor activity, decreased	3
Liver Cancer	3
Decreased, HSD17B10 expression	3
Increased activation, Nuclear factor kappa B (NF-kB)	3
Increased Respiratory irritability and Chronic Cough,	3
induced spawning	3
Induced parturition	3
Increased, Lipid peroxidation	3
obesity	3
Systemic acute phase response	3
Reproductive failure	3
Activation, TGF-beta pathway	3
Reduced, BDNF (Brain-derived neurotrophic factor)	3
Increased, seizure	3
Decrease, Oxidative phosphorylation	3
Increased, recruitment of inflammatory cells	3
Increased, extracellular matrix deposition	3
Cell cycle, disrupted	3
Oxidative Stress in Brain	3
N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	3
Increased Angiotensin II	3
Decreased, plasma 11-ketotestosterone level	3
Impaired, Spermatogenesis	3
Decrease, Mitochondrial membrane potential	3
Cholestasis, Pathology	3
Decrease, Cardiac contractility	3
Liver Injury	3
Neural tube defects	3
Impaired axonial transport	3
Proteasomal dysfunction	3
Inflamatory events in light-exposed tissues	3
Accumulation of misfolded proteins	3
Increase in reactive oxygen and nitrogen species (RONS)	3
Chronic obstructive pulmonary disease	3
Activation of inflammation pathway	3
Increase, developmental abnormalities	3
Altered, Nitric Oxide Levels	3
Tumorigenesis, Hepatocellular carcinoma	3
Reduced levels of BDNF	3
Activation, Dendritic Cells	3
Decrease, Mitochondrial ATP production	3
irregularities, ovarian cycle	3
Reduction, Testosterone synthesis in Leydig cells	3
Inhibition, Mitochondrial fatty acid beta-oxidation	3
Increased, Triglyceride formation	3
Increased, Differentiation to Testis	3
Increased, Male Biased Sex Ratio	3
Altered, Thyroid hormone-dependent gene expression	3
Hyperinflammation	3
impaired olfactory function (anosmia)	3
Increased, Chloride conductance	3
Reduction, Cumulative fecundity and spawning	3
Decreased, Glomerular filtration	3
Decreased, Renal plasma flow	3
Decreased, Sodium reabsorption	3
Decreased, Renal ability to dilute urine	3
Occurrence, Cytoplasmic vacuolization (hepatocyte)	3
Occurrence, Ballooning degeneration (hepatocyte)	3
Occurrence, Cytoplasmic vacuolization (Bile duct cell)	3
Occurrence, Cytoplasmic vacuolization (kupffer cell)	3
Increase, Oxidative damage to DNA	3
Increase, Chromosomal aberrations	3
Altered, Visual function	3
Increased, DNA damage and mutation	3
Insulin resistance, increased	3
Increased fat mass	3
Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma	3
Neurological disorder	3
Increase, Vascular disrupting effects	3
Activation, caspases	3
Increase, Cancer	3
Degeneration of dopaminergic neurons of the nigrostriatal pathway	3
Parkinsonian motor deficits	3
KE4 : Uncoupling, eNOS	3
Increase, Early Life Stage Mortality	3
Cilia Beat Frequency, Decreased	3
Synaptic dysfunction	3
Activation, SREBF1	3
Decrease, Number of worker bees	3
Increased, Clearance of thyroxine from serum	3
Hippocampal gene expression, Altered	3
Increased, Kidney Failure	3
Reduction, Plasma vitellogenin concentrations	3
Increase, Reactive Oxygen Species production	3
Activation, Stellate cells	3
Reduction, Vitellogenin synthesis in liver	3
Altered, Transcription of genes by the androgen receptor	3
Induction, Upregulation of glucuronyltransferase activity	3
Increase, predation	3
Increased, secretion of GnRH from hypothalamus	2
Hyperplasia, ovarian stromal cells	2
Hyperplasia, ovarian epithelium	2
Decrease, E2 blood concentrations at hypothalamus	2
Increased, cholestasis	2
Alteration, lipid metabolism	2
Decreased, Triiodothyronine (T3) in tissues	2
Increased, Hepatic thyroid hormone uptake/transport	2
Increased, oocyte maturation	2
Hyperplasia, Mammary gland	2
Increased, latency period	2
Increased, mesotheliomas	2
Increased, blood uric acid concentration	2
Impairment, Endothelial network	2
Reduced, Anterior swim bladder inflation	2
Increased, Neuronal synaptic inhibition	2
Increased, Thyroid-stimulating hormone (TSH)	2
Activation of specific nuclear receptors, PPAR-gamma activation	2
Decrease, surfactant	2
N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects	2
Sexual behavior, decreased	2
Hepatocytotoxicity	2
Increased, Reproductive Success	2
Decreased, Apoptosis (Epithelial Cells)	2
Increased, ER binding to T.F. to DNA (non-classical pathway)	2
Increased, Non-genomic signaling	2
Increased, Ductal Hyperplasia	2
N/A, Breast Cancer	2
Acetylcholinesterase (AchE) Inhibition	2
Increased, Angiogenesis	2
Increased, Motility	2
Altered, Ca2+-calmodulin activated signal transduction	2
increased mantel display	2
Atherosclerosis	2
Increase, Follicular atresia	2
increased adipogenesis	2
Pulmonary fibrosis	2
Reduced, GABA-A receptor activation	2
Release of G Proteins	2
Analgesia	2
Anti-depressant Activity	2
Transcription of genes encoding acute phase proteins, Increased	2
Lung fibrosis	2
Perturbation of cholesterol	2
Hepatotoxicity	2
Activation, JNK	2
Increased, extracellular serotonin	2
Increased, intracellular sodium (Na+)	2
Increased, intracellular chloride (Cl-)	2
Decreased, neuroplasticity	2
Activation, 5-HT2A (Serotonin 2A)	2
Increase, intracellular calcium	2
Decreased, extracellular serotonin	2
Increase, seizure	2
Activated, membrane depolarization	2
Activate, GABA-A receptor	2
Increased, epilepsy	2
Increase, Reactive oxygen species	2
N/A, Liver fibrosis	2
Decrease, ATP production	2
Decrease, Photosynthesis	2
Decrease, Leaf development	2
Leukocyte recruitment/activation	2
Loss of alveolar capillary membrane integrity	2
Testicular atrophy	2
Spermatocyte depletion	2
Decrease, Cuticular chitin content	2
Increase, Premature molting	2
Impaired coordination and movement	2
Porcupine-induced Wnt secretion and Wnt signaling activation	2
Inhibition, Fin regeneration	2
Increase, Caspase transcription	2
Decrease, Oogenesis (F3)	2
Neural crest cell migration, reduced	2
Collagen production, reduced	2
Decreased Na/K ATPase activity	2
Sensory axonal peripheral neuropathy	2
Fibroproliferative airway lesions	2
Increase, Oxidative DNA damage	2
Decrease, testosterone synthesis/level	2
Impaired inguinoscrotal testicular descent phase	2
Increased microRNA expression	2
Decreased, Gonadotropins	2
Impaired, Reproduction	2
Secondary genotoxicity	2
Pulmonary inflammation	2
Emphysema	2
Airway remodeling	2
Endoplasmic reticulum stress	2
Decrease, sox9 expression	2
Decrease, palatal shelf outgrowth	2
Orofacial clefting	2
Weak, Procuticle protection	2
Altered Signaling Pathways	2
Occurrence, Vascular Remodeling	2
Loss of drebrin	2
Increased Modified Proteins	2
Increased Cholinergic Signaling	2
Decrease of Thyroidal iodide	2
Decreased, Population trajectory	2
Reduction, Cholesterol transport in mitochondria	2
Nipple retention (NR), increased	2
Latent Transforming growth Factor beta expression	2
Activation of ER stress	2
Apoptotic cell death	2
Displacement, Serum thyroxine (T4) from carrier protein	2
Encephalitis	2
Increased SARS-CoV-2 production	2
Increased Ang II type 1 receptor (AT1R)	2
Platelet-neutrophil interactions, Increased	2
Diminished protective oxidative stress response	2
hyperpolarisation, neuron	2
Increase, Cytotoxicity	2
Increase, Hyperplasia (glandular epithelial cells of endometrium)	2
Increase, Preneoplastic foci (hepatocytes)	2
Increase, Papillomas/carcinomas (squamous cells)	2
Increase, Regenerative cell proliferation (urothelial cells)	2
Increased, HIF-1 heterodimer	2
Decreased, cholesterol	2
Occurrence, Cytoplasmic vacuolization (Renal tubule)	2
Occurrence, Cystic dilatation (renal tubule)	2
Occurrence, Cytoplasmic vacuolization (podocyte)	2
Disturbance, Lysosomal function	2
Formation, Liver fibrosis	2
Altered, Photoreceptor patterning	2
Reduced tidal volume	2
Dysregulation of heart rate and vascular tone	2
Hypospadias, increased	2
Peptide Oxidation	2
Increase, Bone Remodeling	2
Occurrence, Bone Loss	2
Hypomyelination	2
Altered, cholesterol metabolism	2
prostatic intraepithelial neoplasia	2
Impaired insulin signaling	2
Activation, Dll4-Notch pathway	2
Decrease of GABAergic interneurons	2
Formation, Hepatocellular and Bile duct tumors	2
Decreased, Ketogenesis (production of ketone bodies)	2
Increase, Site of Contact Nasal Tumors	2
Disruption, Lysosome	2
KE6 : Depletion, Nitric Oxide	2
Decreased, Eye size	2
NLRP3 inflammasome activity, increased	2
Genomic instability	2
Intestinal barrier, disruption	2
Increased, estrogens	2
Increased, FA Influx	2
Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)	2
Abnormal, Roll change within caste	2
impaired, Larval development	2
impaired, Hive thermoregulation	2
Decreased, Sodium conductance 1	2
Increased, Free serum thyroxine (T4)	2
Increase, Mucin production	2
Impairment, T-cell dependent antibody response	2
Decrease, Digestion of old cuticle	2
Decreased, Population size	2
inflammasome activation	2
Toll-like receptors	2
NLRP3 expression	2
oxidative stress	2
mature IL-1β	2
environmental fate	2
charge	2
crystal structure	2
immunoproteasome LMP7	2
Increase, Hyperplasia (Leydig cells)	2
Increased, Estrogen receptor (ER) activity	2
Hippocampal anatomy, Altered	2
Increase, CNS Neural cell death	2
decline, neural progenitor cells	2
Decreased proliferation of cortical neural progenitor cells	2
Aberrant, synaptic formation and plasticity	2
Altered Liver X receptor activity	2
Feminisation or incomplete development, Primary and accessory male sex organs	2
Damaging, Red blood cells; hemolysis	2
Reduction, Testosterone synthesis by ovarian theca cells	2
reactivity	2
Reduced, survival	2
Increase, cilia movement	2
Increased, foot detachment	2
Increased, muscular waves in foot	2
Decreased, locomotion	2
Decreased, survival	2
Reduced, Prostaglandin F2alpha concentration, plasma	2
Reduced, Ability to attract spawning mates	2
Increase, Regenerative cell proliferation (tubular epithelial cells)	2
Increase, Adenomas/carcinomas (renal tubular)	2
Altered, Chromosome number	2
Alteration, Wnt pathway	2
Increase, Allergic Respiratory Hypersensitivity Response	2
Decrease, Fecundity	2
Increase, Heritable mutations in offspring	2
Increased, proliferation of mesenchymal cells	1
Increased, IGF-1 (mouse)	1
Increased, Firbrosarcoma	1
Increased, liposarcoma	1
Increased, hemagiosarcoma	1
Increased activity, beta-2 adrenergic receptor	1
relaxation, smooth muscle	1
Proliferation/Clonal Expansion, smooth muscle	1
Hypertrophy/hyperplasia, smooth muscle	1
Promotion, mesovarian leiomyomas	1
Increased, secrection of FSH from anterior pituitary	1
Increased, secretion of LH from anterior pituitary	1
Promotion, ovarian adenomas	1
Promotion, ovarian granular cell tumors	1
Decreased, bile flow	1
Reduction, Eggshell thickness	1
prolonged, elevation of serun CCK	1
Increased, Cellular proliferation / hyperplasia of acinar cells	1
Increased, Pancreatic acinar tumors	1
Activation, estrogen receptor alpha	1
Promotion, SIX-1 postive basal-type progenitor cells	1
Antagonism, Estrogen receptor	1
Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis	1
Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage)	1
Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)	1
Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal	1
Hemostasis, Depletion from blood of fully functional carboxylated clotting factors	1
Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction	1
Impaired recruitment , Population trajectory	1
Increased, water retention in foot	1
Increase, FA Influx	1
Increased, Triiodothyronine (T3) in tissues	1
Activation, FAS	1
Proliferation/Clonal Expansion, aberrant basal cells	1
squamous metaplasia, aberrant basal cells	1
Increased, Hyperplasia (glandular epithelial cells of endometrium)	1
Increased, adenosquamous carcinomas of endometrium	1
Decreased, LH Surge from anterior pituitary	1
interruption, Ovulation	1
prolonged, estrus	1
Increased, prolactin exposure	1
Increased, lactotroph hyperplasia and hypertrophy	1
Increased, adenomas (pituitary)	1
Increased, prolactin secretion	1
Increased, hyperplasia (mammary gland)	1
Increased, inflammation	1
Increased, Cell Proliferation (mesothelium)	1
Increased, blood potassium concentration	1
Occurrence, tophi (urate) deposition	1
Decreased, Prostaglandin F2alpha concentration, plasma	1
Occurrence, renal ischemia	1
Occurrence, cardiac arrhythmia	1
Abnormal, Role change within caste	1
Acetylcholine accumulation in synapses	1
stabilization, PPAR alpha co-repressor	1
Increased, Developmental Defects	1
Reduced, Hearing	1
Increased, Inhibitory postsynaptic potential	1
Induction, Somatic muscle paralysis	1
Activation, Glutamate-gated chloride channels	1
Induction, pharyngeal muscle paralysis	1
Increased, adipogenesis	1
Increase, bicarbonate	1
Increase, mucous	1
Increase, mucosal blood flow	1
Increase, platelet aggregation	1
Decrease, leukocyte adherence	1
Activate, leukocyte	1
Increase, ammonium (NH4+)	1
7α-hydroxypregnenolone synthesis in the brain, decreased	1
Dopamine release in the brain, decreased	1
Activation of Cyp2E1	1
Induction, persistent proliferation/sustained proliferation	1
Increased, intracellular serotonin	1
Increased, packaged serotonin	1
Increased, synaptic release	1
Decreased, 5-HT3	1
Reduced, platelet aggregation	1
Decreased, mucosal blood flow	1
Decreased, mucous	1
Increased, Population	1
Increase, Phenotypic enzyme activity	1
Increase, Clonal Expansion of Altered Hepatic Foci	1
Decreased, sodium conductance 2	1
Decreased, Ionotropic GABA receptor chloride channel conductance	1
Decreased, GABA release	1
Formation, Formation of hemoglobin adducts	1
Increased, ER binding to DNA (classical pathway)	1
Increased, Proliferation (Endothelial cells)	1
N/A, Gap	1
Increased, Migration (Endothelial Cells)	1
Suppression, IL-2 and IL-4 production	1
Induction, Doublesex1 gene	1
Increased, Male offspring	1
Induction, Male reproductive tract	1
Alteration, Food-web structures	1
Altered gene expression specific to CAR activation, Hepatocytes	1
Opening of calcium channel, Calcium influx	1
Activation, Glucocorticoid Receptor	1
Trigeminal nerve activation	1
SP (Substance P) release, Local increase of SP	1
Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea	1
Altered, Protein Production	1
Increased, Second Messenger Production	1
MLL chromosomal translocation	1
Infant leukaemia	1
Necrosis	1
Increase, Nuclear receptor E75b gene expression	1
Increase, Fushi tarazu factor-1 gene expression	1
Decrease, Circulating crustacean cardioactive peptide	1
Induction, IKB inhibitory protein	1
decreased reward	1
decreased DNA methylation of tyrosine hydroxylase	1
decreased methylation of dopamine transporter promoter	1
Increase, Differentiation of fibroblasts	1
Inhibition of lysyl oxidase	1
Decreased, bicarbonate	1
Decreased, angiogenesis	1
Increased, leukocyte adherence	1
Increased, leukocyte activation	1
Decreased, GABA	1
Decreased, intracellular chloride	1
Reduced, FXR activity	1
Hyperplasia, Hyperplasia	1
Reduced, SHP activity	1
Activated, LXR	1
Reduced, PPARalpha	1
Reduced, HSD17B4 activity	1
Reduced, fatty acid beta oxidation	1
Opening of G protein gated inward rectifying K channels	1
Inhibition of N-type Ca ion channels	1
Inhibition of neurotransmitter vesicle release	1
Increased CGRP, neuronal release of CGRP	1
Irritation of nasal mucosa inducing sneeze reflex	1
Increased neurokinin A (NKA) by neuronal cells	1
Decrease, Ecdysis motoneuron bursts	1
Decrease, Excitatory postsynaptic potential	1
Increase, COX-2 expression	1
Activation of TGF-β signaling	1
Collagen Deposition	1
ROS formation	1
Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	1
Activation, HIF-1	1
Increased, DNA Damage-Repair	1
Up Regulation, Unsaturated fatty acid	1
Glutathione synthesis	1
Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene	1
Reduction, Gonadotropins, circulating concentrations	1
Glutathione homeostasis	1
Activation, FOXO	1
Inhibition, Wnt pathway	1
Defect of Embryogenesis	1
Depletion, GSH	1
Increase, cytosolic fatty acid	1
Down Regulation, Gulcose-6-phosphate dehydrogenase	1
Decreased, extracellular sodium (Na+)	1
Decreased, extracellular chloride (Cl-)	1
Decreased, intracellular serotonin	1
Decreased, packaged serotonin	1
Decreased, synaptic release	1
Increased, 5-HT3 (5-hydroxytryptamine)	1
Inactivated, 5-HTR (serotonin receptors)	1
Reduce expression, BDNF (Brain-derived neurotrophic factor)	1
Activate, PLC (Phospholipase C)	1
Increase, inositol triphosphate	1
Activate, calmodulin	1
Increase, myosin light chain phosphorylation	1
Increase, vascular smooth muscle contraction	1
Increase, hypertension	1
Increased, agitation	1
Increased, depression	1
Activated, NMDA receptor	1
Activated, voltage-gated sodium channel	1
Binding to voltage-gated sodium channel	1
Inactive, membrane depolarization	1
Increase, GABA	1
Increased, hippocampal hyperdepolarization	1
N/A, Impairment of reproductive capacity	1
Altered, Larval development	1
N/A, Liver Steatosis	1
Formation, Liver tumor	1
Malformation, Male reproductive tract	1
Reduction of collagen crosslinking	1
Weak collagen matrix	1
Notochord distortion or malformations	1
Growth, reduction	1
Activation, Transforming Growth Factor beta pathway	1
Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307	1
Decrease, Chlorophyll synthesis	1
Decrease, Light harvest capacity	1
Decrease, Glycolysis	1
Decrease, Leaf cell mitosis	1
Depletion, mtDNA	1
Glutamate dyshomeostasis	1
N/A, Steatohepatisis	1
Increased, Oncotic Necrosis	1
Increased, activation of T (T) helper (h) type 2 cells	1
Increased, fibroblast proliferation and myofibroblast differentiation	1
Histone deacetylase inhibition	1
Histone acetylation, increase	1
Protein Adduct Formation	1
Lipid Peroxidation	1
Neurodegeneration	1
Suppression, Inflammatory cytokines	1
Increase, Opening of voltage-dependent calcium channel	1
Fatty Acid Beta Oxidation, Decreased	1
Decrease, Calcium currents	1
Decrease, Calcium binding to Troponin C	1
Increase, IL-23 from matured dendritic cells	1
Th17 cell migration and inflammation induction	1
Psoriatic skin disease	1
Induction of GATA3 expression	1
Increase of Th2 cells producing IL-4	1
Increase of anti-DNA antibody from autoreactive B cell	1
Exacerbation of systemic lupus erythematosus (SLE)	1
Blockade of STAT5 phosphorylation	1
Suppression of STAT5 binding to cytokine gene promoters	1
Suppression of IL-4 production	1
Impairment of T-cell dependent antibody response	1
Increased intestinal monitor peptide level	1
Increased blood CCK level	1
Increased exocrine secretion from pancreatic acinar cells	1
Acinar cell proliferation	1
Pancreatic acinar cell tumors	1
SARS-CoV-2 cell entry	1
Increase plasma Ang II	1
Increase, the risk of acute respiratory failure	1
Increased inflammatory immune responses	1
beta-catenin activation	1
Reduce, Sperm count	1
Increase, Cripto-1 expression	1
Inhibition, Activin signaling	1
Urothelial cell injury/death	1
Urothelial Tumor	1
Increase, Protein oxidation	1
Increase, Abnormal osmoregulation	1
Increase, Body fluid overload	1
Decrease, Neutral lipids	1
Decrease, Global DNA methylation	1
Increase, Ovarian somatic cell apoptosis	1
Increase, Ovarian follicle breakdown	1
Decrease, Heritable DNA methylation (F3)	1
Increase, Caspase transcription (F3)	1
Disruption, Mitochondrial electron transport chain	1
Increase, Oocyte apoptosis (F3)	1
Decrease, Fecundity (F3)	1
Increase, Ovarian somatic cell apoptosis (F3)	1
Increase, Ovarian follicle breakdown (F3)	1
Increased, Oxidative damage	1
Decrease, Cardiac ejection fraction	1
Heart failure	1
Disruption, Intracellular calcium mobilization	1
Disruption, Sarcomere assembly	1
Decreased protection against oxidative stress	1
Increase, Mitochondrial complex III antagonism	1
Mitochondrial Complex IV inhibition	1
Mitochondrial Complex V inhibition	1
Increased reactive oxygen species (in the mitochondria)	1
Mitochondrial Injury	1
Necrotic Tissue	1
Increase Chromosomal Aberrations	1
Altered differentiation	1
Decreased proximal tubular vectorial transport	1
Chemical induced Fanconi syndrome	1
Activation, Caspase 8 pathway	1
Activation, Tissue resident cells (Kuppfer cells)	1
Increase, proinflammatory mediators (TNFalpha)	1
Disturbance in microtubule dynamic instability	1
Airway epithelial injury	1
Bronchiolitis obliterans	1
Oxidation of membrane lipids	1
Oxidation/denatuation of membrane proteins	1
Activation, Muscarinic Acetylcholine Receptors	1
Chronic kidney disease	1
Activation of hepatic stellate cells	1
Increase, Necrosis	1
Increase, Liver and splenic hemosiderosis	1
Reduction, 17-OH-pregnenolone conversion in DHEA	1
Reduction, 17-OH-progesterone conversion in androstenedione	1
Malformation, cryptorchidism - maldescended testis	1
Occurrence, Focal Seizure	1
Reduction of L-Dopaquinone	1
Reduction in melanin level	1
Reduction of melanosome level	1
Reduction fo Pigmentation pattern	1
Premature cell differentiation	1
Decreased SIRT1 expression	1
Disruption, action potential	1
Increased, Kisspeptin signalling	1
Decreased, Androgen and Progestin	1
Decreased, Maturation Inducing Steroid Surge by Granulosa cells	1
Impaired, Oocyte maturation and ovulation	1
Increased, Oocyte Atresia	1
Activation, Microglia	1
Fibroblast proliferation and differentiation	1
Increase, slincR expression	1
Reduced complex sphingolipids	1
Affected folate transporter	1
decreased folate uptake	1
Decrease, GLI1/2 translocation to nucleus	1
Increased sphingolipid-1-phosphate	1
Inositol triphosphate receptor activation	1
Activation of calpain signalling	1
Decrease, GLI1/2 target gene expression	1
Decrease, Sonic Hedgehog second messenger production	1
Decrease, Smoothend relocation and activation	1
Increase, Vitellogenin mRNA	1
Delay, Ovarian maturation	1
Increase, Body volume of female adults	1
Increase, sex ratio (F/M)	1
Decrease, dopa decarboxylase	1
Increase, Defects in tanning of new cuticle	1
Increase, impairment of cuticle sclerotization	1
Increase, pigmentation	1
Increase, delay in oviposition	1
Decrease, hatching of egg	1
Decrease, knickkopf gene	1
Decrease, Chitin laminar organization	1
Decrease, Prevent chitin degradation by chitinases	1
Decrease, New cuticle secretion	1
Increase, Cytosolic calcium	1
Increase, Glycolysis	1
Decrease, Glucose pool	1
Increase, Mitochondrial swelling	1
increase oxidation of the di-copper moiety of the hemocyanin active site	1
Decreased, oxygen binding capacity by hemocyanin	1
Cognitive, sensed as hypoxic/low oxygen environment	1
Increase, hemocyanin mRNA	1
Increase, pulmonate breathing	1
Decline, Population	1
Altered, Reproductive behaviour	1
Impaired development of, Reproductive organs	1
Uroporphyria	1
Formation, Pro-mutagenic DNA Adducts	1
Increased, Induced Mutations in Critical Genes	1
Aberrant, Dendritic morphology	1
Reduced, Presynaptic release of glutamate	1
Suppression, Immune system	1
Increase, Luteinizing hormone (LH)	1
Hyperplasia, Leydig cell	1
Increase proliferation, Leydig cell	1
Increased, Atrioventricular block and bradycardia	1
Reduction, fetal/adult testosterone	1
Suppression, VLDL secretion	1
Downregulation, ACE2	1
Status epilepticus	1
Reduction, 17beta-estradiol synthesis by the undifferentiated gonad	1
Activator protein 1 activation	1
Pin-1 activation	1
Granulosa cell proliferation of gonadotropin-independent follicles, Reduced	1
Increase, Cytochrome c release	1
Immune cell activation	1
IFNγ signaling	1
Immune mediated hepatitis	1
Increase, Global DNA methylation	1
Increased, Thyroxine (T4) in serum	1
Decrease, Acyl-CoA dehydrogenases	1
Cortisol and 11β-(OH) testosterone decreased	1
Decreased plasma Cortisol level	1
decreased oocyte maturation	1
Coagulation	1
Thrombosis and Disseminated Intravascular Coagulation	1
Toll Like Receptor (TLR) Dysregulation	1
Impaired gustatory nerve	1
dysgeusia	1
Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)	1
Dysregulation, ACE2 expression and activity	1
Increased Sodium-sensitive hypertension	1
Imbalanced salty and sweet taste responses	1
Increase, D1 protein deactivation	1
Decrease, Photosystem II efficiency	1
Increase, Programmed cell death	1
Fibrinolysis, decreased	1
Bradykinin system, hyperactivated	1
Sustentacular cells, decrease	1
olfactory sensory neurons, decrease	1
Olfactory epithelium degeneration	1
N/A, Ataxia, paralysis, or hyperactivity	1
Decreased, population 1	1
Increase, Hyperplasia (renal tubular cells)	1
Increase, Oxidative metabolism	1
Increase, Endometrial adenocarcinomas	1
Increased, Plasma tyrosine	1
Increase, Cytotoxicity (corneal cells)	1
Increase, Inflammation (corneal cells)	1
Increase, Regenerative cell proliferation (corneal cells)	1
Increase, Cytotoxicity (epithelial cells)	1
Increase, Regenerative cell proliferation (forestomach epithelial cells)	1
Increase, Hyperplasia (forestomach epithelial cells)	1
Increase, Hyperplasia (tubular epithelial cells)	1
Increase, Regenerative cell proliferation (hepatocytes)	1
Increased, Leutinizing hormone (LH)	1
Decrease, Bioactivation of testosterone	1
Increase, Cytotoxicity (urothelial cells)	1
Increase, Hyperplasia (urothelial)	1
Increase, Adenomas/carcinomas (urothelial)	1
Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity	1
Up Regulation, CYP1A1	1
Decreased, Aromatase (Cyp19a1) mRNA	1
Increased, HIF-1 alpha transcription	1
Decreased, mevalonate	1
malformed, Male reproductive tract	1
Increased, Serum creatinine	1
Activation, Keratinocytes	1
sensitisation, skin	1
Damage, Lipid bilayer	1
Oxidation, Uroporphyrinogen	1
Induction, Liver “Dysfunctional” Changes by CGA 330050	1
Decreased retinoic acid (RA) synthesis	1
Decreased plasma RA level	1
Treatment-resistant gastric cancer	1
Antagonism, Thyroid Receptor	1
Decreased, Long-term potentiation (LTP)	1
Increased Homocysteine level	1
Increased, Plasma HCY level	1
Induced, dysfunction of microcirculation	1
Impaired,anterior-posterior axis development	1
Activation, LXR	1
Lung cancer	1
Inhibition of lung surfactant function	1
Alveolar collapse	1
Decreased, Lymphocytes	1
Disruption, Progenitor cells of second heart field	1
decrease, transcription of genes by AR	1
Reduction, Progesterone synthesis	1
Reduction, Plasma progesterone concentration	1
Reduction, progesterone uptake, decresed maturation	1
Impaired ovulation	1
Increase, DNA methyltransferase expression	1
Increase, hypermethylation of the promotor region of gonadotropin releasing hormone receptor	1
Decrease, expression of gonadotropin releasing hormone receptor	1
Suppression of T cell activation	1
Promotion, Ovarian Cancer	1
Occurrence, (Micro)vascular dysfunction	1
Increase, Pro-Inflammatory Mediators	1
Altered regulation, Alpha hemoglobin	1
Inhibition of rapid delayed rectifying potassium current	1
Altered, white brain matter	1
Propagation, Oxidative stress	1
Increase, goblet cell number	1
Superoxide generation, increased	1
decreased, Intellectual Quotient	1
increased, socio-economic burden	1
decreased, Bcl-2 expression	1
increased, Bax expression	1
Increased adipocyte size	1
Increased adipocyte numbers	1
Metabolically unhealthy Obesity	1
increased lipid accumulation	1
Increased pro-inflammatory cytokine expression	1
Increase, Androgen receptor	1
Prostate cancer	1
Increase, Gonadotropins concentration in plasma	1
Bile accumulation, Pathological condition	1
Increased, gene expression of AR	1
Metabolic syndrome	1
Decreased, Viable Offspring	1
Increased intracelluar Iron accumulation	1
Disruption, neurotransmitter release	1
Epigenetic modification process	1
Expression of factors ruling proliferation, modified	1
Uterine adenocarcinoma (endometrioid adenocarcinoma Type I)	1
Influenza A virus (IAV) cell entry	1
Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)	1
Activation, HIF1α	1
Activation Sema6A	1
Activation of PPAR	1
Abnormal expression of NO	1
Activation of MMP-2 MMP-9	1
Activation of angiopoietin like protein 4	1
Activation of Angiogenic cytokines	1
Activated ANG/Tie2 pathway	1
Activated BMP/TGF-beta pathway	1
Activated Wnt/Frizzled pathway	1
Activated AKT/ERK/PI3K pathway	1
Inhibition VEGF/VEGFR pathway	1
Vascular barrier disruption	1
Impaired Platelet Aggregation	1
Immune mechanisms antagonized by viral proteins	1
Angiogenesis dysfunction	1
Opening, voltage-gated calcium channels	1
Inhibition, UROD	1
Accumulation, Highly carboxylated porphyrins	1
Induction, CYP1A2/CYP1A5	1
Changes/Inhibition, Cellular Homeostasis and Apoptosis	1
Decreased, PPARalpha transactivation of gene expression	1
Decreased, Mitochondrial Fatty Acid Beta Oxidation	1
Not Increased, Circulating Ketone Bodies	1
Increased, Catabolism of Muscle Protein	1
Decreased, Body Weight	1
Increase, Tissue Degeneration, Necrosis & Atrophy	1
Increase, Respiratory or Squamous Metaplasia	1
Increase, Mutations in Critical Genes	1
Inhibition, SREBP1c	1
Inhibition, NADH-ubiquinone oxidoreductase (complex I)	1
Impaired, Proteostasis	1
KE1 : S-Glutathionylation, eNOS	1
KE3 : Decrease, Tetrahydrobiopterin	1
KE2 : Decrease, GTPCH-1	1
KE7 : Impaired, Vasodilation	1
dimerization, AHR/ARNT	1
reduced dimerization, ARNT/HIF1-alpha	1
Altered, retinal layer structure	1
Decreased, all-trans retinoic acid (atRA) concentration	1
Disrupted meiotic initiation of fetal oogonia of the ovary	1
Reduced size of the ovarian follicle pool	1
Inhibition of Plxna2	1
Overexpression of rasl11b	1
Premature initiation of meiosis in fetal male germ cells	1
abnormal, placental labyrinth vasculature morphology	1
increase, placental insufficiency	1
increase, Preeclampsia	1
increased MyD88 activation	1
Interferon-I antiviral response, antagonized by SARS-CoV-2	1
Repression of Gbx2 expression	1
foxi1 expression, increased	1
six1b expression, increased	1
eya1 expression, inhibited	1
Cystic Fibrosis Transmembrane Regulator Function, Decreased	1
Airway Surface Liquid Height, Decreased	1
Mucociliary Clearance, Decreased	1
Neuronal dysfunction	1
FOXJ1 Protein, Decreased	1
Motile Cilia Number/Length, Decreased	1
Platelet activation, Increased	1
Neutrophil activation, Increased	1
Thromboinflammation, Increased	1
Altered gene expression, NRF2 dependent antioxidant pathway	1
Altered, Neurophysiology	1
Decreased, Nitric Oxide	1
altered, inner ear development	1
Viral infection and host-to-host transmission, proliferated	1
Memory Loss	1
Accumulation, Cytosolic toxic Tau oligomers	1
Hyperphosphorylation of Tau	1
Dysfunctional Autophagy	1
Decrease, GLUT4	1
Inhibition, NMDARs	1
Decrease, Glucose uptake	1
Abnormal, Glucose homeostasis	1
Gestational diabetes mellitus	1
Gut microbiota, alteration	1
Prolongation of Action Potential Duration	1
Prolongation of QT interval	1
Torsades de Pointes	1
Sudden cardiac death	1
Increase, Pollen abnormal	1
transposition of the great arteries	1
Increased, tumor growth	1
Increased, Steroidogenic acute regulatory protein (StAR)	1
Activation of Tumor Protein 53	1
Disruption of sodium channel gating kinetics	1
Up Regulation, FAS	1
Up Regulation, LDLR (low density lipoprotein receptor)	1
Increased, LDL uptake	1
Inhibition, PPAR alpha	1
Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)	1
Inhibition, FoxA2	1
Down Regulation, CPT1A	1
Down Regulation, HMGCS2	1
Decreased, Ketogenesis	1
Activation, NR1H4	1
Activation, SHP	1
Activation, LXR alpha	1
Activation, AKT2	1
Decrease, Ovulation	1
Reduction, Ca and HCO3 transport to shell gland	1
Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts	1
Repressed expression of steroidogenic enzymes	1
Increased apoptosis, decreased fetal/adult Leydig Cells	1
Increase, Ca++ (intracellular)	1
Decreased, Calcium influx	1
Decreased sperm quantity or quality in the adult, Decreased fertility	1
Reduced, Food storage	1
Reduced, Brood care	1
Proliferation, Cell proliferation in the absence of cytotoxicity	1
Accumulation, Damaged mitochondrial DNA	1
Accelerated, Aging	1
Increased, Appetite and hunger	1
Increased, Viral susceptibility	1
impaired, Development	1
Decreased, Hydrogen peroxide production	1
Reduced, Antiseptic incorporated in food	1
Reduced, swimming speed	1
Reduced, feeding 1	1
reduced production, VEGF	1
KE8 : Increase, Vascular Resistance	1
Hypertension	1
Displacement, Serum thyroxine (T4) from transthyretin	1
KE5 : Decrease, AKT/eNOS activity	1
Interference, nuclear localization of NFAT	1
Reduction, NFAT/AP-1 complex formation	1
Decrease, Circulating ecdysis triggering hormone	1
Decrease, Abdominal muscle contraction	1
apoptosis-associated speck-like protein containing a CARD	1
kidney activity	1
granuloma formation	1
medium	1
Suspension	1
apoptosis	1
lysosomal damage	1
caspase-1	1
exfoliation	1
ultraviolet shielding function	1
Zeta-potential	1
surface area	1
cathepsins	1
quantum and tunneling effects	1
Increase, Aneuploid offspring	1
Increase, Necrosis (terminal bronchiolar cells)	1
Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)	1
Increase, Hyperplasia (terminal bronchiolar cells)	1
Increase, Adenomas/carcinomas (bronchioloalveolar)	1
Increase, Hypertrophy and proliferation (follicular cell)	1
Increase, Hyperplasia (follicular cells)	1
Increase, Adenomas/carcinomas (follicular cell)	1
Decreased, Testosterone binding to androgen receptor (hypothalamus)	1
Increase, Leydig cell tumors	1
Decreased, Prolactin	1
Decreased, Progesterone from corpus luteum	1
Increased, Luteinizing hormone (LH)	1
Influenza A Virus production increased	1
Influenza A Virus (IAV) budding	1
Influenza A Virus (IAV) shedding and transmission	1
Decrease, elavl3	1
Decrease, sox10	1
Decrease, mbp	1
Increased, Expression of LXR activated genes	1
Increase, Plasma vitellogenin concentrations	1
Altered expression of cell cycle genes	1
Altered brain morphology	1
Increased, histomorphological alteration of testis	1
inhibition, EKR1/2 signaling pathway	1
autism-like behavior	1
Reduced cortical thickness	1
Epididymal agenesis	1
Impaired, urethral tube closure	1
Decrease Left Ventricular function	1
Antagonism, Glucocorticoid hormone receptor	1
Altered peroxisome proliferator–activated receptor alpha activity	1
Dysregulation of transcriptional expression within PPAR signaling network	1
Disrupted Lipid Storage	1
Activation, PPARα	1
peroxisome proliferator activated receptor promoter demethylation	1
Decreased, PPAR-gamma activation	1
Reduction, Prostaglandin E2 concentration	1
Increase, RBC congestion in liver	1
Production, Reactive oxygen species	1
Increase, Renal pathology due to VTG deposition	1
N/A, Reproductive failure	1
Activation, SCD-1	1
Activation, SREBP-1c	1
Decrease, Steroidogenic acute regulatory protein (STAR)	1
Induction, Sustained Cell Proliferation	1
Induction, Sustained Hepatotoxicity	1
Activation/Proliferation, T-cells	1
Reduction, Angiogenesis	1
Thyroxine (T4) in neuronal tissue, Decreased	1
Activation of specific nuclear receptors, Transcriptional change	1
Decrease, Translocator protein (TSPO)	1
N/A, Unknown	1
Insufficiency, Vascular	1
frustrated phagocytosis	1
autophagy	1
shape	1
Pathogen-associated molecular patterns	1
membrane crossing	1
Apoptosis	1
Surface charge	1
light	1
pro-interleukin (IL)-1β	1
Phagocytosis	1
NF-κB activation	1
NADPH oxidase (NOX1) activation	1
pro-caspase-1	1
cell membrane	1
mitochondrial damage	1
cell adhesion	1
organ (type)	1
Hydrophilicity	1
lactate dehydrogenase	1
liver/spleen activity	1
sedimentation rate	1
activation of caspase-3	1
interaction potential	1
N/A, hypoxia	1
Increased, amputations	1
prolonged, Depolarization of neuronal membrane	1
Overactivation, Neuronotransmitter release	1
Overactivation, muscle contraction	1
Increased, Ataxia, paralysis, or hyperactivity	1
Occurrence, Epileptic seizure	1
Occurrence, A paroxysmal depolarizing shift	1
Increased, locomotion	1
Increased, serotonin (5-HT)	1
Decreased, anxiety	1
Decreased, sheltering	1
Decrease, histaminergic neuron excitation	1
N/A, sedation	1
Reduction, Ionotropic GABA receptor chloride channel conductance	1
Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells	1
Activation, ChREBP	1
Desensitization, Nicotinic acetylcholine receptor	1
Overwhelmed, Mitochondrial DNA repair mechanisms	1
Reduction, Neuronal synaptic inhibition	1
Reduced, Prostaglandin F2alpha synthesis, ovary	1
Reduced, Spawning behavior	1
Reduced, Pheromone release	1
Decline, Population trajectory	1
Decreased, Prostaglandin F2alpha synthesis, ovary	1
Generation, Amplified excitatory postsynaptic potential (EPSP)	1
Reduced, Prostaglandins, ovary	1
Reduced, Prostaglandin E2 concentration, hypothalamus	1
Reduced, Gonadotropin releasing hormone, hypothalamus	1
Reduced, Luteinizing hormone (LH), plasma	1
Reduced, Maturation inducing steroid, plasma	1
Reduced, Maturation inducing steroid receptor signalling, oocyte	1
Increased, cyclic adenosine monophosphate	1
Reduced, Meiotic prophase I/metaphase I transition, oocyte	1
Upregulated, Spindle assembly checkpoint protein Mad2-oocyte	1
Increased, Chromosome misseggregation	1
Altered, Action Potential	1
Increased, cardiac arrthymia	1
Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)	1
Disruption, Microtubule dynamics	1
Disorganization, Meiotic Spindle	1
Increased, Induction of pyruvate dehydrogenase (PDH)	1
Increase, Vitellogenin synthesis in liver	1
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development	1
Loss, Cochlear function	1
N/A, Cyanosis occurs	1
Decrease, Fertility	1
Promotion, Hepatocelluar carcinoma	1

Code examples

curl

curl -s https://raw.githubusercontent.com/h2020-sbd4nano/sbd-data-book/master/sparql/relationshipsByOutcome.rq | sed 's+<lang/>+en+' > relationshipsByOutcome.rq

curl -H "Accept: text/tab-separated-values" -G https://sbd4nanolandscape.rdf.bigcat-bioinformatics.org/sparql --data-urlencode query@relationshipsByOutcome.rq

This SPARQL query is available under CCZero.