GRACIOUS framework blueprint
This document is a HTML translation of the GRACIOUS framework blueprint (Traas, Lion, & Vanhauten, Ralph. (2021). doi:10.5281/zenodo.6140453).
This work is part of SbD4Nano and has received funding from the European Union’s Horizon 2020 research and innovation program under
grant agreement No. 862195.
GroupingPurpose
'precautionary'
'safe-by-design'
'regulatory'
HypothesisOutcome
YesNo
TierLevel
ContextSwitchReason
- Description: Each IATA is evaluated within a fixed context. The context is determined by the target material and the environmental medium in case of environmental IATAs. In case the target material dissolves/transformes and/or moves to another medium due to transport processes a context switch occurs.
A context switch creates a new evaluation context and contains and triggers its own relevant IATAs to be assessed.
This enumeration is used to indicate the cause of that context switch.
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#963f4b5d-dda7-c24b-90b3-53a31ef2b593
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/ContextSwitchReason
coMaterialReadAcross
coMediumReadAcross
coExposureReadAcross
coChemicalReadAcross
coUncoatedReadAcross
coSettleProcess
coTransformationProcess
coDissolutionProcess
coTransportProcess
GroupDescriptor
'NF is respirable, biopersistent, rigid HARN with potential to cause lung hazard'
'NF is respirable, biopersistent, rigid HARN with potential to cause mesothelioma'
'NF aquatic toxicity is driven by the fate and toxicity characteristics of the solutes'
'NF aquatic toxicity is driven by the fate and toxicity characteristics of the NF in aquous environment'
'NF dissolves instantaneous in OGI fluids'
'NF dissolves quick in OGI fluids'
'None biopersistent NF dissolves quick in OGI fluids'
'NF dissolves gradually in OGI fluids'
'Biopersistent and systemic toxic NF and/or constituent ions or molecules'
'Highly biopersistent NF and chronic systemic toxic'
'NF dissolves very slow in OGI fluids'
ContextType
ctHH
ctEnv
ctCS
- Description: The context is determined by a 'contributing scenario' as part of an 'exposure scenario'. Depending on the perspective of the contributing scenario certain 'exposure IATA's are triggered'. The outcome of these exposure IATAs trigger the relevant human health or environmental IATA's (Note only a few exposure IATAs have been implemented)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#00bf0de4-faaa-ce42-875d-0ece9c47cd17
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/ctCS
ctSwitch
ScenarioType
Section
PC_IDENTITY
ID_CAS_REG_NR
ID_EC_REG_NR
ID_CHEMICAL_NAME
ID_IUPAC_NAME
ID_JRC_ID
- Description: The numbering system for the JRC Representative Nanomaterials stored in the JRC Repository has been revised in order to accommodate more nanomaterials and continue to
ensure a high level of traceability. Nanomaterials in the JRC Repository are now identified by the following alphanumeric code (JRC ID): JRCNMXXXYYa, where XXXYY is a number
that is unique to a single nanomaterial. This alphanumeric code (first column in the table) shall be used in publications to refer to the nanomaterials that have been issued by the
JRC Repository. JRCPDZZZKKa is the code used to indicate the pure dispersant (without nanoparticles) in case of nanomaterials provided as dispersion.
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#73b1428b-6a8b-fa4e-a3d8-4b0ae98e268d
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/ID_JRC_ID
ID_SMILES
ID_INCHIKEY
ID_INCHI
ID_EINECS
PC_CLASSIFICATION_LABELING
CLP_HCODE
CLP_HCODE_GENERIC_CONC_LIMIT
CLP_HCODE_SPECIFIC_CONC_LIMIT
CLP_HCODE_M_FACTOR
GHS_CODE
PC_COMPOSITION
- Description: IUCLID : Composition
OHT : Not part of OECD Harmonised Templates
A Substance is defined by its composition. The composition of a Substance can consist of constituents, impurities and additives. This section is a repeatable block section. It enables to enter multiple compositions for a Substance, e.g. to allow different profiles of impurities provided it does not change the identification of the Substance. For detailed instructions on how to define the substance composition in IUCLID, see chapter D.4.1 Substance (create and update substance related information)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#a44057a0-443a-a446-8ab2-02b2788a804c
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/PC_COMPOSITION
EP_CONSTITUENT_ROLE
EP_COMPOSITION_CATEGORY
EP_MASS_CONC
EP_MOLECULAR_FORMULA
EP_PURITY
EP_ELEMENTAL_COMPOSITION_MASS_CONC
EP_ELEMENTAL_COMPOSITION_ATOM_PERC
EP_OXIDATION_DEGREE
PC_APPEARANCE
EP_PHYSICAL_STATE
EP_FORM
EP_ODOUR
- Description: Enumeration with domain MATERIAL_KB::OdourCategory{'ammonia-like', 'biting', 'characteristic of sulfur-containing compounds', 'characteristic of aromatic compounds', 'faint', 'garlic-like', 'odourless', 'pungent', 'slight', 'sweetish','other'}
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#411f0e53-a95d-954f-8c76-4fbf618100d4
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_ODOUR
EP_COLOUR
EP_COLOUR_INTENTSITY
PC_MELTING
PC_BOILING
PC_DENSITY
EP_TRUE_DENSITY
EP_ABSOLUTE_POWDER_DENSITY
EP_APPARENT_PARTICLE_DENSITY
- Description: The mass of a particle divided by its apparent (particle) volume (BSI). Apparent particle volume: The total volume of the particle, excluding open pores, but including closed pores (BSI).
The mass of a particle divided by the total volume of the particle, excluding open pores, but including closed pores.
According to WP3: Apparent particle density EQUALS Skeletal density! (we could decide to delete apparent this one and always use skeletal density)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#01f43651-21fd-9c4d-a4db-40c7066c3c8f
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_APPARENT_PARTICLE_DENSITY
EP_APPARENT_POWDER_DENSITY
EP_BULK_DENSITY
- Description: Bulk density: (also called Bulk powder density):
The apparent powder density under defined conditions (BSI).
The mass of the particles divided by the volume they occupy that includes the space between the particles (ASTM D5004).
The ratio of the mass of a collection of discrete pieces of solid material to the sum of the volumes of: the solids in each piece, the voids within the pieces, and the voids among the pieces of the particular collection (ASTM D3766).
for solids only (IUCLID source)
The density of a solid is derived from the difference in weight between a sample in air and in a liquid of known density (e.g. water). The density thus measured is only representative of the particular sample employed (bulk density). (OECD TG 109, 2012)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#cd154c54-c40c-6e4b-b1f0-751965481a45
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_BULK_DENSITY
EP_EFFECTIVE_DENSITY
- Description: The effective density of nano-agglomerates in liquid suspension refers to the density of the agglomerate unit, which includes both particles and media components, as opposed to the density of the primary particle, which is simply the density of the raw ENM material
(particle effective density) ENM_0000093
Effective particle density: The mass of a particle divided by its volume including open pores and closed pores (BSI).
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#39040fbb-345b-db40-a66f-610173f12c37
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_EFFECTIVE_DENSITY
EP_ENVELOPE_DENSITY
EP_SKELETAL_DENSITY
- Description: The ratio of the mass of discrete pieces of solid material to the sum of the volumes of: the solid material in the pieces and closed (or blind) pores within the pieces (ASTM D3766).
Ratio of sample mass to skeleton volume (ISO 15901-1:2016, skeleton density)
Skeleton volume: volume of the sample including the volume of closed pores (if present) but excluding the volumes of open spores as well as that of void spaces between particles within the bulk sample (ISO 15901-1:2016, source: ISO 12514)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#a2df7aed-d63d-d84b-b851-8749519e6aed
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_SKELETAL_DENSITY
EP_TAP_DENSITY
- Description: The apparent powder density obtained under stated conditions of tapping (BSI).
Nanoreg D2_03 Tap density describes the mass per volume after powder compaction in a cylinder (50 times repeated 25 mm drop of a cylinder onto a rubber pad) or by the use of a Dry Substance Jolting Volumeter (ISO 787).
A known weight of a solid material is placed in a glass graduated (i.e. measuring) cylinder and its volume measured to determine the ‘pour density.’ The cylinder is then raised and allowed to fall vertically through a distance of 25 mm on a rubber pad 50 times (or this may be performed using a Dry Substance Jolting Volumeter as described in ISO 787/11). The volume is measured again to determine the ‘tap density.’ (OECD TG 109, 2012)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#489664de-3296-6e41-86bd-7a81a753daa8
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_TAP_DENSITY
EP_THEORETICAL_DENSITY
- Description: The ratio of the mass of a collection of discrete pieces of solid material to the sum of the volumes of said pieces, the solid material having an ideal regular arrangement at the atomic level (ASTM).
Theoretical density is true density of a material corresponding to the limit attainable through full density products without pores. (https://www.sciencedirect.com/topics/engineering/theoretical-density)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#e462ef6a-1a5d-9044-9a41-5f8bf05ae0ed
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_THEORETICAL_DENSITY
EP_RELATIVE_DENSITY
- Description: Relative density is the ratio of the density (mass of a unit volume) of a substance to the density of a given reference material.
(dimensionless unit)
The relative density (D20/4, density at 20 degrees Centigrade relative to water at 4 degrees Centigrade) may be used to compare different chemicals. (OECD TG 109, 2012)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#62495e36-c305-ab40-b2b4-0acf7c4df699
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_RELATIVE_DENSITY
PC_GRANULOMETRY
- Description: IUCLID 4.5 Particle size distribution (Granulometry)
OHT 5: Particle size distribution (Granulometry)/Fibre length and diameter distribution
A typical order of length scale is: largest dimension > hydrodynamic diameter > volume (or mass) equivalent diameter > Stokes diameter > VSSA equivalent diameter > smallest dimension (Appendix 4).
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#6f86a312-e6e4-8c47-86e5-4ef3ff14106c
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/PC_GRANULOMETRY
EP_NOMINAL_DIAMETER
EP_NOMINAL_LENGTH
EP_PRIMARY_PARTICLE_DIAMETER
- Description: primary particle: original source particle (3.1) of agglomerates (3.4) or aggregates (3.5) or mixtures of the two [SOURCE: ISO 26824:2013, 1.4] (ISO/TS 80004-2:2015)
Primary particles are the original seeds from which particles grow and are therefore an unrelated concept to constituent particles, aggregates and agglomerates.
Therefore, the term ‘primary particle’ is irrelevant for the EC NM definition. (JRC Report 2019, An overview of concepts and terms used in the European Commission’s definition of nanomaterial)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#3dfbad0a-a56f-ad48-9527-7e07a6e86cdf
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_PRIMARY_PARTICLE_DIAMETER
EP_PRIMARY_PARTICLE_LENGTH
EP_CONSTITUENT_PARTICLE_SIZE
EP_FERET_DIAMETER_D1
- Description: Feret’s diameter D1 (minimum distance edge to edge, the minor axis). Minimum diameter D1 corresponds to the ”breadth” of the particle. [ISO 9276-6:2008 8.1.2]
In case of agglomerates/aggregates the minimum Feret diameter (EP_FERET_DIAMETER_D1) refers to the entire agglomerate/aggregate, whereas the maximum inscribed circle (EP_LARGEST_INTERNAL_CIRCLE) does
not refer to the entire aggregate, but to the constituent particles of the agglomerate/aggregate ( from the NanoDefine project [21] ).
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#0f031e75-6b55-8748-bf58-56dc50c2974d
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_FERET_DIAMETER_D1
EP_FERET_DIAMETER_D3
EP_LARGEST_INTERNAL_CIRCLE
- Description: Largest internal circle or maximum inscribed circle diameter: it is the diameter of the largest circle that fits inside the virtual envelope of the boundaries of the particle on a 2D image.
In case of agglomerates/aggregates the minimum Feret diameter (EP_FERET_DIAMETER_D1) refers to the entire agglomerate/aggregate, whereas the maximum inscribed circle does
not refer to the entire aggregate, but to the constituent particles of the agglomerate/aggregate ( from the NanoDefine project [21] ).
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#358e3d5a-dc6b-0a4e-bec9-3c7ce42e5ad4
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_LARGEST_INTERNAL_CIRCLE
EP_LEGENDRE_ELLIPSE_D1
EP_LEGENDRE_ELLIPSE_D3
EP_GEODESIC_LENGTH_D3
EP_GEODESIC_THICKNESS
EP_EQUIVALENT_CIRCLE_DIAMETER
EP_SURFACE_EQ_SPHERE_DIAMETER
EP_VOLUME_EQ_SPHERE_DIAMETER
EP_VOLUME_EQ_DISC_DIAMETER
EP_VOLUME_EQ_DISC_THICKNESS
EP_VOLUME_EQ_CYLINDER_DIAMETER
EP_VOLUME_EQ_CYLINDER_LENGTH
EP_HYDRODYNAMIC_EQ_SPHERE_DIAMETER
- Description: Hydrodynamic equivalent diameter D_hydro (= diameter of a sphere with the same translational diffusion coefficient as the particle in the same fluid under the same conditions)
equivalent spherical diameter of a particle in a liquid having the same diffusion coefficient as the real particle in that liquid [SOURCE: ISO/TS 80004‑6:2013, 3.2.6]
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#084598dc-14ec-894d-bbdb-4ec6ee986c4a
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_HYDRODYNAMIC_EQ_SPHERE_DIAMETER
EP_Z_AVERAGE_DIAMETER
- Description: The Z-Average size or Z-Average mean used in dynamic light scattering is a parameter also known as the cumulants mean. It is the primary and most stable parameter produced by the technique. The Z-Average mean is the best value to report when used in a quality control setting as it is defined in ISO 13321 and more recently ISO 22412 which defines this mean as the harmonic intensity averaged particle diameter.
Z-average size is the intensity weighted harmonic mean size
The intensity-weighted mean diameter derived from the cumulants analysis
Intensity weighted hydrodynamic diameter. Z-AVE HYDRODYNAMIC DIAMETER (DLS RESULT)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#7782e301-b48b-fe44-a227-bb131a61441d
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_Z_AVERAGE_DIAMETER
EP_INTENSITY_WEIGHTED_SIZE
EP_STOKES_EQ_SPHERE_DIAMETER
EP_AERODYNAMIC_EQ_SPHERE_DIAMETER
- Description: The diameter in [nm] of an equivalent spherical particle with unit density and the same settling velocity in air as the particle under consideration.
The aerodynamic diameter of an irregular particle is defined as the diameter of the spherical particle with a density of 1000 kg/m3 and the same settling velocity as the irregular particle. (Wikipedia)
The diameter of a sphere with unit density that has aerodynamic behavior identical to that of the particle in question; an expression of aerodynamic behavior of an irregularly shaped particle in terms of the diameter of an idealized particle. Particles having the same aerodynamic diameter may have different dimensions and shapes.
[https://www.opentoxipedia.org/index.php/Aerodynamic_diameter]
[constraint, only relevant if medium.physical_state = gas]
The median aerodynamic diameter => MAD
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#4f0951c5-3fa1-6744-b57c-df5ed9a213bd
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_AERODYNAMIC_EQ_SPHERE_DIAMETER
EP_MASS_MEDIAN_AERODYNAMIC_DIAMETER
EP_SIEVE_EQ_SPHERE_DIAMETER
EP_ELECTRICAL_MOBILITY_EQ_SPHERE_DIAMETER
EP_DISPERSITY
- Description: This index is a number calculated from a simple 2 parameter fi t to the correlation data (the cumulants analysis). The dispersity (PDI) is dimensionless and scaled such that values smaller than 0.05 are rarely seen other than with highly monodisperse standards. Values greater than 0.7 indicate that the sample has a very broad size distribution and is probably not suitable for the dynamic light scattering (DLS) technique. The various size distribution algorithms work with data that falls between these two extremes. The calculations for these parameters are defined in the ISO standard document 13321:1996 E and ISO 22412:2008.
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#7208ffbc-d096-e94b-9b46-684ca340439c
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_DISPERSITY
EP_DISPERSITY_2
EP_MODE_COUNT
EP_FULL_WIDTH_AT_HALF_MAXIMUM
EP_RADIUS_OF_GYRATION
EP_GEOMETRIC_MEAN_DIAMETER
EP_DERIVED_COUNT_RATE
EP_RELATIVE_INTENSITY
EP_DIMENSION
EP_OBSERVATION_SCALE
EP_DmPx_D1
EP_DmPx_D2
EP_DmPx_D3
EP_DnPx_D1
EP_DnPx_D2
EP_DnPx_D3
EP_DvPx_D1
EP_DvPx_D2
EP_DvPx_D3
EP_DsPx_D1
EP_DsPx_D2
EP_DsPx_D3
EP_DiPx_D1
EP_DiPx_D2
EP_DiPx_D3
PC_VAPOUR
PC_PARTITION
EP_LOG_POW
- Description: The partition coefficient between water and 1-octanol (POW) is defined as the ratio of the equilibrium concentrations of the test substance in 1-octanol saturated with water (CO) and water saturated with 1-octanol (CW).
POW = CO / CW
As a ratio of concentrations it is dimensionless. Most frequently it is given as the logarithm to the base 10 (log POW). POW is temperature dependent and reported data should include the temperature of the measurement. (OECD TG 123, 2006)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#04123392-3f14-db41-bf16-692d4bcf0981
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_LOG_POW
EP_LOG_K_VALUE
EP_CONC_IN_WATER
EP_CONC_IN_OCTANOL
PC_WATER_SOL
EP_WATER_SOL
EP_DISSOLUTION_RATE
EP_DISSOLUTION_HALF_TIME
EP_DISSOLUTION_MASS_LOSS
EP_INTRACELLULAR_DISSOLUTION_RATE
EP_INTRACELLULAR_DISSOLUTION_HALF_TIME
EP_INTRACELLULAR_DISSOLUTION_MASS_LOSS
EP_TRANSFORMATION_D1
EP_TRANSFORMATION_D3
EP_TRANSFORMATION_MORPHOLOGY
EP_SOLUBILITY
- Description: The solubility of a substance in a given media is the saturation mass concentration of the substance in that given solvant at a given temperature. The solubility is expressed in mass of solute per volume of solution. The SI unit is kg/m3 but g/l is commonly used.(OECD Guidline 105)
The quantity of solute that dissolves in a given quantity of solvent to form a saturated solution (OECD Guidance Documents 317 & 318)
However, unit ppm is used in IATA.
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#2b75095a-5b5e-c94c-8bfb-1531ac535541
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_SOLUBILITY
EP_PERCENTAGE_DISSOLVED
PC_SOL_ORGANIC
EP_SOL_ORGANIC
- Description: The mass fraction of a substance which forms a homogeneous phase with a liquid fat(oil) without giving rise to chemical reactions is defined as fat solubility. The maximum of such mass fraction is called the saturation mass fraction, and this is a function of temperature. The composition of fats will differ from organism to organism and even within a single organism. Since it is desirable to be able to compare results from different laboratories, it is necessary to employ standard fat. This standard fat should be similar in composition and behaviour to materials occurring naturally, and a commercial triglyceride mixture described in the Annex satisfies this requirement, although any other mixtures of triglycerides that give demonstrably comparable results can be used. The saturation mass fraction of a substance should be given in g/kg of standard fat and referenced to 37°C ± 0.5°C. (OECD TG 116, 1981)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#1bcfe5fc-fb7c-9045-8802-b9d49128b223
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_SOL_ORGANIC
PC_SURFACE_TENSION
EP_WATER_CONTACT_ANGLE
- Description: When a liquid does not spread on a substrate (usually a solid), a contact angle (θ) is formed which is defined as the angle between two of the interfaces at the three-phase line of contact. It must always be stated which interfaces are used to define θ. It is often necessary to distinguish between the 'advancing contact angle' (θa), the 'receding contact angle' (θr) and the 'equilibrium contact angle' (θe). (IUPAC Gold Book, https://goldbook.iupac.org/terms/view/C01290)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#9c52aafa-5058-734e-89e0-3a72d7638872
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_WATER_CONTACT_ANGLE
PC_STABILITY_THERMAL_SUNLIGHT_METALS
EP_MASS_LOSS
- Description: Thermogravimetric analysis (TGA) is conducted on an instrument referred to as a thermogravimetric analyzer. A thermogravimetric analyzer continuously measures mass while the temperature of a sample is changed over time. Mass, temperature, and time in thermogravimetric analysis are considered base measurements while many additional measures may be derived from these three base measurements.
TGA provide thus the weight loss [%] or mass loss [g] (of the organic matter) as a function of temperature.
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#354ffb6f-dfbd-2644-941c-41fb3faf881f
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_MASS_LOSS
EP_MASS_LOSS_WATER
PC_NON_SATURATED_PH
EP_PH
- Description: pH is defined as the decimal logarithm of the reciprocal of the hydrogen ion activity in a solution.( Covington, A. K.; Bates, R. G.; Durst, R. A. (1985). "Definitions of pH scales, standard reference values, measurement of pH, and related terminology" (PDF). Pure Appl. Chem. 57 (3): 531–542. doi:10.1351/pac198557030531.) OECD 122 (Test Guideline) Electrometric determination of pH measures the negative log10 aqueous hydronium ion concentration of ideal solutions. Dimensionless quantity.
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#6f6928ed-c594-a144-b248-f462ef36d5d8
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_PH
PC_DISSOCIATION
- Description: IUCLID 4.21: Dissociation constant
OHT 21: Stability: Dissociation constant
OECD GD 112: Dissociation is the reversible splitting into two or more chemical species which may be ionic. The process is indicated generally by: RX ⇌ R+ + X- and the concentration equilibrium constant governing the reaction is K= [R+][X-]/[RX]
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#35312a60-449f-a249-bc7c-151a6ceafbc1
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/PC_DISSOCIATION
PC_VISCOSITY
EP_VISCOSITY
- Description: OECD GD 114: Viscosity is the property of a fluid substance of absorbing a stress during deformation which depends on the rate of the deformation. Similarly, the stress can be regarded as the cause which brings about a deformation rate. The shear stress τ and the shear rate D are related by the equation: τ= η D. η is defined as the dynamic viscosity. The SI unit of dynamic viscosity is the Pascal second, [Pa s]. The SI unit of kinematic viscosity (dynamic viscosity divided by the density of the fluid) is the square metre per second, [m2/s].
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#31773afb-b057-5d4b-b6e6-6c62c3c9cb9b
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_VISCOSITY
PC_AGGLOMERATION_AGGREGATION
- Description: IUCLID 4.24: Agglomeration/aggregation
OHT 101: Nanomaterial agglomeration/aggregation
OECD TG318: Process of contact and adhesion whereby dispersed particles are held together by weak physical interactions ultimately leading to enhanced sedimentation by the formation of precipitates of larger than colloidal size (agglomerates) (slightly modified according to 7). In contrast to aggregation where particles held by strong bonds like sinter bridges, agglomeration is a reversible process.
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#f63dea04-80e4-3e4b-b1bc-bdd501b41734
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/PC_AGGLOMERATION_AGGREGATION
EP_AA_INDEX
EP_AA_RATIO
EP_FRACTAL_DIMENSION
- Description: Fractal Dimension (DF) is the power that an equivalent radius of a NP agglomerate scales to in order to scale to its mass. A DF of 3 hence corresponds to a solid sphere (no porosity) and a value of 1 describes a rod.
NP agglomerates can be divided into diffusion limited agglomerates (DLCA) with DF values of approximately 1.8, and reaction limited cluster agglomerates (RCLA) with a DF value between 2.1 and 2.5. (SAX, VCM)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#8085874e-b8d4-b845-8847-26f73f92917b
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_FRACTAL_DIMENSION
PC_CRYSTALLINE_PHASE
EP_CRYSTALLINITY
EP_CRYSTAL_SYSTEM
- Description: A material in which the atoms are arranged in a translationally periodic array in the three dimensions or which are arranged in rotationally periodic arrays in three dimensions (Cullity, 1978, Element of X-Ray Diffraction, Second Edition, Addison-Wesley Publishing Co., Reading, MA, 1978). In total there are seven crystal systems: triclinic, monoclinic, orthorhombic, tetragonal, trigonal, hexagonal, and cubic.
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#2855812d-5787-ff40-9a93-8b68844ea754
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_CRYSTAL_SYSTEM
EP_SPACE_GROUP
- Description: A space group is the symmetry group of a configuration in space, usually in three dimensions. In crystallography, space groups are also called the crystallographic or Fedorov groups, and represent a description of the symmetry of the crystal. (Hiller, Howard (1986). "Crystallography and cohomology of groups". Amer. Math. Monthly. 93 (10): 765–779. doi:10.2307/2322930. JSTOR 2322930). Crystals can be classified according to 230 space groups and a space group can be referred to by a number or the space group symbol.
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#28a9240e-5eb7-2a40-9c3a-01d879416afb
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_SPACE_GROUP
EP_MINERAL_NAME
PC_CRYSTALLITE_AND_GRAIN_SIZE
EP_CRYSTALLITE_SIZE
EP_GRAIN_SIZE
PC_ASPECT_RATIO_SHAPE
EP_ASPECT_RATIO_D3_D1
EP_ELLIPSE_RATIO_D3_D1
EP_ASPECT_RATIO_D1_D3
EP_ELLIPSE_RATIO_D1_D3
EP_COMPACTNESS
EP_ROUNDNESS
EP_CIRCULARITY
- Description: Circularity, is defined as the degree to which the particle is similar to a circle, taking into consideration the smoothness of the perimeter. This means circularity is a measurement of both the particle form and roughness. Thus, the further away from a perfectly round, smooth circle a particle becomes, the lower the circularity value. Circularity is a dimensionless value.
[ISO9276-6 8.2]
Degree to which the particle (or its projection area) is similar to a circle, considering the smoothness of the perimeter:
SQRT( 4π x [Area] / [Perimeter]^2 )
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#6383e4cc-4d9a-114b-8766-b4dae68a1a03
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_CIRCULARITY
EP_CIRCULARITY_FORM_FACTOR
EP_SOLIDITY
- Description: Solidity, S, is the measurement of the overall concavity of a particle. It is defined as the image area, A, divided by the convex hull area, Ac, as given in Equation 9. Thus, as the particle becomes more solid, the image area and convex hull area approach each other, resulting in a solidity value of one. However, as the particle form digresses from a closed circle, the convex hull area increases and the calculated solidity decreases. Solidity is a dimensionless value.
[ISO9276-6 8.2]
Measure of the overall concavity of a particle:
Solidity = [Area]/ [Ac] where Ac is the area of the convex hull (envelope) bounding the particle
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#7230e022-2fe9-1a4a-9ce5-13b5c03ffbe3
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_SOLIDITY
EP_CONVEXITY
- Description: Convexity, Cx, is a measurement of the particle edge roughness and is defined as the convex hull perimeter, Pc, divided by the actual perimeter, P, as given in Equation 8. Thus, as the surface of the particle becomes rough, the actual perimeter increases, thus lowering the convexity measurement. Convexity is a dimensionless value.
[ISO9276-6 8.2]
Convexity Pc / P = where Pc is the length of the perimeter of the convex hull (envelope) bounding the particle []
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#3f93825d-8e68-654d-a7ca-960cd6a119f4
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_CONVEXITY
EP_DYNAMIC_SHAPE_FACTOR
EP_SHAPE_CATEGORY
EP_SHAPE_SUBCATEGORY
EP_ASSEMBLY_STRUCTURE_CP
EP_ASSEMBLY_STRUCTURE_AGG
EP_NUMBER_OF_LAYERS
EP_NUMBER_OF_WALLS
PC_SPECIFIC_SURFACE_AREA
EP_SURFACE_AREA
- Description: extent of available surface area as determined by a given method under stated conditions
Note 1 to entry: For the purposes of this International Standard, the area includes the external surface of a solid plus the internal surface of its accessible macro-, meso- and micropores.
[SOURCE: ISO 15901-1:2006[1], 3.25]
Is this the same as absolute surface area or total surface??
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#e0479312-9b4a-2841-a5b4-ba55c2dc9699
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_SURFACE_AREA
EP_MASS_SPECIFIC_SURFACE_AREA
EP_SBET
EP_VOLUME_SPECIFIC_SURFACE_AREA
EP_MASS_EXTERNAL_SURFACE
EP_VOLUME_EXTERNAL_SURFACE
EP_MASS_MICROPOROSITY_SURFACE
EP_TITRATOR_VOLUME
EP_SURFACE_AREA_TO_VOLUME_RATIO
PC_ZETA_POTENTIAL
EP_ZETA_POTENTIAL
- Description: Zeta Potential–electrokinetic potential: the electric potential at the shear plane of the diffuse double layer. The zeta potential is derived from electro-kinetic phenomena, the movement of the particles in an electric field. The conversion of electrophoretic mobility measurements into zeta potential requires several assumptions about the properties of the double layer.As long as the assumptions are always identical, identical conversions and hence zeta potentials are retrieved. Reporting zeta potentials would require the reporting of the assumptions made to make them comparable. [OECD TG 318]
Unit: [mV]
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#a6db92bf-fc90-9f4c-9f98-667182b4db79
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_ZETA_POTENTIAL
EP_ISOELECTRIC_POINT
PC_SURFACE_CHEMISTRY
EP_ATOMIC_COMPOSITION
- Description: Add to composition..
Atomic composition of the surface chemistry may refer to hyphenating the TGA (in EP_MASS_LOSS) to evolved gas analysis such as mass spectrometry (TGA-MS). This allows quantitative analysis of the polymer compounds in the material. Another common tool is to hyphenate with FTIR for infra red spectrometry (TGA-FTIR). I am not sure if these come under the same endpoint e.g. EP_EVOLVED_GAS_ANALYSIS or if TGA-MS should be under EP_ATOMIC_COMPOSITION whilst TGA-FTIR should be under EP_COMPOUND_CLASS (or something similar). I ask this because they deliver importantly different results, but in effect give you a quantitative measure of the chemical composition of the polymer. See definitions below for more detail. "TGA-FTIR can be compared to spectral reference databases for identifying the chemical class or family of the unknowns. In many cases, the chemistries can be narrowed down to specific compounds" "TGA-MS provides a sensitive method for analyzing TGA gaseous products in detail... Tentative identification of the original gas products can be performed in two steps: (1) assigning the structure of the fragment ions using the mass data, and, (2) correlating the assigned fragment structures with known fragmentation patterns of specific molecules."definitions from https://www.eag.com/techniques/phys-chem/tga-ega/ as an example.
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#4cbdba71-5283-994e-abf2-4021037bcf4d
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_ATOMIC_COMPOSITION
EP_MASS_LOSS
- Description: Thermogravimetric analysis (TGA) is conducted on an instrument referred to as a thermogravimetric analyzer. A thermogravimetric analyzer continuously measures mass while the temperature of a sample is changed over time. Mass, temperature, and time in thermogravimetric analysis are considered base measurements while many additional measures may be derived from these three base measurements.
This is considered part of PC_SURFACE_CHEMISTRY as this technique can be used to measure the % mass loss on heating. This can be used to infer the % mass of coatings in a nanomaterial sample. Example of micro-TGA https://doi.org/10.1021/ac402888v
Standards for TGA are ASTM E1131, ISO 11358
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#4109799b-4605-b541-9163-7afb9e823ae9
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_MASS_LOSS
EP_NOMINAL_INORGANIC_COMPOSITION
EP_NOMINAL_ORGANIC_COMPOSITION
PC_DUSTINESS
EP_RESPIRABLE_DUST_INDEX_MASS
EP_RESPIRABLE_DUST_INDEX_NUMB
EP_THORACIC_DUST_INDEX_MASS
EP_THORACIC_DUST_INDEX_NUMB
EP_INHALABLE_DUST_INDEX_MASS
EP_INHALABLE_DUST_INDEX_NUMB
PC_AEROSOL_CHARACTERISATION
EP_AEROSOLISED_PARTICLE_CONC
PC_POROSITY
EP_VOID_SPACE_FRACTION
EP_SPECIFIC_PORE_VOLUME
EP_MODAL_PORE_DIAMETER
EP_PORE_SIZE
EP_PORE_RADIUS
PC_POUR_DENSITY
- Description: IUCLID 4.33: Pour density
OHT 110: Nanomaterial pour density
IUCLID 5.0 manual
4.34.1.20. Pour density or void fraction is a measure of the void (i.e. 'empty') spaces in a material,and is a fraction of the volume of voids over the total volume.
I DON'T THINK THIS IS THE CORRECT DEFINITION... it is the same as POROSITY definition in IUCLID 5.0.. I guess they mixed up pore and pour!!!
Nanoreg D2_03: Pour density, also called bulk or apparent density, is given by the mass per volume that a given powder occupies as poured directly into a container without any further compaction.
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#9a5ebc3b-9753-d344-b3c7-3029d6d0a223
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/PC_POUR_DENSITY
EP_POUR_DENSITY
- Description: Pour density, also called bulk or apparent density, is given by the mass per volume that a given powder occupies as poured directly into a container without any further compaction.
Might be equal to PC_DENSITY::EP_APPARENT_POWDER_DENSITY, PC_DENSITY::BULK_DENSITY
A known weight of a solid material is placed in a glass graduated (i.e. measuring) cylinder and its volume measured to determine the ‘pour density.’ (OECD TG 109, 2012).
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#1bc616c6-1b36-6341-b8c2-8590fa46b059
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_POUR_DENSITY
PC_PHOTOCATALYTIC_ACTIVITY
PC_RADICAL_FORMATION_POTENTIAL
EP_OH_RADICAL_FORMATION_POTENTIAL
EP_OXIDATIVE_DAMAGE_PER_DOSE
EP_BIOLOGICAL_OXIDATIVE_DAMAGE_MASS_DOSE
EP_BIOLOGICAL_OXIDATIVE_DAMAGE_SURF_DOSE
EP_OXIDATIVE_DAMAGE_AUC_MASS
EP_OXIDATIVE_DAMAGE_AUC_SURFACE
EP_SPIN_COUNT_PER_SURFACE_CONC
EP_SURFACE_REACTIVITY_CPH_DH20_MASS
EP_SURFACE_REACTIVITY_CPH_DH20_SURF
EP_SURFACE_REACTIVITY_DMPO_DH20_MASS
EP_SURFACE_REACTIVITY_DMPO_DH20_SURF
EP_FLUORESCENCE_480_530_AU
EP_DCFH_ROS_GENERATION_AU
EP_DCFH_OXIDATION_MASS
EP_DCFH_OXIDATIVE_STRESS_PERC_OF_CONTROL
EP_DCFH_SCORE_MASS
EP_DCFH_INTRINSIC_ROS_CHANGE_IN_RFU
EP_EPR_SCORE_SURF
EP_EPR_SCORE_MASS
EP_EPR_SIGNAL_INTENSITY
EP_EPR_SIGNAL_INTENSITY_PERC_OF_CONTROL
EP_FRAS_SCORE_MASS
EP_FRAS_SCORE_SURF
PC_CATALYTIC_ACTIVITY
- Description: IUCLID 4.36: Catalytic activity
OHT 113: Nanomaterial catalytic activity
In the REACH context this seems to be descriptive rather than any specific measurable quantity linked to a specific assay, i.e. any available studies relevant to the catalytic properties of the nanomaterial are summarised.
Increase in the rate of reaction of a specified chemical reaction that an enzyme produces in a specific assay system. (IUPAC Gold Book https://goldbook.iupac.org/terms/view/C00881)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#4bb9637e-1168-5a4c-a7ec-ac6ea80429ee
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/PC_CATALYTIC_ACTIVITY
PC_RIGIDITY
- Description: Newly introduced Gracious (ThinkWorks)
Rigidity, in the context of this Guidance, is the ability of an elongated particle or platelet to retain its shape, without damage, when subject to mechanical (bending) forces. (ECHA-19-H-14-EN , Appendix for nanoforms applicable to the Guidance on Registration and Substance Identification )
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#9f0c1c33-1b90-a149-9f1f-bf70867b6afb
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/PC_RIGIDITY
EP_STATIC_BENDING_PERSISTENCE_LENGTH
EP_BENDING_RATIO
EP_CONTOUR_LENGTH
EP_BIOLOGICAL_STIFFNESS
EP_YOUNGS_MODULUS
EP_SHEAR_MODULUS
- Description: In materials science, shear modulus or modulus of rigidity, denoted by G, or sometimes S or μ, is a measure of the elastic shear stiffness of a material and is defined as the ratio of shear stress to the shear strain.
The shear modulus G describes the material's response to shear stress (like cutting it with dull scissors).
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#bfd46ee3-473a-bc4f-8298-a17dd319f09b
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_SHEAR_MODULUS
PC_HYDROPHOBICITY
EP_WATER_CONTACT_ANGLE
- Description: Perhaps this is already covered in the PC_SURFACE_TENSION category
Method to measure of wettability (and hydrophobicity thus) of solid surface by water via the Young equation. Unit [°].
Water contact angle (WCA) is the angle formed tangential to the water droplet at the air–liquid–solid interface. A WCA less than 90 degree is an indication of a wettable surface; a WCA greater than 90 degree indicates poor wettability. (doi.org/10.1016/B978-0-12-802926-8.00002-1)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#d64ce966-3063-0b4b-9206-621228361d90
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_WATER_CONTACT_ANGLE
PC_BIOMOL_INTERACTION
EP_BINDING_ENERGY
EP_BINDING_ENTHALPY
EP_BINDING_ENTROPY
EN_PHOTOTRANS_AIR
EN_HYDROLYSIS
EN_PHOTOTRANS_WATER
EN_PHOTOTRANS_SOIL
EN_BIODEG_WATER_SCREEN
EN_BIODEG_WATER_SIM
EN_BIODEG_SOIL
EN_DEGR_MODE_IN_USE
EN_BIOACCU_AQUATIC_SED
EN_BIOACCU_TERRESTRIAL
EN_ADSORPTION
EN_HENRY_LAW
EN_DISPERSION_STABILITY_NANOMATERIAL
EP_DISPERSION_STABILITY
- Description: Dispersion stability refers to the ability of a dispersion to resist change in its properties over time.
Ability to resist change or variation in the initial properties (state) of a dispersion over time, in other words, the quality of a dispersion in being free from alterations over a given time scale. [ISO 13097:2013]
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#31642965-19c7-6d4b-9bdd-e6e4cfbf4bf9
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_DISPERSION_STABILITY
EP_BATCH_RETENTION_COEFFICIENT
EN_BIODURABILITY
EC_FISH_TOX_SHORT
EP_MORTALITY
EP_DEVELOPMENT
EP_COAGULATION_OF_FERTILISED_EGGS
EP_LACK_OF_SOMITE_FORMATION
EP_LACK_OF_DETACHMENT_OF_TAIL_BUD_FROM_YOLK_SAC
EP_LACK_OF_HEARTBEAT
EP_LYSOSOMAL_INTEGRITY
EP_METABOLIC_ACTIVITY
EP_PLASMA_MEMBRANE_INTEGRITY
EC_FISH_TOX_CHRONIC
EP_MORTALITY
EP_DEVELOPMENT
EP_GROWTH
EP_HATCHING
EP_SURVIVAL
EP_WEIGHT
EP_LENGTH
EP_ABNORMAL_APPEARANCE_AND_BEHAVIOR
EC_AQUATIC_INVERT_TOX_SHORT
EP_IMMOBILIZATION
EP_GROWTH
EP_YIELD
EP_BIOMASS
EP_MORTALITY
EC_AQUATIC_INVERT_TOX_CHRONIC
EP_REPRODUCTION
EP_HATCHING
EP_GROWTH
EP_IMMOBILIZATION
EC_ALGAE_TOX
EP_GROWTH
EP_BIOMASS
EP_YIELD
EC_AQ_PLANTS_NONE_ALGAE
EC_BAC_TOX
EP_GROWTH_INHIBITION
- Description: -The cell multiplication inhibition for a tested concentration expressed as a percentage. Example of calculation given in ISO 10712 https://www.iso.org/standard/18800.html
-ECx: Effective concentration for growth inhibition - Concentration of the test sample giving a calculated or interpolated inhibition of cell multiplication compared to that of the control treatment. Example taken from ISO 10712 https://www.iso.org/standard/18800.html
-NOEC (no observed effect concentration) is the test substance concentration at which no effect is observed. For example, the concentration corresponding to the NOEC, has no statistically significant effect (p < 0.05) within a given exposure period when compared with the control.
-LOEC (lowest observed effect concentration) is the test substance concentration for which the effect is significantly different from control.
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#d5293a96-8cad-b64c-ac73-af8867f5257b
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_GROWTH_INHIBITION
EP_NITRIFICATION_INHIBITION
EP_RESPIRATION_INHIBITION
- Description: NOEC (no observed effect concentration) is the test substance concentration at which no effect is observed. In this test, the concentration corresponding to the NOEC, has no statistically significant effect (p < 0.05) within a given exposure period when compared with the control. Definition from OECD TG 209
https://www.oecd-ilibrary.org/environment/test-no-209-activated-sludge-respiration-inhibition-test_9789264070080-en
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#df0a9427-b890-134e-915e-2d42092623a2
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_RESPIRATION_INHIBITION
EP_OXYGEN_CONSUMPTION
EC_SEDIMENT_TOX
EP_EMERGENCE
EP_GROWTH
EP_SURVIVAL
EP_LUMINESCENCE
EP_REPRODUCTION
EP_DEVELOPMENT
EP_DEVELOPMENT_RATE
EP_SEX_RATIO
EC_SOIL_TOX
EP_SURVIVAL
EP_REPRODUCTION
EC_TERR_ARTHROP_TOX
EP_DEVELOPMENT
EP_EMERGENCE
EP_FEMALE_SURVIVOR
EP_HATCHING
EC_TERR_PLANT_TOX
EP_DRY_SHOOT_WEIGHT
EP_EMERGENCE
EC_SOIL_MICRO_TOX
EC_BIRDS_TOX
EP_CRACKED_EGGS
EP_EGG_PRODUCTION
EP_EGG_SHELL_THICKNESS
EP_HATCHABILITY_AND_EFFECTS_ON_YOUNG_BIRDS
HH_BASIC_TOX
EP_IN_VIVO_ACCUMULATION
- Description: Accumalated dose mg of released ion/kg or particles identification / quantification (see. OECD TG 417)
Accumulation (Bioaccumulation): Increase of the amount of a substance over time within tissues (usually
fatty tissues, following repeated exposure); if the input of a substance into the body is greater than the rate
at which it is eliminated, the organism accumulates the substance and toxic concentrations of a substance
might be achieved;
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#1849627e-0f5e-3a4d-82ab-9e964d4f730c
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/EP_IN_VIVO_ACCUMULATION
HH_DERMAL_ABSORP
HH_ACUTE_TOX_ORAL
HH_ACUTE_TOX_INHAL
HH_ACUTE_TOX_DERMAL
HH_SKIN_IRRITATION
HH_EYE_IRRITATION
HH_SKIN_SENSITISATION
HH_RESP_SENSITISATION
HH_REPEATED_ORAL
EP_CELL_NUMBER_IN_BALF
EP_ALVEOLAR_MACROPHAGES_NUMBER_IN_BALF
EP_ALVEOLAR_NEUTROPHILS_NUMBER_IN_BALF
EP_ALVEOLAR_LYMPHOCYTES_NUMBER_IN_BALF
EP_ALVEOLAR_EOSINOPHILS_NUMBER_IN_BALF
EP_ALVEOLAR_MACROPHAGE_PERC_IN_BALF
EP_ALVEOLAR_NEUTROPHILS_PERC_IN_BALF
EP_ALVEOLAR_LYMPHOCYTES_PERC_IN_BALF
EP_ALVEOLAR_EOSINOPHILS_PERC_IN_BALF
HH_REPEATED_INHAL
EP_ALVEOLAR_MACROPHAGE_PERC_IN_BALF
EP_ALVEOLAR_NEUTROPHILS_PERC_IN_BALF
EP_ALVEOLAR_MACROPHAGES_NUMBER_IN_BALF
EP_ALVEOLAR_NEUTROPHILS_NUMBER_IN_BALF
HH_REPEATED_DERMAL
HH_GENETIC_IN_VITRO
EP_DNA_STRAND_BREAKS
EP_FPG_SENSITIVE_SITES
HH_GENETIC_IN_VIVO
HH_LUNG_INSTILLATION
EP_RETAINED_FIBRE_BURDEN
EP_RETAINED_FIBRE_HALF_TIME
EP_IN_VIVO_HALF_TIME
EP_CLEARANCE_RATE
EP_LUNG_BURDEN_Tx
HH_CYTOTOXICITY
EP_APOPTOSIS
EP_NECROSIS
EP_CELL_VIABILITY
EP_CELL_PROLIFIRATION
EP_WST_CELL_VIABILITY_ABSORPTION_450_NM
EP_NRU_CELL_VIABILITY_ABSORPTION_540_NM
EP_WST_CELL_VIABILITY_ABSORPTION_420_480_NM
EP_WST_VIABILITY_PERC_OF_CONTROL
EP_NRU_VIABILITY_PERC_OF_CONTROL
EP_LDH_CYTOTOXICITY_PERC_OF_CONTROL
EP_ALAMAR_BLUE_CYTOTOXICITY_PERC_OF_CONTROL
EP_MTS_CYTOTOXICITY_PERC_OF_CONTROL
EP_ALAMAR_BLUE_PERC_DECREASE_AT_MAX_DOSE
EP_RESAZURIN_VIABILITY_PERC_OF_CONTROL
EP_NORMALISED_POST_EXPOSURE_CELL_INDEX_1
EP_IAAC_CYTOTOXICITY_PERC_OF_CONTROL
EP_IAAC_CYTOTOXICITY_ICx
EP_CFE_CYTOTOXICITY_PERC_OF_CONTROL
HH_INFLAMMATION
EP_INFLAMMASOME
EP_IN_VITRO_CYTOKINE_RELEASE
EP_CATHEPSINB_RELEASE
EP_CATHEPSINB_ACTIVITY
EP_IN_VITRO_GRANULOMA_FORMATION
EP_IN_VITRO_GRANULOMA_SIZE
EP_IN_VITRO_GRANULOMA_TIME
EP_IN_VIVO_CELL_COUNT
EP_IN_VIVO_NEUTROPHIL_INFLUX
EP_IN_VIVO_MACROPHAGE_COUNT
EP_IN_VIVO_CYTOKINE_RELEASE
EP_IN_VIVO_INFLAMMATION
EP_LYSOSOMAL_DISRUPTION
HH_FIBROSIS
HH_OXIDATIVE_STRESS
- Description: Oxidative stress is caused by the presence of any of a number of reactive oxygen species (ROS) which the cell is unable to counterbalance. The result is damage to one or more biomolecules including DNA, RNA, proteins and lipids. Oxidative stress has been implicated in the natural aging process as well as a variety of disease states:
ENM_0000037
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#640bbb71-d45e-5d47-a86e-ace7de10544d
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/HH_OXIDATIVE_STRESS
EP_DCFH_RFU_CHANGE
EP_NRF2_LUCIFERASE_ACTIVITY
EP_NRF2_FOLD_LUCIFERASE_ACTIVITY_INDUCTION
EP_DCFH_AIR_LIQUID_INTERFACE_PERC_OF_CONTROL
EP_DCFH_OXIDATIVE_STRESS_PERC_OF_CONTROL
EP_CHANGE_IN_GSH_LEVEL
EP_IN_VITRO_GHS_OXIDATIVE_STRESS_QUANTIFICATION
EP_MDA_LIPID_PEROXIDATION
EP_IN_VITRO_MDA_OXIDATIVE_STRESS_QUANTIFICATION
EP_CARBONYLATION_IOD_NORMALIZED_FOR_UG_PROTEIN
EP_IN_VITRO_HMOX_OXIDATIVE_STRESS_NFOLD_NEG_CONTROL
HH_CELLULAR_INTERNALIZATION
HH_CARCINOGENICITY
HH_REPRODUCTION
HH_DEVELOPMENTAL
HH_NEUROTOXICITY
HH_IMMUNOTOXICITY
EP_LUMINEX_IN_VITRO_CYTOKINE_SECRETION
EP_HEAT_SHOCK_PROTEIN_PERC_OF_CONTROL
HH_BARRIER_INTEGRITY
EP_INVITRO_BARRIER_INTEGRITY
EP_TEER_DECREASE_VERSUS_CONTROL
EP_IN_VITRO_INTESTINAL_MICROBIOTA_INTEGRITY
HH_LUNG_DEPOSITION
EP_DEPOSITION_FRACTION_TRACHEA_BRONCHI
EP_DEPOSITION_FRACTION_ALVEOLI
UE_MANUFACTURE
- Description: OHT 301: Use and exposure information: Manufacture
This stage includes processes by which the registered substance is manufactured from raw materials. Operations which are necessary for the handling of a substance on its own in the manufacturing for export or placing on the EU market are considered to be part of the manufacturing stage (e.g. filling into appropriate containers, storage, addition of stabiliser, dilution to a safer concentration -if necessary for transport safety-). If a substance is directly exported after manufacture, all activities with the substance refer to manufacturing and should be reported under this stage. (Ref: ECHA, Guidance on Information Requirements and Chemical Safety Assessment Chapter R.12: Use description. Version 3.0 2015)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#a3897f72-6c7a-1843-808a-bf31175e61fb
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/UE_MANUFACTURE
UE_FORMULATING_REPACKING
- Description: OHT 302: Use and exposure information: Formulating or re-packing
A use in the formulation stage corresponds to specific activities meant to produce a mixture to be put on the market. This means that during formulation, the substance is transferred and mixed with other substances. It corresponds to activities taking place at industrial sites. Mixing activities during end use are not to be reported under this formulation stage. Manufacturers' or importers' own formulation should be reported under this life cycle stage.
Chemical distributors’ activities such as repacking (which involves transfer of the substance) are to be covered under the formulation stage even if no mixing is carried out. It should be noted that if there is repacking (which is a use), the distributor becomes a downstream user for REACH (with all corresponding duties). This also applies to importers transferring substances from large containers into smaller containers without mixing.
Note that distribution, assembling of small containers for transport or re-labelling activities without transfer of substance are not to be considered as “uses” and have therefore not to be reported. (Ref: ECHA Guidance on Information Requirements and Chemical Safety Assessment Chapter R.12: Use description Version 3.0 - December 2015)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#b53aa5e8-cd7f-3a47-b117-ea2f2e957d7b
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/UE_FORMULATING_REPACKING
UE_USES_AT_INDUSTRIAL_SITES
- Description: OHT 303: Use and exposure information: Uses at industrial sites
All end-uses of the substance (as such or in a mixture) carried out at industrial sites should be reported under this life cycle stage.
A use is an end-use when as its result the substance:
- has reacted (therefore it does not exist anymore in its original form), or
- has become part of an article, or
- has completely been released via waste water or exhaust air, and/or it is contained in waste from this use.
If the substance becomes part of an article, the subsequent life cycle stage (the service life) is to be reported as well.
Manufacturers' or importers' own (end)-uses should be reported under this life cycle stage. (Ref: ECHA Guidance on Information Requirements and Chemical Safety Assessment Chapter R.12: Use description Version 3.0 - December 2015)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#6812e7bf-8f5f-c043-9f49-32c65d91b9c3
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/UE_USES_AT_INDUSTRIAL_SITES
UE_WIDESPREAD_USE_WORKERS
- Description: OHT 304: Use and exposure information: Widespread use by professional workers
Widespread uses by professional workers correspond to uses carried out in the context of commercial activities and assumed to take place in most towns of a certain size, by multiple actors each at low scale e.g. local garage, small cleaning businesses. They are also considered end-uses. The further fate of the substance corresponds to the fate as described for uses at industrial sites.(Ref: ECHA Guidance on Information Requirements and Chemical Safety Assessment Chapter R.12: Use description Version 3.0 - December 2015)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#82e59477-784d-6c4d-aa48-00bd4bb7dddf
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/UE_WIDESPREAD_USE_WORKERS
UE_CONSUMER_USES
- Description: OHT 305: Use and exposure information: Consumer uses
All end-uses of the substance as such or in a mixture carried out by consumers can be reported under this life cycle stage. Uses by consumers are also considered to take place in a widespread manner. (Ref: ECHA Guidance on Information Requirements and Chemical Safety Assessment Chapter R.12: Use description Version 3.0 - December 2015)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#f628445b-9dea-3e40-b00a-b54aa6173f7c
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/UE_CONSUMER_USES
UE_SERVICE_LIFE
- Description: OHT 306: Use and exposure information: Service Life
For a given substance incorporated into an article, the service life is considered to be the period of time an article remains in service (or in use).
Articles containing the substance can be used or processed by consumers, by workers at industrial sites and/or by professional workers. This also includes processing of semi-finished articles by workers with the aim of producing finished articles or repair and maintenance work like for example sanding of surfaces.
When substances remain in dried coatings, adhesives or comparable mixtures after application in/on the article, one or more uses at service life stage should be reported. If the substance is incorporated in buildings, constructions and parts of them, they should be reported in the same way as when they are incorporated into articles.
Substances for sole use as an intermediate should never have any service life described, as by definition they are transformed during industrial use into another substance, which will then potentially be subject to registration obligations.
During the production of an article a registered substance may react and the transformation product may become part of the article. The parent substance is not regarded as an intermediate (as the transformation product is part of an article), and thus the lifecycle of the substance does not end at transformation. It is therefore expected that the use description of the parent covers the service life stage, even though the parent itself is not present in the
article.
In some cases, it might not be easy to determine whether a substance is used as a substance or mixture as such (in which case the use should be documented under the formulation or repacking, industrial, professional or consumer stages) or whether the substance is an integral part of an article. The ECHA Guidance on requirements for substance in articles(https://echa.europa.eu/support/guidance) provides further clarification on the definition of an “article” and decision criteria. (Ref: ECHA Guidance on Information Requirements and Chemical Safety Assessment Chapter R.12: Use description Version 3.0 - December 2015)
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#f2012b1b-5343-8d4f-bc8a-52715068102f
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/UE_SERVICE_LIFE
HE_EXPOSURE_ORAL
HE_EXPOSURE_INHAL
EP_EXPOSURE_CONC_NUMB
EP_EXPOSURE_CONC_MASS
HE_EXPOSURE_DERMAL
DataType
tNUM_Y
tNUM_YT
tNUM_X
tNUM_XT
tNUM_XY
tNUM_XYT
tENUM
tENUM_Y
tENUM_YT
tENUM_X
tENUM_XY
tENUM_XYT
tTEXT
DataOperator
oNONE
oMEAN_XY
oMEAN
oMODE
oMODE_2nd
oMODE_3th
oPEAK
oPEAK_2nd
oPEAK_3th
oMEDIAN
oGEOMEAN
oAUC
oSLOPE
oMIN
oMAX
oNOEC
oLOEC
oLOAEC
oLOAEL
oIC10
oIC50
oEC50
oNORM
DistrQualifier
dqNO
dqPLUS_MIN
dqSD
dqRSD_PERC
dqGEOSD
ControlType
TopCategory
TC_P_CHEM
TC_ENV_FATE
TC_TOX
TC_ECOTOX
ResultSourceType
sEstimated
- Description: Definition: Not based upon any direct measurement.
Estimated = a 'guess' based on expert judgement, which in turn is probably based on a rough form of read-across from another similar-ish chemical or on simplistic modelling. An estimate is only be acceptable as a starting point, e.g. at early stages of Safe-by-Design. A worst-case type default value is probably not really an estimate, but one of those can also be used in a precautionary approach.
- IRI: https://h2020-sbd4nano.github.io/sbd4nano-gracious-owl/gracious.html#499b6e0a-77f8-d546-9295-6678ec312351
- owl:sameAs https://h2020-sbd4nano.github.io/gracious-blueprint/2021/sEstimated
sMeasured
Atom
H
He
Li
Be
B
C
N
O
F
Ne
Na
Mg
Al
Si
P
S
Cl
Ar
K
Ca
Sc
Ti
V
Cr
Mn
Fe
Co
Ni
Cu
Zn
Ga
Ge
As
Se
Br
Kr
Rb
Sr
Y
Zr
Nb
Mo
Tc
Ru
Rh
Pd
Ag
Cd
'In'
Sn
Sb
Te
I
Xe
Cs
Ba
La
Ce
Pr
Nd
Pm
Sm
Eu
Gd
Tb
Dy
Ho
Er
Tm
Yb
Lu
Hf
Ta
W
Re
Os
Ir
Pt
Au
Hg
Tl
Pb
Bi
Po
At
Rn
Fr
Ra
Ac
Th
Pa
U
Np
Pu
Am
Cm
Bk
Cf
Es
Fm
Md
No
Lr
Rf
Db
Sg
Bh
Hs
Mt
Ds
Rg
Cn
Uut
Fl
Uup
Lv
Uus
Uuo
ToxCategory
ObservationScale
atomic
mesoscopic
macroscopic
ParticleSizeLevel
slConstituentParticleLevel
slAgglomerateLevel
DoseDescriptor
ADI
DNEL
OEL
PNEC
EC_x
LC_x
IC_x
TreatmentType
trSample
trNC_untreated
trNC_substance
trNC_NoCells
trPC_substance